FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162236733> ?p ?o ?g. }

• W2162236733 abstract "To determine the role of autoantibody tests for autoimmune diseases in children with newly diagnosed type 1 diabetes mellitus.MEDLINE, EMBASE and the Cochrane Library. Citation lists of included studies were scanned and relevant professional and patient websites reviewed. Laboratories and manufacturers were contacted to identify ongoing or unpublished research.Following scoping searches on thyroid and coeliac autoantibodies, a systematic review of autoantibody tests for diagnosis of coeliac disease was carried out. Studies were included where cohorts of untreated patients with unknown disease status were included, all patients had undergone the reference test (biopsy) and antibody tests, and sensitivity and specificity were reported or calculable. Selected studies were then evaluated against a quality checklist. Summary statistics of diagnostic accuracy, i.e. sensitivity, specificity, positive and negative likelihood ratios and diagnostic odds ratios, were calculated for all studies. A decision analytic model was developed to evaluate the cost utility of screening for coeliac disease at diagnosis of diabetes.All antibody tests for diagnosis of coeliac disease showed reasonably good diagnostic test accuracy. Studies reported variable measures of test accuracy, which may be due to aspects of study quality, differences in the tests and their execution in the laboratories, different populations and reference standards. The decision analytic model indicated screening for coeliac disease at diagnosis of diabetes was cost-effective. Sensitivity analyses exploring variations in the cost and disutility of gluten-free diet, the utilities attached to treated and untreated coeliac disease and the decrease in life expectancy associated with treated and untreated coeliac disease did substantially affect the cost-effectiveness of the screening strategies considered.In terms of test accuracy in testing for coeliac disease, immunoglobulin A (IgA) anti-endomysium is the most accurate test. If an enzyme-linked immunoassay test was required, which may be more suitable for screening purposes as it can be semi-automated, testing for IgA tissue transglutaminase is likely to be most accurate. The decision analytic model shows that the most accurate tests combined with confirmatory biopsy are the most cost-effective, whilst combinations of tests add little or no further value. There is limited information regarding test accuracy in screening populations with diabetes, and there is some uncertainty over whether the test characteristics would remain the same. Further research is required regarding the role of screening in silent coeliac disease and regarding long-term outcomes and complications of untreated coeliac disease." @default.
• W2162236733 created "2016-06-24" @default.
• W2162236733 creator A5022963570 @default.
• W2162236733 creator A5024713442 @default.
• W2162236733 creator A5026203609 @default.
• W2162236733 creator A5028984464 @default.
• W2162236733 creator A5066938458 @default.
• W2162236733 creator A5068920522 @default.
• W2162236733 date "2004-06-01" @default.
• W2162236733 modified "2023-09-25" @default.
• W2162236733 title "Autoantibody testing in children with newly diagnosed type 1 diabetes mellitus" @default.
• W2162236733 cites W131464745 @default.
• W2162236733 cites W1488603340 @default.
• W2162236733 cites W1510386142 @default.
• W2162236733 cites W1521266957 @default.
• W2162236733 cites W1524506629 @default.
• W2162236733 cites W1541080151 @default.
• W2162236733 cites W1966444218 @default.
• W2162236733 cites W1969006368 @default.
• W2162236733 cites W1972698098 @default.
• W2162236733 cites W1973185874 @default.
• W2162236733 cites W1976101978 @default.
• W2162236733 cites W1981531564 @default.
• W2162236733 cites W1989781627 @default.
• W2162236733 cites W1993282245 @default.
• W2162236733 cites W1993553202 @default.
• W2162236733 cites W1995067043 @default.
• W2162236733 cites W1996151477 @default.
• W2162236733 cites W2001597243 @default.
• W2162236733 cites W2002020452 @default.
• W2162236733 cites W2007193922 @default.
• W2162236733 cites W2007476930 @default.
• W2162236733 cites W2009203131 @default.
• W2162236733 cites W2013711067 @default.
• W2162236733 cites W2016963118 @default.
• W2162236733 cites W2020628724 @default.
• W2162236733 cites W2027666532 @default.
• W2162236733 cites W2027904579 @default.
• W2162236733 cites W2028479357 @default.
• W2162236733 cites W2041422879 @default.
• W2162236733 cites W2041614578 @default.
• W2162236733 cites W2042887042 @default.
• W2162236733 cites W2048594834 @default.
• W2162236733 cites W2060335948 @default.
• W2162236733 cites W2061446065 @default.
• W2162236733 cites W2086426432 @default.
• W2162236733 cites W2098590161 @default.
• W2162236733 cites W2112546627 @default.
• W2162236733 cites W2113839048 @default.
• W2162236733 cites W2115447875 @default.
• W2162236733 cites W2119297205 @default.
• W2162236733 cites W2119404638 @default.
• W2162236733 cites W2130408763 @default.
• W2162236733 cites W2136935040 @default.
• W2162236733 cites W2137935440 @default.
• W2162236733 cites W2141649614 @default.
• W2162236733 cites W2144098375 @default.
• W2162236733 cites W2150427554 @default.
• W2162236733 cites W2153308144 @default.
• W2162236733 cites W2160550562 @default.
• W2162236733 cites W2162777356 @default.
• W2162236733 cites W2168300234 @default.
• W2162236733 cites W2169495405 @default.
• W2162236733 cites W2314780373 @default.
• W2162236733 cites W2315329255 @default.
• W2162236733 cites W2324712985 @default.
• W2162236733 cites W2325625973 @default.
• W2162236733 cites W2328261242 @default.
• W2162236733 cites W2407404794 @default.
• W2162236733 cites W2409550410 @default.
• W2162236733 cites W2410771478 @default.
• W2162236733 cites W2410808364 @default.
• W2162236733 cites W2411310953 @default.
• W2162236733 cites W2437485852 @default.
• W2162236733 cites W84598814 @default.
• W2162236733 cites W2105552450 @default.
• W2162236733 cites W2182118126 @default.
• W2162236733 cites W265433162 @default.
• W2162236733 cites W42434282 @default.
• W2162236733 doi "https://doi.org/10.3310/hta8220" @default.
• W2162236733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15191683" @default.
• W2162236733 hasPublicationYear "2004" @default.
• W2162236733 type Work @default.
• W2162236733 sameAs 2162236733 @default.
• W2162236733 citedByCount "71" @default.
• W2162236733 countsByYear W21622367332012 @default.
• W2162236733 countsByYear W21622367332014 @default.
• W2162236733 countsByYear W21622367332015 @default.
• W2162236733 countsByYear W21622367332017 @default.
• W2162236733 countsByYear W21622367332018 @default.
• W2162236733 countsByYear W21622367332019 @default.
• W2162236733 countsByYear W21622367332020 @default.
• W2162236733 crossrefType "journal-article" @default.
• W2162236733 hasAuthorship W2162236733A5022963570 @default.
• W2162236733 hasAuthorship W2162236733A5024713442 @default.
• W2162236733 hasAuthorship W2162236733A5026203609 @default.
• W2162236733 hasAuthorship W2162236733A5028984464 @default.
• W2162236733 hasAuthorship W2162236733A5066938458 @default.
• W2162236733 hasAuthorship W2162236733A5068920522 @default.
• W2162236733 hasBestOaLocation W21622367331 @default.

• next