Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162199203> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2162199203 endingPage "667" @default.
- W2162199203 startingPage "668" @default.
- W2162199203 abstract "Although the efficiency of retrovirus-mediated gene delivery can be enhanced by several physicochemical approaches reported (e.g., addition of polycations and spinoculation), systematic analysis of retroviral transduction combined with experimental data remains to be challenged. With the aid of a reasonable mathematical description of an experimental system, we can therefore predict and optimize the retroviral gene delivery on a quantitative basis of understanding. In this study, we formulated a mathematical model involved with diffusion, decay and uptake of retroviral vectors onto the target cells resided on a solid culture surface. The model was solved analytically by the Laplace transform method. The analytical solutions were then fitted with experimental data to compute two unknown parameters: concentration of infectious retrovirus and transduction rate constant. Our results showed that the concentration of infectious retrovirus determined by the titration method was approximately hundred-fold lower than the one calculated by fitting experimental data with the mathematical solutions. More importantly, effects of polycation (i.e., Polybrene) on ex vivo retroviral transduction were illustrated in a quantitative way by estimating the transduction rate constant, which represents a more reliable parameter to determine the degree of transduction of a retroviral vector to a given target cell." @default.
- W2162199203 created "2016-06-24" @default.
- W2162199203 creator A5028823583 @default.
- W2162199203 creator A5049528038 @default.
- W2162199203 date "2002-01-22" @default.
- W2162199203 modified "2023-09-25" @default.
- W2162199203 title "Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery" @default.
- W2162199203 cites W1483350920 @default.
- W2162199203 cites W1539947129 @default.
- W2162199203 cites W1560014347 @default.
- W2162199203 cites W1732481302 @default.
- W2162199203 cites W1788853185 @default.
- W2162199203 cites W1965094062 @default.
- W2162199203 cites W1967229218 @default.
- W2162199203 cites W1983980421 @default.
- W2162199203 cites W1992156880 @default.
- W2162199203 cites W1997408589 @default.
- W2162199203 cites W1997582694 @default.
- W2162199203 cites W2003750964 @default.
- W2162199203 cites W2006351633 @default.
- W2162199203 cites W2009751140 @default.
- W2162199203 cites W2014469005 @default.
- W2162199203 cites W2016792838 @default.
- W2162199203 cites W2030765885 @default.
- W2162199203 cites W2066027429 @default.
- W2162199203 cites W2067229421 @default.
- W2162199203 cites W2068286575 @default.
- W2162199203 cites W2080088598 @default.
- W2162199203 cites W2089894429 @default.
- W2162199203 cites W2095314092 @default.
- W2162199203 cites W2098264302 @default.
- W2162199203 cites W2105007068 @default.
- W2162199203 cites W2122799356 @default.
- W2162199203 cites W2136381210 @default.
- W2162199203 cites W2148660248 @default.
- W2162199203 cites W2151919704 @default.
- W2162199203 cites W2165116671 @default.
- W2162199203 doi "https://doi.org/10.1002/bit.10214" @default.
- W2162199203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11807762" @default.
- W2162199203 hasPublicationYear "2002" @default.
- W2162199203 type Work @default.
- W2162199203 sameAs 2162199203 @default.
- W2162199203 citedByCount "14" @default.
- W2162199203 crossrefType "journal-article" @default.
- W2162199203 hasAuthorship W2162199203A5028823583 @default.
- W2162199203 hasAuthorship W2162199203A5049528038 @default.
- W2162199203 hasConcept C104317684 @default.
- W2162199203 hasConcept C111599444 @default.
- W2162199203 hasConcept C12554922 @default.
- W2162199203 hasConcept C135983454 @default.
- W2162199203 hasConcept C15152581 @default.
- W2162199203 hasConcept C186060115 @default.
- W2162199203 hasConcept C2778431562 @default.
- W2162199203 hasConcept C54355233 @default.
- W2162199203 hasConcept C70721500 @default.
- W2162199203 hasConcept C86803240 @default.
- W2162199203 hasConceptScore W2162199203C104317684 @default.
- W2162199203 hasConceptScore W2162199203C111599444 @default.
- W2162199203 hasConceptScore W2162199203C12554922 @default.
- W2162199203 hasConceptScore W2162199203C135983454 @default.
- W2162199203 hasConceptScore W2162199203C15152581 @default.
- W2162199203 hasConceptScore W2162199203C186060115 @default.
- W2162199203 hasConceptScore W2162199203C2778431562 @default.
- W2162199203 hasConceptScore W2162199203C54355233 @default.
- W2162199203 hasConceptScore W2162199203C70721500 @default.
- W2162199203 hasConceptScore W2162199203C86803240 @default.
- W2162199203 hasIssue "6" @default.
- W2162199203 hasLocation W21621992031 @default.
- W2162199203 hasLocation W21621992032 @default.
- W2162199203 hasOpenAccess W2162199203 @default.
- W2162199203 hasPrimaryLocation W21621992031 @default.
- W2162199203 hasRelatedWork W2019967477 @default.
- W2162199203 hasRelatedWork W2035923453 @default.
- W2162199203 hasRelatedWork W2048291054 @default.
- W2162199203 hasRelatedWork W2056020011 @default.
- W2162199203 hasRelatedWork W2098072068 @default.
- W2162199203 hasRelatedWork W2412262745 @default.
- W2162199203 hasRelatedWork W2755244558 @default.
- W2162199203 hasRelatedWork W41186432 @default.
- W2162199203 hasRelatedWork W4308907425 @default.
- W2162199203 hasRelatedWork W933855198 @default.
- W2162199203 hasVolume "77" @default.
- W2162199203 isParatext "false" @default.
- W2162199203 isRetracted "false" @default.
- W2162199203 magId "2162199203" @default.
- W2162199203 workType "article" @default.