Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162215794> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2162215794 abstract "Increased apoptosis of myeloid precursors appears to contribute to the pathophysiology of cytopenias in myelodysplastic syndromes (MDS). Fas /APO-1(CD95) is a cell surface protein inducing an apoptotic signal after its binding to Fas ligand or to a functional anti-Fas antibody. Here we studied Fas expression by immunocytochemistry on marrow slides from 30 cases of MDS. Increased Fas expression in erythroblasts and/or immature granulocytes, compared to controls, was seen in 12 (40%) of the cases. In addition, in 16 of the 18 cases with > or = 5% marrow blasts, a variable proportion of blasts expressed Fas. Increased apoptosis was found by morphological analysis and/or TUNEL technique in marrow cells from 8 of the 26 cases analyzed (31%) The ability of Fas antigen to trigger apoptosis was studied after addition of a functional anti Fas antibody in 5 of the patients with Fas overexpression. Addition of this antibody, however, only lead to mild increase of apoptosis in immature granulocytes (but not other myeloid cells) in 2 of the 5 cases. Thus, increased Fas expression is seen in myeloid and/or blast cells in the majority of MDS cases. However, the relationship between this finding and increased apoptosis in MDS still remains to be established." @default.
- W2162215794 created "2016-06-24" @default.
- W2162215794 creator A5014838075 @default.
- W2162215794 creator A5033797515 @default.
- W2162215794 creator A5051478372 @default.
- W2162215794 creator A5053669551 @default.
- W2162215794 creator A5057273166 @default.
- W2162215794 creator A5059980892 @default.
- W2162215794 date "1998-01-01" @default.
- W2162215794 modified "2023-09-27" @default.
- W2162215794 title "Fas/APO-1 (CD95) Expression in Myelodysplastic Syndromes" @default.
- W2162215794 cites W1836932878 @default.
- W2162215794 cites W2002062621 @default.
- W2162215794 cites W2041466047 @default.
- W2162215794 cites W2065628698 @default.
- W2162215794 cites W2075809552 @default.
- W2162215794 cites W2278431283 @default.
- W2162215794 cites W2296225964 @default.
- W2162215794 cites W2463933323 @default.
- W2162215794 cites W2979732728 @default.
- W2162215794 cites W4253916874 @default.
- W2162215794 doi "https://doi.org/10.3109/10428199809057543" @default.
- W2162215794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9713962" @default.
- W2162215794 hasPublicationYear "1998" @default.
- W2162215794 type Work @default.
- W2162215794 sameAs 2162215794 @default.
- W2162215794 citedByCount "33" @default.
- W2162215794 countsByYear W21622157942012 @default.
- W2162215794 countsByYear W21622157942014 @default.
- W2162215794 crossrefType "journal-article" @default.
- W2162215794 hasAuthorship W2162215794A5014838075 @default.
- W2162215794 hasAuthorship W2162215794A5033797515 @default.
- W2162215794 hasAuthorship W2162215794A5051478372 @default.
- W2162215794 hasAuthorship W2162215794A5053669551 @default.
- W2162215794 hasAuthorship W2162215794A5057273166 @default.
- W2162215794 hasAuthorship W2162215794A5059980892 @default.
- W2162215794 hasConcept C134018914 @default.
- W2162215794 hasConcept C147483822 @default.
- W2162215794 hasConcept C159654299 @default.
- W2162215794 hasConcept C190283241 @default.
- W2162215794 hasConcept C196795494 @default.
- W2162215794 hasConcept C203014093 @default.
- W2162215794 hasConcept C2778461978 @default.
- W2162215794 hasConcept C2778729363 @default.
- W2162215794 hasConcept C2779282312 @default.
- W2162215794 hasConcept C2780007613 @default.
- W2162215794 hasConcept C2780817109 @default.
- W2162215794 hasConcept C3031857 @default.
- W2162215794 hasConcept C31573885 @default.
- W2162215794 hasConcept C35866371 @default.
- W2162215794 hasConcept C502942594 @default.
- W2162215794 hasConcept C55493867 @default.
- W2162215794 hasConcept C66008609 @default.
- W2162215794 hasConcept C86803240 @default.
- W2162215794 hasConceptScore W2162215794C134018914 @default.
- W2162215794 hasConceptScore W2162215794C147483822 @default.
- W2162215794 hasConceptScore W2162215794C159654299 @default.
- W2162215794 hasConceptScore W2162215794C190283241 @default.
- W2162215794 hasConceptScore W2162215794C196795494 @default.
- W2162215794 hasConceptScore W2162215794C203014093 @default.
- W2162215794 hasConceptScore W2162215794C2778461978 @default.
- W2162215794 hasConceptScore W2162215794C2778729363 @default.
- W2162215794 hasConceptScore W2162215794C2779282312 @default.
- W2162215794 hasConceptScore W2162215794C2780007613 @default.
- W2162215794 hasConceptScore W2162215794C2780817109 @default.
- W2162215794 hasConceptScore W2162215794C3031857 @default.
- W2162215794 hasConceptScore W2162215794C31573885 @default.
- W2162215794 hasConceptScore W2162215794C35866371 @default.
- W2162215794 hasConceptScore W2162215794C502942594 @default.
- W2162215794 hasConceptScore W2162215794C55493867 @default.
- W2162215794 hasConceptScore W2162215794C66008609 @default.
- W2162215794 hasConceptScore W2162215794C86803240 @default.
- W2162215794 hasLocation W21622157941 @default.
- W2162215794 hasLocation W21622157942 @default.
- W2162215794 hasOpenAccess W2162215794 @default.
- W2162215794 hasPrimaryLocation W21622157941 @default.
- W2162215794 hasRelatedWork W2026898144 @default.
- W2162215794 hasRelatedWork W2027274431 @default.
- W2162215794 hasRelatedWork W2048893796 @default.
- W2162215794 hasRelatedWork W2162215794 @default.
- W2162215794 hasRelatedWork W23310454 @default.
- W2162215794 hasRelatedWork W2369251668 @default.
- W2162215794 hasRelatedWork W2411752201 @default.
- W2162215794 hasRelatedWork W2518700183 @default.
- W2162215794 hasRelatedWork W2551466832 @default.
- W2162215794 hasRelatedWork W42711520 @default.
- W2162215794 isParatext "false" @default.
- W2162215794 isRetracted "false" @default.
- W2162215794 magId "2162215794" @default.
- W2162215794 workType "article" @default.