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• W2162263512 endingPage "e102022" @default.
• W2162263512 startingPage "e102022" @default.
• W2162263512 abstract "The early differentiation of T helper (Th) cells is a tightly controlled and finely balanced process, which involves several factors including cytokines, transcription factors and co-stimulatory molecules. Recent studies have shown that in addition to the regulation of apoptosis, caspase activity is also needed for Th cell proliferation and activation and it might play a role in Th cell differentiation. The isoforms of the cellular FLICE inhibitory protein (c-FLIP) are regulators of CASPASE-8 activity and the short isoform, c-FLIPS, has been shown to be up-regulated by IL-4, the Th2 driving cytokine. In this work, we have studied the expression and functional role of three c-FLIP isoforms during the early Th cell differentiation. Only two of the isoforms, c-FLIPS and c-FLIPL, were detected at the protein level although c-FLIPR was expressed at the mRNA level. The knockdown of c-FLIPL led to enhanced Th1 differentiation and elevated IL-4 production by Th2 cells, whereas the knockdown of c-FLIPS diminished GATA3 expression and IL-4 production by Th2 cells. In summary, our results provide new insight into the role of c-FLIP proteins in the early differentiation of human Th cells." @default.
• W2162263512 created "2016-06-24" @default.
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• W2162263512 date "2014-07-14" @default.
• W2162263512 modified "2023-09-26" @default.
• W2162263512 title "The Regulation and Role of c-FLIP in Human Th Cell Differentiation" @default.
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• W2162263512 doi "https://doi.org/10.1371/journal.pone.0102022" @default.
• W2162263512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096760" @default.
• W2162263512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25019384" @default.
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