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• W2162157751 abstract "ABSTRACT All gammaherpesviruses encode a virion glycoprotein positionally homologous to Epstein-Barr virus gp350. These glycoproteins are thought to be involved in cell binding, but little is known of the roles they might play in the whole viral replication cycle. We have analyzed the contribution of murine gammaherpesvirus 68 (MHV-68) gp150 to viral propagation in vitro and host colonization in vivo. MHV-68 lacking gp150 was viable and showed normal binding to fibroblasts and normal single-cycle lytic replication. Its capacity to infect glycosaminoglycan (GAG)-deficient CHO-K1 cells and NS0 and RAW264.7 cells, which express only low levels of GAGs, was paradoxically increased. However, gp150-deficient MHV-68 spread poorly through fibroblast monolayers, with reduced cell-free infectivity, consistent with a deficit in virus release. Electron microscopy showed gp150-deficient virions clustered on infected-cell plasma membranes. MHV-68-infected cells showed reduced surface GAG expression, suggesting that gp150 prevented virions from rebinding to infected cells after release by making MHV-68 infection GAG dependent. Surprisingly, gp150-deficient viruses showed only a transient lag in lytic replication in vivo and established normal levels of latency. Cell-to-cell virus spread and the proliferation of latently infected cells, for which gp150 was dispensable, therefore appeared to be the major route of virus propagation in an infected host." @default.
• W2162157751 created "2016-06-24" @default.
• W2162157751 creator A5060955442 @default.
• W2162157751 creator A5090169193 @default.
• W2162157751 creator A5027140436 @default.
• W2162157751 date "2004-05-15" @default.
• W2162157751 modified "2023-10-06" @default.
• W2162157751 title "Murine Gammaherpesvirus 68 Lacking gp150 Shows Defective Virion Release but Establishes Normal Latency In Vivo" @default.
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• W2162157751 doi "https://doi.org/10.1128/jvi.78.10.5103-5112.2004" @default.
• W2162157751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/400354" @default.
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