FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162214744> ?p ?o ?g. }

• W2162214744 endingPage "600" @default.
• W2162214744 startingPage "594" @default.
• W2162214744 abstract "Iron metabolism is of crucial importance in the biology and pathophysiology of the lower respiratory tract. As with many other factors involved in inflammation, it is very important that an appropriate iron balance is maintained. Local deficiency could impair growth and proliferation of cells responsible for the inflammatory response and tissue repair (lymphocytes and fibroblasts) and the synthesis of mediators (for example, arachidonic acid derivatives).1 In contrast, excessive accumulation of iron, especially in free form—that is, not bound to one of the specific iron-binding proteins—facilitates the generation of potentially toxic hydroxyl radicals2 and increases the ability of intracellular bacteria such as mycobacteria to grow.3-5 Research into iron metabolism in the lower respiratory tract has taken advantage of bronchoalveolar lavage, a technique by which it is possible to obtain the cells and fluid lining the alveoli. Determination of iron content in the alveolo-interstitial region shows that 80% is present in the cells and 20% in the epithelial lining fluid of the lung.6 Since alveolar macrophages constitute the major cell population in this region, and because the iron content of lymphocytes, neutrophils, and monocytes is very low in comparison with alveolar macrophages,6 7 these cells are of special interest.In this paper we review current knowledge of iron and iron-binding proteins in bronchoalveolar lavage fluid, and the special features of iron metabolism in alveolar macrophages.Iron is principally required for haemoglobin synthesis, and its uptake, utilisation and storage are carefully regulated to ensure an adequate supply without excessive accumulation which could lead to toxicity. Intestinal iron absorption is related to erythropoietic requirements, although the regulatory mechanism(s) remain unknown. The usual source of iron in the lung is serum iron which is derived from catabolised erythrocytes and absorbed iron. However, in pathological states, iron can enter the lung …" @default.
• W2162214744 created "2016-06-24" @default.
• W2162214744 creator A5018216805 @default.
• W2162214744 creator A5063667668 @default.
• W2162214744 creator A5073281731 @default.
• W2162214744 date "1998-07-01" @default.
• W2162214744 modified "2023-10-18" @default.
• W2162214744 title "Iron metabolism in the lower respiratory tract" @default.
• W2162214744 cites W101110666 @default.
• W2162214744 cites W1499834471 @default.
• W2162214744 cites W1561905104 @default.
• W2162214744 cites W1671669579 @default.
• W2162214744 cites W1830935255 @default.
• W2162214744 cites W1923166281 @default.
• W2162214744 cites W1960038440 @default.
• W2162214744 cites W1963495813 @default.
• W2162214744 cites W1965986754 @default.
• W2162214744 cites W1977032555 @default.
• W2162214744 cites W1982842460 @default.
• W2162214744 cites W1987586330 @default.
• W2162214744 cites W1996188407 @default.
• W2162214744 cites W1999869370 @default.
• W2162214744 cites W2002931735 @default.
• W2162214744 cites W2008747794 @default.
• W2162214744 cites W2010255537 @default.
• W2162214744 cites W2020247480 @default.
• W2162214744 cites W2025354563 @default.
• W2162214744 cites W2025457574 @default.
• W2162214744 cites W2026961039 @default.
• W2162214744 cites W2030155787 @default.
• W2162214744 cites W2030464612 @default.
• W2162214744 cites W2030584890 @default.
• W2162214744 cites W203060707 @default.
• W2162214744 cites W2037652311 @default.
• W2162214744 cites W2044953143 @default.
• W2162214744 cites W2052567913 @default.
• W2162214744 cites W2056905100 @default.
• W2162214744 cites W2065861817 @default.
• W2162214744 cites W2073617374 @default.
• W2162214744 cites W2076374669 @default.
• W2162214744 cites W2079679475 @default.
• W2162214744 cites W2091630752 @default.
• W2162214744 cites W2094900869 @default.
• W2162214744 cites W2103165503 @default.
• W2162214744 cites W2108196265 @default.
• W2162214744 cites W2113710155 @default.
• W2162214744 cites W2116266889 @default.
• W2162214744 cites W2116347119 @default.
• W2162214744 cites W2124595022 @default.
• W2162214744 cites W2128491519 @default.
• W2162214744 cites W2135899618 @default.
• W2162214744 cites W2139904605 @default.
• W2162214744 cites W2140127725 @default.
• W2162214744 cites W2145327594 @default.
• W2162214744 cites W2166257949 @default.
• W2162214744 cites W2203832571 @default.
• W2162214744 cites W2232769633 @default.
• W2162214744 cites W2258696481 @default.
• W2162214744 cites W2316494210 @default.
• W2162214744 cites W2328685779 @default.
• W2162214744 cites W2395824863 @default.
• W2162214744 cites W2402235760 @default.
• W2162214744 cites W2404590122 @default.
• W2162214744 cites W2412338600 @default.
• W2162214744 cites W2412352333 @default.
• W2162214744 cites W2414158350 @default.
• W2162214744 cites W2415328685 @default.
• W2162214744 cites W2417011670 @default.
• W2162214744 cites W2419503374 @default.
• W2162214744 cites W2465064176 @default.
• W2162214744 cites W2781279492 @default.
• W2162214744 doi "https://doi.org/10.1136/thx.53.7.594" @default.
• W2162214744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1745270" @default.
• W2162214744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9797761" @default.
• W2162214744 hasPublicationYear "1998" @default.
• W2162214744 type Work @default.
• W2162214744 sameAs 2162214744 @default.
• W2162214744 citedByCount "152" @default.
• W2162214744 countsByYear W21622147442012 @default.
• W2162214744 countsByYear W21622147442013 @default.
• W2162214744 countsByYear W21622147442014 @default.
• W2162214744 countsByYear W21622147442015 @default.
• W2162214744 countsByYear W21622147442016 @default.
• W2162214744 countsByYear W21622147442017 @default.
• W2162214744 countsByYear W21622147442018 @default.
• W2162214744 countsByYear W21622147442019 @default.
• W2162214744 countsByYear W21622147442020 @default.
• W2162214744 countsByYear W21622147442021 @default.
• W2162214744 countsByYear W21622147442022 @default.
• W2162214744 countsByYear W21622147442023 @default.
• W2162214744 crossrefType "journal-article" @default.
• W2162214744 hasAuthorship W2162214744A5018216805 @default.
• W2162214744 hasAuthorship W2162214744A5063667668 @default.
• W2162214744 hasAuthorship W2162214744A5073281731 @default.
• W2162214744 hasBestOaLocation W21622147441 @default.
• W2162214744 hasConcept C126322002 @default.
• W2162214744 hasConcept C177713679 @default.
• W2162214744 hasConcept C2776012195 @default.

• next