FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162227712> ?p ?o ?g. }

• W2162227712 endingPage "242" @default.
• W2162227712 startingPage "238" @default.
• W2162227712 abstract "Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently induce intense hunger and subsequent food intake. Consistent with their obligatory role in regulating appetite, genetic ablation or chemogenetic inhibition of AgRP neurons decreases feeding. Excitatory input to AgRP neurons is important in caloric-deficiency-induced activation, and is notable for its remarkable degree of caloric-state-dependent synaptic plasticity. Despite the important role of excitatory input, its source(s) has been unknown. Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1). Chemogenetic stimulation of these afferent neurons in sated mice markedly activates AgRP neurons and induces intense feeding. Conversely, acute inhibition in mice with caloric-deficiency-induced hunger decreases feeding. Discovery of these afferent neurons capable of triggering hunger advances understanding of how this intense motivational state is regulated." @default.
• W2162227712 created "2016-06-24" @default.
• W2162227712 creator A5009341389 @default.
• W2162227712 creator A5023541129 @default.
• W2162227712 creator A5024782501 @default.
• W2162227712 creator A5035147863 @default.
• W2162227712 creator A5038901409 @default.
• W2162227712 creator A5044286863 @default.
• W2162227712 creator A5045265531 @default.
• W2162227712 creator A5053834973 @default.
• W2162227712 creator A5061951793 @default.
• W2162227712 creator A5077602516 @default.
• W2162227712 creator A5079375788 @default.
• W2162227712 creator A5085316776 @default.
• W2162227712 date "2014-02-02" @default.
• W2162227712 modified "2023-10-16" @default.
• W2162227712 title "An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger" @default.
• W2162227712 cites W1499189927 @default.
• W2162227712 cites W1502937202 @default.
• W2162227712 cites W1967718477 @default.
• W2162227712 cites W1981415589 @default.
• W2162227712 cites W1994744366 @default.
• W2162227712 cites W1995026750 @default.
• W2162227712 cites W1997128521 @default.
• W2162227712 cites W2007161557 @default.
• W2162227712 cites W2021519886 @default.
• W2162227712 cites W2021631954 @default.
• W2162227712 cites W2035541519 @default.
• W2162227712 cites W2048073651 @default.
• W2162227712 cites W2061072142 @default.
• W2162227712 cites W2064842282 @default.
• W2162227712 cites W2069072617 @default.
• W2162227712 cites W2072527501 @default.
• W2162227712 cites W2076262535 @default.
• W2162227712 cites W2084615691 @default.
• W2162227712 cites W2089837563 @default.
• W2162227712 cites W2106505481 @default.
• W2162227712 cites W2109627278 @default.
• W2162227712 cites W2118827063 @default.
• W2162227712 cites W2121379737 @default.
• W2162227712 cites W2127818104 @default.
• W2162227712 cites W2139359479 @default.
• W2162227712 cites W2141060229 @default.
• W2162227712 cites W2141166900 @default.
• W2162227712 cites W2143060854 @default.
• W2162227712 cites W2150626351 @default.
• W2162227712 cites W2153274139 @default.
• W2162227712 cites W2163438163 @default.
• W2162227712 cites W2171804530 @default.
• W2162227712 cites W2278373599 @default.
• W2162227712 doi "https://doi.org/10.1038/nature12956" @default.
• W2162227712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3955843" @default.
• W2162227712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24487620" @default.
• W2162227712 hasPublicationYear "2014" @default.
• W2162227712 type Work @default.
• W2162227712 sameAs 2162227712 @default.
• W2162227712 citedByCount "492" @default.
• W2162227712 countsByYear W21622277122014 @default.
• W2162227712 countsByYear W21622277122015 @default.
• W2162227712 countsByYear W21622277122016 @default.
• W2162227712 countsByYear W21622277122017 @default.
• W2162227712 countsByYear W21622277122018 @default.
• W2162227712 countsByYear W21622277122019 @default.
• W2162227712 countsByYear W21622277122020 @default.
• W2162227712 countsByYear W21622277122021 @default.
• W2162227712 countsByYear W21622277122022 @default.
• W2162227712 countsByYear W21622277122023 @default.
• W2162227712 crossrefType "journal-article" @default.
• W2162227712 hasAuthorship W2162227712A5009341389 @default.
• W2162227712 hasAuthorship W2162227712A5023541129 @default.
• W2162227712 hasAuthorship W2162227712A5024782501 @default.
• W2162227712 hasAuthorship W2162227712A5035147863 @default.
• W2162227712 hasAuthorship W2162227712A5038901409 @default.
• W2162227712 hasAuthorship W2162227712A5044286863 @default.
• W2162227712 hasAuthorship W2162227712A5045265531 @default.
• W2162227712 hasAuthorship W2162227712A5053834973 @default.
• W2162227712 hasAuthorship W2162227712A5061951793 @default.
• W2162227712 hasAuthorship W2162227712A5077602516 @default.
• W2162227712 hasAuthorship W2162227712A5079375788 @default.
• W2162227712 hasAuthorship W2162227712A5085316776 @default.
• W2162227712 hasBestOaLocation W21622277122 @default.
• W2162227712 hasConcept C112592302 @default.
• W2162227712 hasConcept C126322002 @default.
• W2162227712 hasConcept C134018914 @default.
• W2162227712 hasConcept C169760540 @default.
• W2162227712 hasConcept C17077164 @default.
• W2162227712 hasConcept C185592680 @default.
• W2162227712 hasConcept C24998067 @default.
• W2162227712 hasConcept C2524010 @default.
• W2162227712 hasConcept C2777003273 @default.
• W2162227712 hasConcept C2778458369 @default.
• W2162227712 hasConcept C2778794669 @default.
• W2162227712 hasConcept C2780723820 @default.
• W2162227712 hasConcept C33923547 @default.
• W2162227712 hasConcept C71924100 @default.
• W2162227712 hasConcept C83415579 @default.
• W2162227712 hasConcept C86803240 @default.
• W2162227712 hasConceptScore W2162227712C112592302 @default.

• next