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- W2162208045 abstract "To Editor.— In his article titled Prazosin and Clonidine for Moderately Severe Hypertension, Walter M. Kirkendall, MD (240:2553, 1978), describes cholesterol-raising effect of diuretics chlorthalidone and polythiazide, citing also reports of Ames and Hill 1 and of Schnaper et al. 2 Although noting that former observed this effect for hydrochlorothiazide also, Dr Kirkendall asserts that the effect of thiazide diuretics is not as well established, apparently based on failure of data from Framingham Heart Study 3 to show such an association. Two observations are relevant to this question: The first is that it is not surprising for there to be failure to recognize such an effect (5% to 10% change) in an uncontrolled community study not designed to be sensitive to such questions. Uncontrollable variation in drug use (both dosage and duration) as well as nonrandom dietary intervention could easily obscure such aneffect." @default.
- W2162208045 created "2016-06-24" @default.
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- W2162208045 date "1979-10-12" @default.
- W2162208045 modified "2023-10-18" @default.
- W2162208045 title "Diuretics and Cholesterol Elevation" @default.
- W2162208045 cites W2000908650 @default.
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- W2162208045 doi "https://doi.org/10.1001/jama.1979.03300150018013" @default.
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