FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162223306> ?p ?o ?g. }

• W2162223306 endingPage "78" @default.
• W2162223306 startingPage "363" @default.
• W2162223306 abstract "Positive identification of osteoclast percursors has not yet been possible. The authors have, in the present report, used a model system in the rat in which it is possible to induce the formation of multinucleated osteoclasts at a predictable and reproducible site and time (Tran Van P, Vignery A, Baron R. Anat Rec 1982, 202:445-451; Cell Tissue Res 1982, 225:283-292). This system allowed the investigation of the cellular events occurring locally during the recruitment and differentiation of osteoclast precursors. Prior to the formation of multinucleated osteoclasts, mononuclear cells positive for fluoride-inhibitable nonspecific esterase and cells positive for tartrate-resistant acid phosphatase increase in number locally. Double staining procedures demonstrated the presence of both enzymes in a number of cells, thereby suggesting that they are steps in the differentiation of a single cell population. Ultrastructural studies show that lysosomal enzymes are present in every compartment of the biosynthetic pathway, in small primary lysosomes and various forms of storage granules. As these precursors arrive at the bone surface, the storage granule lysosomes are markedly depleted. It is concluded that mononuclear precursors of the osteoclast are members of the mononuclear-phagocyte lineage and differentiate early to synthesize, store, and later secrete large quantities of lysosomal enzymes. The mature osteoclast, which, as its precursor, is positive for the mononuclear-phagocyte marker enzyme nonspecific esterase, results from the fusion of these mononuclear precursors, which occurs only after their attachment to the bone surface to be resorbed." @default.
• W2162223306 created "2016-06-24" @default.
• W2162223306 creator A5011357491 @default.
• W2162223306 creator A5018898924 @default.
• W2162223306 creator A5028238095 @default.
• W2162223306 creator A5032350824 @default.
• W2162223306 creator A5053072500 @default.
• W2162223306 date "1986-02-01" @default.
• W2162223306 modified "2023-09-27" @default.
• W2162223306 title "Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts." @default.
• W2162223306 cites W1484545760 @default.
• W2162223306 cites W1680224209 @default.
• W2162223306 cites W19109719 @default.
• W2162223306 cites W1964799645 @default.
• W2162223306 cites W1970742097 @default.
• W2162223306 cites W1971420206 @default.
• W2162223306 cites W1978234566 @default.
• W2162223306 cites W2008150903 @default.
• W2162223306 cites W2009904653 @default.
• W2162223306 cites W2011881359 @default.
• W2162223306 cites W2015619236 @default.
• W2162223306 cites W2018155342 @default.
• W2162223306 cites W2018293959 @default.
• W2162223306 cites W2025130128 @default.
• W2162223306 cites W2025637090 @default.
• W2162223306 cites W2027215054 @default.
• W2162223306 cites W2030314926 @default.
• W2162223306 cites W2033469243 @default.
• W2162223306 cites W2033841378 @default.
• W2162223306 cites W2034733431 @default.
• W2162223306 cites W2038444011 @default.
• W2162223306 cites W2038449110 @default.
• W2162223306 cites W2046662935 @default.
• W2162223306 cites W2046670941 @default.
• W2162223306 cites W2055079819 @default.
• W2162223306 cites W2062677725 @default.
• W2162223306 cites W2068063049 @default.
• W2162223306 cites W2068595115 @default.
• W2162223306 cites W2070616469 @default.
• W2162223306 cites W2071689931 @default.
• W2162223306 cites W2076263545 @default.
• W2162223306 cites W2083081277 @default.
• W2162223306 cites W2085385243 @default.
• W2162223306 cites W2086271423 @default.
• W2162223306 cites W2086837082 @default.
• W2162223306 cites W2088732407 @default.
• W2162223306 cites W2092061680 @default.
• W2162223306 cites W2124607054 @default.
• W2162223306 cites W2125111589 @default.
• W2162223306 cites W2139554885 @default.
• W2162223306 cites W2147302318 @default.
• W2162223306 cites W2150922701 @default.
• W2162223306 cites W2158226610 @default.
• W2162223306 cites W2158614841 @default.
• W2162223306 cites W2341699965 @default.
• W2162223306 cites W2403013080 @default.
• W2162223306 cites W2409641548 @default.
• W2162223306 cites W4244363769 @default.
• W2162223306 cites W55200214 @default.
• W2162223306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1888102" @default.
• W2162223306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3946557" @default.
• W2162223306 hasPublicationYear "1986" @default.
• W2162223306 type Work @default.
• W2162223306 sameAs 2162223306 @default.
• W2162223306 citedByCount "89" @default.
• W2162223306 countsByYear W21622233062013 @default.
• W2162223306 countsByYear W21622233062014 @default.
• W2162223306 countsByYear W21622233062015 @default.
• W2162223306 countsByYear W21622233062016 @default.
• W2162223306 countsByYear W21622233062018 @default.
• W2162223306 countsByYear W21622233062021 @default.
• W2162223306 countsByYear W21622233062022 @default.
• W2162223306 countsByYear W21622233062023 @default.
• W2162223306 crossrefType "journal-article" @default.
• W2162223306 hasAuthorship W2162223306A5011357491 @default.
• W2162223306 hasAuthorship W2162223306A5018898924 @default.
• W2162223306 hasAuthorship W2162223306A5028238095 @default.
• W2162223306 hasAuthorship W2162223306A5032350824 @default.
• W2162223306 hasAuthorship W2162223306A5053072500 @default.
• W2162223306 hasConcept C104317684 @default.
• W2162223306 hasConcept C124964019 @default.
• W2162223306 hasConcept C136403682 @default.
• W2162223306 hasConcept C137061746 @default.
• W2162223306 hasConcept C148738053 @default.
• W2162223306 hasConcept C1491633281 @default.
• W2162223306 hasConcept C181199279 @default.
• W2162223306 hasConcept C19702531 @default.
• W2162223306 hasConcept C202751555 @default.
• W2162223306 hasConcept C203014093 @default.
• W2162223306 hasConcept C21547065 @default.
• W2162223306 hasConcept C2776033226 @default.
• W2162223306 hasConcept C54355233 @default.
• W2162223306 hasConcept C55493867 @default.
• W2162223306 hasConcept C77076574 @default.
• W2162223306 hasConcept C86803240 @default.
• W2162223306 hasConcept C91999924 @default.
• W2162223306 hasConcept C95444343 @default.
• W2162223306 hasConceptScore W2162223306C104317684 @default.

• next