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- W2162178768 abstract "The role of G protein-mediated signal transduction in the production of endolymph, an extracellular fluid of unusual ionic composition, is beginning to be understood. The identity of Galpha subunits in the stria vascularis and the spiral ligament of the lateral wall of the cochlear duct is well established. However, little is known about the presence of betagamma subunits. This study used immunohistochemistry to investigate the distribution of G protein betagamma subunits in the lateral wall of the cochlea. Temporal bones of 6- to 8-week-old rats were fixed in 4% paraformaldehyde and 0.1% glutaraldehyde and processed for embedding in paraffin wax. The dewaxed, midmodiolar sections of the cochlea were incubated with subunit-specific polyclonal antibodies. The results show that the pattern of immunoreactivity varies for the G protein beta1-4 and gamma1-3, 5 and 7 subunits in the stria vascularis and spiral ligament. In the stria vascularis, immunoreactivity was detected for beta2, beta3, beta4, gamma1, gamma2 and gamma7 subunits. All five types of fibrocytes in the spiral ligament exhibited positive staining for gamma2 and gamma7. However, immunoreactivity for beta1-4 subunits was variable. Immunoreactivity for gamma3 and gamma5 subunits was not detected in the lateral cochlear wall. The expression pattern of G protein betagamma subunits in lateral wall provides a basis for interpreting the functions of G protein-coupled receptors in cochlear fluid homeostasis." @default.
- W2162178768 created "2016-06-24" @default.
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- W2162178768 creator A5043593209 @default.
- W2162178768 date "2006-02-01" @default.
- W2162178768 modified "2023-10-16" @default.
- W2162178768 title "Immunohistochemical localization of G protein betagamma subunits in the lateral wall of the rat cochlea" @default.
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- W2162178768 doi "https://doi.org/10.1111/j.1469-7580.2006.00526.x" @default.
- W2162178768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2100195" @default.
- W2162178768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16441565" @default.
- W2162178768 hasPublicationYear "2006" @default.
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