Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162232204> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2162232204 endingPage "3055" @default.
- W2162232204 startingPage "3047" @default.
- W2162232204 abstract "Abstract Previous studies using tyrosine phosphatase inhibitors have implicated tyrosine phosphatases in the signal transduction pathway initiated by aggregation of Fc epsilon RI, the high affinity receptor for IgE. To define more precisely a role for the tyrosine phosphatase CD45 in Fc epsilon RI-mediated signaling, we have transfected the three subunits of Fc epsilon RI into wild-type Jurkat and a CD45-deficient Jurkat derivative. Here we demonstrate that CD45 is necessary for the initiation of calcium flux through the transfected Fc epsilon RI. In contrast to the effect of phosphatase inhibitors, the tyrosine phosphorylation levels of beta and gamma after aggregation of Fc epsilon RI are surprisingly reduced, relative to wild-type Jurkat, in the CD45-deficient cells. After reconstitution of the CD45-deficient cells with a chimeric molecule containing the cytoplasmic phosphatase domains of CD45, both the base line and activation-induced tyrosine phosphorylation levels are increased. By examining Lck autophosphorylation, we find that Fc epsilon RI aggregation induces an increase in Lck enzymatic activity only in wild-type Jurkat and the CD45-deficient Jurkat reconstituted with chimeric CD45. This regulation of src-family tyrosine kinase activity may be the means by which CD45 controls aggregation-induced receptor phosphorylation." @default.
- W2162232204 created "2016-06-24" @default.
- W2162232204 creator A5071183748 @default.
- W2162232204 creator A5087038094 @default.
- W2162232204 creator A5088268437 @default.
- W2162232204 creator A5088748499 @default.
- W2162232204 date "1995-04-01" @default.
- W2162232204 modified "2023-10-17" @default.
- W2162232204 title "Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains." @default.
- W2162232204 doi "https://doi.org/10.4049/jimmunol.154.7.3047" @default.
- W2162232204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7897197" @default.
- W2162232204 hasPublicationYear "1995" @default.
- W2162232204 type Work @default.
- W2162232204 sameAs 2162232204 @default.
- W2162232204 citedByCount "28" @default.
- W2162232204 countsByYear W21622322042020 @default.
- W2162232204 countsByYear W21622322042022 @default.
- W2162232204 crossrefType "journal-article" @default.
- W2162232204 hasAuthorship W2162232204A5071183748 @default.
- W2162232204 hasAuthorship W2162232204A5087038094 @default.
- W2162232204 hasAuthorship W2162232204A5088268437 @default.
- W2162232204 hasAuthorship W2162232204A5088748499 @default.
- W2162232204 hasBestOaLocation W21622322041 @default.
- W2162232204 hasConcept C11960822 @default.
- W2162232204 hasConcept C150109051 @default.
- W2162232204 hasConcept C153911025 @default.
- W2162232204 hasConcept C178666793 @default.
- W2162232204 hasConcept C179464577 @default.
- W2162232204 hasConcept C185592680 @default.
- W2162232204 hasConcept C19317047 @default.
- W2162232204 hasConcept C203014093 @default.
- W2162232204 hasConcept C2776090121 @default.
- W2162232204 hasConcept C2776165026 @default.
- W2162232204 hasConcept C2777553839 @default.
- W2162232204 hasConcept C42362537 @default.
- W2162232204 hasConcept C55493867 @default.
- W2162232204 hasConcept C62478195 @default.
- W2162232204 hasConcept C85528070 @default.
- W2162232204 hasConcept C86803240 @default.
- W2162232204 hasConcept C8891405 @default.
- W2162232204 hasConcept C95444343 @default.
- W2162232204 hasConcept C97029542 @default.
- W2162232204 hasConceptScore W2162232204C11960822 @default.
- W2162232204 hasConceptScore W2162232204C150109051 @default.
- W2162232204 hasConceptScore W2162232204C153911025 @default.
- W2162232204 hasConceptScore W2162232204C178666793 @default.
- W2162232204 hasConceptScore W2162232204C179464577 @default.
- W2162232204 hasConceptScore W2162232204C185592680 @default.
- W2162232204 hasConceptScore W2162232204C19317047 @default.
- W2162232204 hasConceptScore W2162232204C203014093 @default.
- W2162232204 hasConceptScore W2162232204C2776090121 @default.
- W2162232204 hasConceptScore W2162232204C2776165026 @default.
- W2162232204 hasConceptScore W2162232204C2777553839 @default.
- W2162232204 hasConceptScore W2162232204C42362537 @default.
- W2162232204 hasConceptScore W2162232204C55493867 @default.
- W2162232204 hasConceptScore W2162232204C62478195 @default.
- W2162232204 hasConceptScore W2162232204C85528070 @default.
- W2162232204 hasConceptScore W2162232204C86803240 @default.
- W2162232204 hasConceptScore W2162232204C8891405 @default.
- W2162232204 hasConceptScore W2162232204C95444343 @default.
- W2162232204 hasConceptScore W2162232204C97029542 @default.
- W2162232204 hasIssue "7" @default.
- W2162232204 hasLocation W21622322041 @default.
- W2162232204 hasLocation W21622322042 @default.
- W2162232204 hasOpenAccess W2162232204 @default.
- W2162232204 hasPrimaryLocation W21622322041 @default.
- W2162232204 hasRelatedWork W1580168755 @default.
- W2162232204 hasRelatedWork W2027995286 @default.
- W2162232204 hasRelatedWork W2035962909 @default.
- W2162232204 hasRelatedWork W2046914298 @default.
- W2162232204 hasRelatedWork W2063872168 @default.
- W2162232204 hasRelatedWork W2064460444 @default.
- W2162232204 hasRelatedWork W2094162913 @default.
- W2162232204 hasRelatedWork W2183062661 @default.
- W2162232204 hasRelatedWork W2392029702 @default.
- W2162232204 hasRelatedWork W4313376294 @default.
- W2162232204 hasVolume "154" @default.
- W2162232204 isParatext "false" @default.
- W2162232204 isRetracted "false" @default.
- W2162232204 magId "2162232204" @default.
- W2162232204 workType "article" @default.