Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162152710> ?p ?o ?g. }
- W2162152710 abstract "Recent advances in the molecular characterization of Philadelphia chromosome-negative (Ph-) leukemias and related myeloid disorders have provided a clear rationale for investigating novel targeted therapies. Dasatinib is a tyrosine kinase inhibitor with activity against BCR-ABL, platelet-derived growth factor receptors (PDGFRs), c- KIT, fibroblast growth factor receptors (FGFRs), SRC family kinases (SFKs), and EPHA receptors, all of which have been implicated in the pathogenesis of Ph- leukemias and myeloid disorders. This review presents emerging data on the preclinical and clinical activity of dasatinib in these diseases, which suggest that larger clinical studies are warranted." @default.
- W2162152710 created "2016-06-24" @default.
- W2162152710 creator A5085521139 @default.
- W2162152710 date "2009-05-01" @default.
- W2162152710 modified "2023-09-23" @default.
- W2162152710 title "Preclinical and clinical experience with dasatinib in philadelphia chromosome-negative leukemias and myeloid disorders" @default.
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- W2162152710 doi "https://doi.org/10.1016/j.leukres.2008.10.001" @default.
- W2162152710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4428150" @default.
- W2162152710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19013641" @default.
- W2162152710 hasPublicationYear "2009" @default.
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