FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162176883> ?p ?o ?g. }

• W2162176883 endingPage "702" @default.
• W2162176883 startingPage "696" @default.
• W2162176883 abstract "Global DNA hypomethylation is associated with increased chromosomal instability and plays an important role in tumorigenesis. The methylation status of the long interspersed nuclear element-1 (LINE-1) element is a useful surrogate marker for global DNA methylation. Although LINE-1 hypomethylation is recognized as a poor prognostic marker, the correlation of LINE-1 methylation level with tumor suppressor gene mutation, chromosomal instability, and clinical significance in esophageal squamous cell carcinoma (ESCC) remains unclear. Using resected tumor tissues and the corresponding normal esophageal mucosa from 105 patients with ESCC, bisulfite pyrosequencing analysis was performed to quantify the LINE-1 methylation levels. p53 mutations in exons two to ten were detected by polymerase chain reaction direct sequencing. Chromosomal instability was assessed by single nucleotide polymorphism array comparative genomic hybridization analysis. The LINE-1 methylation level of ESCC was significantly lower than matched normal mucosa. LINE-1 methylation levels of normal mucosa from the esophagus had a significant inverse correlation with both cigarette smoking and alcohol consumption of the study subjects. LINE-1 hypomethylation of ESCC was significantly associated with lymph node metastasis, lymphovascular invasion, the frequency of p53 mutation and poor survivability. The LINE-1 methylation levels in ESCC had a significant inverse association with the percentage of copy number alterations in the whole genome, mirroring chromosomal instability. Our results suggested that whole genome hypomethylation caused by chronic inflammation could initiate carcinogenesis of esophageal squamous cells through chromosomal instability. In addition, chromosomal instability associated with the global hypomethylation might correlate highly with the progression of ESCC." @default.
• W2162176883 created "2016-06-24" @default.
• W2162176883 creator A5001212039 @default.
• W2162176883 creator A5004420462 @default.
• W2162176883 creator A5018750173 @default.
• W2162176883 creator A5021000463 @default.
• W2162176883 creator A5025959729 @default.
• W2162176883 creator A5026111775 @default.
• W2162176883 creator A5037598716 @default.
• W2162176883 creator A5042141137 @default.
• W2162176883 creator A5046758275 @default.
• W2162176883 creator A5063723368 @default.
• W2162176883 creator A5072378382 @default.
• W2162176883 creator A5091180256 @default.
• W2162176883 date "2014-06-05" @default.
• W2162176883 modified "2023-10-02" @default.
• W2162176883 title "Chromosomal Instability Associated with Global DNA Hypomethylation is Associated with the Initiation and Progression of Esophageal Squamous Cell Carcinoma" @default.
• W2162176883 cites W1601008877 @default.
• W2162176883 cites W1650797637 @default.
• W2162176883 cites W1964060034 @default.
• W2162176883 cites W1966163762 @default.
• W2162176883 cites W1969704595 @default.
• W2162176883 cites W1975786537 @default.
• W2162176883 cites W1981499089 @default.
• W2162176883 cites W1985267763 @default.
• W2162176883 cites W1987561568 @default.
• W2162176883 cites W1990381590 @default.
• W2162176883 cites W1992220669 @default.
• W2162176883 cites W1999665897 @default.
• W2162176883 cites W2006992975 @default.
• W2162176883 cites W2020986263 @default.
• W2162176883 cites W2024819383 @default.
• W2162176883 cites W2027229185 @default.
• W2162176883 cites W2029060209 @default.
• W2162176883 cites W2031385304 @default.
• W2162176883 cites W2034531741 @default.
• W2162176883 cites W2041013779 @default.
• W2162176883 cites W2041955966 @default.
• W2162176883 cites W2051541780 @default.
• W2162176883 cites W2070674141 @default.
• W2162176883 cites W2079852484 @default.
• W2162176883 cites W2082353425 @default.
• W2162176883 cites W2083467502 @default.
• W2162176883 cites W2084831115 @default.
• W2162176883 cites W2090494026 @default.
• W2162176883 cites W2096717046 @default.
• W2162176883 cites W2098739456 @default.
• W2162176883 cites W2102191231 @default.
• W2162176883 cites W2106401558 @default.
• W2162176883 cites W2115945903 @default.
• W2162176883 cites W2120760498 @default.
• W2162176883 cites W2128961154 @default.
• W2162176883 cites W2134709564 @default.
• W2162176883 cites W2142970835 @default.
• W2162176883 cites W2143706694 @default.
• W2162176883 cites W2150170782 @default.
• W2162176883 cites W2150269898 @default.
• W2162176883 cites W2155104309 @default.
• W2162176883 cites W2160289121 @default.
• W2162176883 cites W4252560545 @default.
• W2162176883 doi "https://doi.org/10.1245/s10434-014-3818-z" @default.
• W2162176883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24898425" @default.
• W2162176883 hasPublicationYear "2014" @default.
• W2162176883 type Work @default.
• W2162176883 sameAs 2162176883 @default.
• W2162176883 citedByCount "47" @default.
• W2162176883 countsByYear W21621768832015 @default.
• W2162176883 countsByYear W21621768832016 @default.
• W2162176883 countsByYear W21621768832017 @default.
• W2162176883 countsByYear W21621768832018 @default.
• W2162176883 countsByYear W21621768832019 @default.
• W2162176883 countsByYear W21621768832020 @default.
• W2162176883 countsByYear W21621768832021 @default.
• W2162176883 countsByYear W21621768832022 @default.
• W2162176883 countsByYear W21621768832023 @default.
• W2162176883 crossrefType "journal-article" @default.
• W2162176883 hasAuthorship W2162176883A5001212039 @default.
• W2162176883 hasAuthorship W2162176883A5004420462 @default.
• W2162176883 hasAuthorship W2162176883A5018750173 @default.
• W2162176883 hasAuthorship W2162176883A5021000463 @default.
• W2162176883 hasAuthorship W2162176883A5025959729 @default.
• W2162176883 hasAuthorship W2162176883A5026111775 @default.
• W2162176883 hasAuthorship W2162176883A5037598716 @default.
• W2162176883 hasAuthorship W2162176883A5042141137 @default.
• W2162176883 hasAuthorship W2162176883A5046758275 @default.
• W2162176883 hasAuthorship W2162176883A5063723368 @default.
• W2162176883 hasAuthorship W2162176883A5072378382 @default.
• W2162176883 hasAuthorship W2162176883A5091180256 @default.
• W2162176883 hasBestOaLocation W21621768832 @default.
• W2162176883 hasConcept C104317684 @default.
• W2162176883 hasConcept C121608353 @default.
• W2162176883 hasConcept C140752955 @default.
• W2162176883 hasConcept C142724271 @default.
• W2162176883 hasConcept C143425029 @default.
• W2162176883 hasConcept C150194340 @default.
• W2162176883 hasConcept C153911025 @default.
• W2162176883 hasConcept C178169997 @default.
• W2162176883 hasConcept C180754005 @default.

• next