FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162164920> ?p ?o ?g. }

• W2162164920 endingPage "192" @default.
• W2162164920 startingPage "185" @default.
• W2162164920 abstract "Background Heart failure remains a progressive disease with incremental morbidity and mortality despite optimal medical therapy. A growing body of evidence suggests that progressive left ventricular (LV) remodeling is directly related to a deterioration in LV performance and untoward clinical outcomes for heart failure patients. Preclinical and early phase I clinical studies with the CorCap Cardiac Support Device (CSD), a passive cardiac support device that prevents cardiac remodeling, have shown that it is safe and is associated with improvements in LV structure and function, as well as patient symptomatology. Methods and results The Acorn Pivotal Trial is a pivotal prospective, randomized, evaluation of the CorCap CSD in patients with New York Heart Association class III-IV heart failure. Patients will be enrolled into one of two different strata. Patients who require a mitral valve repair/replacement (MVR) will fall into the “MVR stratum” and will be randomized to either treatment (MVR surgery plus the CSD) or control (MVR surgery alone). Patients who do not have a clinical indication for MVR surgery will fall into the “no-MVR stratum” and will also be randomized to either treatment (CSD implant plus optimal medical therapy) or control (optimal medical therapy alone). A total of 300 patients (150 treatment and 150 control) will be enrolled. The primary endpoint of the trial is the change in clinical status from baseline to the end of the efficacy phase (1 year), as determined by a clinical composite score. Patients will be classified as improved, worsened, or unchanged based upon patient vital status, the occurrence of a major cardiac procedure indicative of heart failure progression, and a change in the assessment of New York Heart Association functional class. Conclusions The Acorn Pivotal Trial will formally test the hypothesis that preventing LV remodeling using a passive cardiac support device will favorably impact the untoward natural history of heart failure and thus represents an important departure from all previous medical and device studies that have been reported to date." @default.
• W2162164920 created "2016-06-24" @default.
• W2162164920 creator A5039589228 @default.
• W2162164920 creator A5042167997 @default.
• W2162164920 creator A5054605170 @default.
• W2162164920 creator A5076497318 @default.
• W2162164920 creator A5076697833 @default.
• W2162164920 creator A5091291156 @default.
• W2162164920 date "2004-06-01" @default.
• W2162164920 modified "2023-10-14" @default.
• W2162164920 title "Rationale, design, and methods for a pivotal randomized clinical trial for the assessment of a cardiac support device in patients with New York health association class III-IV heart failure" @default.
• W2162164920 cites W1971705632 @default.
• W2162164920 cites W1989353963 @default.
• W2162164920 cites W1989767298 @default.
• W2162164920 cites W1990459277 @default.
• W2162164920 cites W1997780004 @default.
• W2162164920 cites W2003870048 @default.
• W2162164920 cites W2013160285 @default.
• W2162164920 cites W2014258463 @default.
• W2162164920 cites W2024175660 @default.
• W2162164920 cites W2029129384 @default.
• W2162164920 cites W2032156560 @default.
• W2162164920 cites W2046383587 @default.
• W2162164920 cites W2047907380 @default.
• W2162164920 cites W2050839858 @default.
• W2162164920 cites W2056893352 @default.
• W2162164920 cites W2058580807 @default.
• W2162164920 cites W2065833580 @default.
• W2162164920 cites W2087353291 @default.
• W2162164920 cites W2123495845 @default.
• W2162164920 cites W2134463370 @default.
• W2162164920 cites W2141772881 @default.
• W2162164920 cites W2150506596 @default.
• W2162164920 cites W2152094259 @default.
• W2162164920 cites W2159812023 @default.
• W2162164920 cites W2326508838 @default.
• W2162164920 cites W2335083084 @default.
• W2162164920 cites W2469805673 @default.
• W2162164920 cites W2585382523 @default.
• W2162164920 cites W3144470180 @default.
• W2162164920 cites W4238077615 @default.
• W2162164920 cites W4361868645 @default.
• W2162164920 doi "https://doi.org/10.1016/j.cardfail.2003.10.007" @default.
• W2162164920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15190527" @default.
• W2162164920 hasPublicationYear "2004" @default.
• W2162164920 type Work @default.
• W2162164920 sameAs 2162164920 @default.
• W2162164920 citedByCount "57" @default.
• W2162164920 countsByYear W21621649202012 @default.
• W2162164920 countsByYear W21621649202013 @default.
• W2162164920 countsByYear W21621649202014 @default.
• W2162164920 countsByYear W21621649202017 @default.
• W2162164920 countsByYear W21621649202018 @default.
• W2162164920 countsByYear W21621649202019 @default.
• W2162164920 crossrefType "journal-article" @default.
• W2162164920 hasAuthorship W2162164920A5039589228 @default.
• W2162164920 hasAuthorship W2162164920A5042167997 @default.
• W2162164920 hasAuthorship W2162164920A5054605170 @default.
• W2162164920 hasAuthorship W2162164920A5076497318 @default.
• W2162164920 hasAuthorship W2162164920A5076697833 @default.
• W2162164920 hasAuthorship W2162164920A5091291156 @default.
• W2162164920 hasConcept C126322002 @default.
• W2162164920 hasConcept C141071460 @default.
• W2162164920 hasConcept C164705383 @default.
• W2162164920 hasConcept C168563851 @default.
• W2162164920 hasConcept C203092338 @default.
• W2162164920 hasConcept C2778198053 @default.
• W2162164920 hasConcept C535046627 @default.
• W2162164920 hasConcept C71924100 @default.
• W2162164920 hasConceptScore W2162164920C126322002 @default.
• W2162164920 hasConceptScore W2162164920C141071460 @default.
• W2162164920 hasConceptScore W2162164920C164705383 @default.
• W2162164920 hasConceptScore W2162164920C168563851 @default.
• W2162164920 hasConceptScore W2162164920C203092338 @default.
• W2162164920 hasConceptScore W2162164920C2778198053 @default.
• W2162164920 hasConceptScore W2162164920C535046627 @default.
• W2162164920 hasConceptScore W2162164920C71924100 @default.
• W2162164920 hasIssue "3" @default.
• W2162164920 hasLocation W21621649201 @default.
• W2162164920 hasLocation W21621649202 @default.
• W2162164920 hasOpenAccess W2162164920 @default.
• W2162164920 hasPrimaryLocation W21621649201 @default.
• W2162164920 hasRelatedWork W1531601525 @default.
• W2162164920 hasRelatedWork W2758277628 @default.
• W2162164920 hasRelatedWork W2935909890 @default.
• W2162164920 hasRelatedWork W2948807893 @default.
• W2162164920 hasRelatedWork W3173606202 @default.
• W2162164920 hasRelatedWork W3183948672 @default.
• W2162164920 hasRelatedWork W4387497383 @default.
• W2162164920 hasRelatedWork W588655279 @default.
• W2162164920 hasRelatedWork W2778153218 @default.
• W2162164920 hasRelatedWork W3110381201 @default.
• W2162164920 hasVolume "10" @default.
• W2162164920 isParatext "false" @default.
• W2162164920 isRetracted "false" @default.
• W2162164920 magId "2162164920" @default.
• W2162164920 workType "article" @default.