FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162251736> ?p ?o ?g. }

• W2162251736 endingPage "73" @default.
• W2162251736 startingPage "64" @default.
• W2162251736 abstract "OBJECTIVE We have previously shown that overnight fasted women have higher insulin-stimulated whole body and leg glucose uptake despite a higher intramyocellular triacylglycerol concentration than men. Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance. RESEARCH DESIGN AND METHODS Insulin sensitivity of whole-body and leg glucose disposal was studied in 16 young well-matched healthy men and women infused with intralipid or saline for 7 h. Muscle biopsies were obtained before and during a euglycemic-hyperinsulinemic clamp (1.42 mU · kg−1 · min−1). RESULTS Intralipid infusion reduced whole-body glucose infusion rate by 26% in women and 38% in men (P &lt; 0.05), and insulin-stimulated leg glucose uptake was reduced significantly less in women (45%) than men (60%) after intralipid infusion. Hepatic glucose production was decreased during the clamp similarly in women and men irrespective of intralipid infusion. Intralipid did not impair insulin or AMPK signaling in muscle and subcutaneous fat, did not cause accumulation of muscle lipid intermediates, and did not impair insulin-stimulated glycogen synthase activity in muscle or increase plasma concentrations of inflammatory cytokines. In vitro glucose transport in giant sarcolemmal vesicles was not decreased by acute exposure to fatty acids. Leg lactate release was increased and respiratory exchange ratio was decreased by intralipid. CONCLUSIONS Intralipid infusion causes less insulin resistance of muscle glucose uptake in women than in men. This insulin resistance is not due to decreased canonical insulin signaling, accumulation of lipid intermediates, inflammation, or direct inhibition of GLUT activity. Rather, a higher leg lactate release and lower glucose oxidation with intralipid infusion may suggest a metabolic feedback regulation of glucose metabolism." @default.
• W2162251736 created "2016-06-24" @default.
• W2162251736 creator A5012534532 @default.
• W2162251736 creator A5018757016 @default.
• W2162251736 creator A5027248926 @default.
• W2162251736 creator A5029794081 @default.
• W2162251736 creator A5038581645 @default.
• W2162251736 creator A5039041871 @default.
• W2162251736 creator A5046158740 @default.
• W2162251736 creator A5048291477 @default.
• W2162251736 creator A5060083223 @default.
• W2162251736 creator A5078725491 @default.
• W2162251736 creator A5081703415 @default.
• W2162251736 creator A5082949907 @default.
• W2162251736 date "2010-10-18" @default.
• W2162251736 modified "2023-10-16" @default.
• W2162251736 title "Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling" @default.
• W2162251736 cites W1575462042 @default.
• W2162251736 cites W1970409419 @default.
• W2162251736 cites W1971511295 @default.
• W2162251736 cites W1978495288 @default.
• W2162251736 cites W1999654071 @default.
• W2162251736 cites W2003585722 @default.
• W2162251736 cites W2009318817 @default.
• W2162251736 cites W2010996889 @default.
• W2162251736 cites W2012898950 @default.
• W2162251736 cites W2038372533 @default.
• W2162251736 cites W2044175256 @default.
• W2162251736 cites W2054538688 @default.
• W2162251736 cites W2060851332 @default.
• W2162251736 cites W2094632969 @default.
• W2162251736 cites W2095095532 @default.
• W2162251736 cites W2100583905 @default.
• W2162251736 cites W2101511370 @default.
• W2162251736 cites W2102526205 @default.
• W2162251736 cites W2108462699 @default.
• W2162251736 cites W2110549950 @default.
• W2162251736 cites W2112396418 @default.
• W2162251736 cites W2115433418 @default.
• W2162251736 cites W2120282127 @default.
• W2162251736 cites W2124557052 @default.
• W2162251736 cites W2125528261 @default.
• W2162251736 cites W2127056938 @default.
• W2162251736 cites W2127771448 @default.
• W2162251736 cites W2130850001 @default.
• W2162251736 cites W2141843769 @default.
• W2162251736 cites W2148383459 @default.
• W2162251736 cites W2160416826 @default.
• W2162251736 cites W2162361464 @default.
• W2162251736 cites W2170431161 @default.
• W2162251736 cites W2170651583 @default.
• W2162251736 cites W2214790450 @default.
• W2162251736 cites W4235264311 @default.
• W2162251736 doi "https://doi.org/10.2337/db10-0698" @default.
• W2162251736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3012198" @default.
• W2162251736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20956497" @default.
• W2162251736 hasPublicationYear "2010" @default.
• W2162251736 type Work @default.
• W2162251736 sameAs 2162251736 @default.
• W2162251736 citedByCount "112" @default.
• W2162251736 countsByYear W21622517362012 @default.
• W2162251736 countsByYear W21622517362013 @default.
• W2162251736 countsByYear W21622517362014 @default.
• W2162251736 countsByYear W21622517362015 @default.
• W2162251736 countsByYear W21622517362016 @default.
• W2162251736 countsByYear W21622517362017 @default.
• W2162251736 countsByYear W21622517362018 @default.
• W2162251736 countsByYear W21622517362019 @default.
• W2162251736 countsByYear W21622517362020 @default.
• W2162251736 countsByYear W21622517362021 @default.
• W2162251736 countsByYear W21622517362022 @default.
• W2162251736 countsByYear W21622517362023 @default.
• W2162251736 crossrefType "journal-article" @default.
• W2162251736 hasAuthorship W2162251736A5012534532 @default.
• W2162251736 hasAuthorship W2162251736A5018757016 @default.
• W2162251736 hasAuthorship W2162251736A5027248926 @default.
• W2162251736 hasAuthorship W2162251736A5029794081 @default.
• W2162251736 hasAuthorship W2162251736A5038581645 @default.
• W2162251736 hasAuthorship W2162251736A5039041871 @default.
• W2162251736 hasAuthorship W2162251736A5046158740 @default.
• W2162251736 hasAuthorship W2162251736A5048291477 @default.
• W2162251736 hasAuthorship W2162251736A5060083223 @default.
• W2162251736 hasAuthorship W2162251736A5078725491 @default.
• W2162251736 hasAuthorship W2162251736A5081703415 @default.
• W2162251736 hasAuthorship W2162251736A5082949907 @default.
• W2162251736 hasBestOaLocation W21622517361 @default.
• W2162251736 hasConcept C126322002 @default.
• W2162251736 hasConcept C134018914 @default.
• W2162251736 hasConcept C17093226 @default.
• W2162251736 hasConcept C192118531 @default.
• W2162251736 hasConcept C2777391703 @default.
• W2162251736 hasConcept C2777499176 @default.
• W2162251736 hasConcept C2777866211 @default.
• W2162251736 hasConcept C2778808658 @default.
• W2162251736 hasConcept C2779306644 @default.
• W2162251736 hasConcept C2780352109 @default.
• W2162251736 hasConcept C4733338 @default.
• W2162251736 hasConcept C71924100 @default.

• next