Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162250897> ?p ?o ?g. }
- W2162250897 endingPage "138" @default.
- W2162250897 startingPage "133" @default.
- W2162250897 abstract "We had reported that increased levels of endogenous ghrelin during the progression of doxorubicin-induced cardiomyopathy and heart failure might provide a compensatory self-protective effect. We investigated which pathway(s) produced these protective effects in vitro. Primary cultured cardiomyocytes were induced with doxorubicin in the presence or absence of ghrelin or a tumor necrosis factor-alpha (TNF-alpha) antagonist (etanercept). Ghrelin up-regulated TNF-alpha in a time- and dose-dependent manner. It significantly reduced cell apoptosis and markers of oxidative stress, such as malondialdehyde (MDA) content and lactate dehydrogenase (LDH) activity; it also increased anti-oxidative enzyme activity such as superoxide dismutase (MnSOD) and catalase (CAT), retained mitochondrial membrane potential and energy metabolism compared with doxorubicin alone. Moreover, ghrelin increased mitochondrial anti-apoptosis related gene protein expression such as bcl-2 and MnSOD, reduced cytoplasmic cytochrome C (Cyt C) release and strengthened the activation of NF-κB. All these effects were abrogated by etanercept. This suggests ghrelin affects the TNF-alpha/NF-κB activation pathways, up-regulating TNF-alpha, to produce anti-oxidative and anti-apoptotic effects that protected cardiomyocytes from doxorubicin-induced cytotoxicity." @default.
- W2162250897 created "2016-06-24" @default.
- W2162250897 creator A5005658991 @default.
- W2162250897 creator A5029679813 @default.
- W2162250897 creator A5033926422 @default.
- W2162250897 creator A5037817685 @default.
- W2162250897 creator A5051051037 @default.
- W2162250897 creator A5062627778 @default.
- W2162250897 creator A5073070644 @default.
- W2162250897 creator A5079940252 @default.
- W2162250897 date "2008-05-01" @default.
- W2162250897 modified "2023-09-23" @default.
- W2162250897 title "Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-κB pathways and mitochondrial protective mechanisms" @default.
- W2162250897 cites W1499561015 @default.
- W2162250897 cites W1966687534 @default.
- W2162250897 cites W1966825452 @default.
- W2162250897 cites W1971036847 @default.
- W2162250897 cites W1973118925 @default.
- W2162250897 cites W1979129905 @default.
- W2162250897 cites W1979588112 @default.
- W2162250897 cites W1980608195 @default.
- W2162250897 cites W1982624261 @default.
- W2162250897 cites W1984581009 @default.
- W2162250897 cites W1993615583 @default.
- W2162250897 cites W1995379683 @default.
- W2162250897 cites W1997816335 @default.
- W2162250897 cites W2006300648 @default.
- W2162250897 cites W2011349252 @default.
- W2162250897 cites W2032531389 @default.
- W2162250897 cites W2034454285 @default.
- W2162250897 cites W2041657104 @default.
- W2162250897 cites W2051867686 @default.
- W2162250897 cites W2054899525 @default.
- W2162250897 cites W2055075631 @default.
- W2162250897 cites W2060405870 @default.
- W2162250897 cites W2063454939 @default.
- W2162250897 cites W2072001961 @default.
- W2162250897 cites W2080113595 @default.
- W2162250897 cites W2080916834 @default.
- W2162250897 cites W2080941417 @default.
- W2162250897 cites W2083658751 @default.
- W2162250897 cites W2085171952 @default.
- W2162250897 cites W2109993485 @default.
- W2162250897 cites W2124928988 @default.
- W2162250897 cites W2129389766 @default.
- W2162250897 cites W2134339845 @default.
- W2162250897 cites W2142420952 @default.
- W2162250897 cites W2147155927 @default.
- W2162250897 cites W2159513257 @default.
- W2162250897 cites W2160302801 @default.
- W2162250897 cites W2161896823 @default.
- W2162250897 cites W2162282723 @default.
- W2162250897 cites W2163865122 @default.
- W2162250897 cites W2166021995 @default.
- W2162250897 cites W2166601632 @default.
- W2162250897 cites W2324476825 @default.
- W2162250897 cites W2499505205 @default.
- W2162250897 doi "https://doi.org/10.1016/j.tox.2008.02.018" @default.
- W2162250897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18400355" @default.
- W2162250897 hasPublicationYear "2008" @default.
- W2162250897 type Work @default.
- W2162250897 sameAs 2162250897 @default.
- W2162250897 citedByCount "100" @default.
- W2162250897 countsByYear W21622508972012 @default.
- W2162250897 countsByYear W21622508972013 @default.
- W2162250897 countsByYear W21622508972014 @default.
- W2162250897 countsByYear W21622508972015 @default.
- W2162250897 countsByYear W21622508972016 @default.
- W2162250897 countsByYear W21622508972017 @default.
- W2162250897 countsByYear W21622508972018 @default.
- W2162250897 countsByYear W21622508972019 @default.
- W2162250897 countsByYear W21622508972020 @default.
- W2162250897 countsByYear W21622508972021 @default.
- W2162250897 countsByYear W21622508972022 @default.
- W2162250897 countsByYear W21622508972023 @default.
- W2162250897 crossrefType "journal-article" @default.
- W2162250897 hasAuthorship W2162250897A5005658991 @default.
- W2162250897 hasAuthorship W2162250897A5029679813 @default.
- W2162250897 hasAuthorship W2162250897A5033926422 @default.
- W2162250897 hasAuthorship W2162250897A5037817685 @default.
- W2162250897 hasAuthorship W2162250897A5051051037 @default.
- W2162250897 hasAuthorship W2162250897A5062627778 @default.
- W2162250897 hasAuthorship W2162250897A5073070644 @default.
- W2162250897 hasAuthorship W2162250897A5079940252 @default.
- W2162250897 hasConcept C126322002 @default.
- W2162250897 hasConcept C134018914 @default.
- W2162250897 hasConcept C17991360 @default.
- W2162250897 hasConcept C181199279 @default.
- W2162250897 hasConcept C185592680 @default.
- W2162250897 hasConcept C190283241 @default.
- W2162250897 hasConcept C2775838275 @default.
- W2162250897 hasConcept C2776151105 @default.
- W2162250897 hasConcept C2776694085 @default.
- W2162250897 hasConcept C2777318727 @default.
- W2162250897 hasConcept C2778401633 @default.
- W2162250897 hasConcept C2779357093 @default.
- W2162250897 hasConcept C2781303535 @default.
- W2162250897 hasConcept C55493867 @default.