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- W2162271105 abstract "The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-specific recognition of EIIIB as an exon. This motif enhances usage of the EIIIB 5' splice site; furthermore, this repeated TGCATG sequence can activate an alternatively spliced exon in the unrelated rat preprotachykinin pre-mRNA. Interestingly, this sequence can also be found within cis-acting elements identified previously in other alternatively spliced genes. This short repeated TGCATG motif is therefore a cell type-specific element that, in addition to controlling fibronectin alternative splicing, may participate in the regulation of other alternative RNA processing events." @default.
- W2162271105 created "2016-06-24" @default.
- W2162271105 creator A5016374010 @default.
- W2162271105 creator A5030647867 @default.
- W2162271105 date "1994-07-01" @default.
- W2162271105 modified "2023-10-18" @default.
- W2162271105 title "Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element." @default.
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- W2162271105 doi "https://doi.org/10.1101/gad.8.13.1561" @default.
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