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- W2162243344 abstract "Tyrosinase inhibitors have potential applications in the cosmetics and food industries for preventing browning reactions and also as therapeutic drugs for neurodegenerative diseases such as Parkinson's. In this article, crocin and curcumin were evaluated as mushroom tyrosinase inhibitors. Results showed that, both compounds strongly inhibited the diphenolase activity than monophenolase. The IC50 values for diphenolase activity were estimated to be 0.11 mM and 0.18 mM for crocin and curcumin respectively. The binding kinetics of crocin and curcumin was studied with mushroom tyrosinase using surface plasmon resonance (SPR). Tyrosinase was immobilized on the gold surface of a Biacore sensor chip through amine coupling. Binding of inhibitors was analyzed by SPR without the need to further modify the surface or the use of other reagents. The binding constant KD (M) for mushroom tyrosinase obtained was 1.21 × 10−4 M for crocin and 1.64 × 10−4 M for curcumin, while showing a higher affinity for L-DOPA 1.95 × 10−8 M, a substrate for tyrosinase (positive control). The study reveals the SPR sensor's ability to detect binding of the inhibitors." @default.
- W2162243344 created "2016-06-24" @default.
- W2162243344 creator A5033427363 @default.
- W2162243344 creator A5066749033 @default.
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- W2162243344 date "2014-04-01" @default.
- W2162243344 modified "2023-10-17" @default.
- W2162243344 title "Evaluation of crocin and curcumin affinity on mushroom tyrosinase using surface plasmon resonance" @default.
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- W2162243344 doi "https://doi.org/10.1016/j.ijbiomac.2014.01.028" @default.
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