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- W2162238307 abstract "The clinical manifestations of atherosclerotic disease, that is, coronary artery disease, peripheral arterial disease, and ischemic stroke, remain the major causes of morbidity and mortality today, despite the currently available plethora of cardiovascular medications and the enormous joint efforts of physicians and scientists to diagnose early and treat this disease that has attained pandemic proportions. Besides targeting lipid-lowering as a cause of atherosclerotic disease, the current guidelines to treat atherosclerotic disease focus mainly on anti-ischemic and antithrombotic therapy, 2 conditions that appear when the disease has already progressed to the point of occluding an artery. Atherosclerosis is a chronic nonresolving inflammatory disease that is strongly associated with aging. Vascular inflammation is orchestrated by a cascade of cytokines and chemokines secreted by a plethora of vascular cells and immune cells. Targeting one or even several pathways apparently is not enough to reverse and efficiently treat atherosclerotic disease. Thus, it might be promising to test therapeutic strategies that simultaneously target various genes and cell types." @default.
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- W2162238307 date "2014-01-03" @default.
- W2162238307 modified "2023-09-24" @default.
- W2162238307 title "Vascular MicroRNAs" @default.
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- W2162238307 doi "https://doi.org/10.1161/circresaha.113.302762" @default.
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