FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162275477> ?p ?o ?g. }

• W2162275477 endingPage "8986" @default.
• W2162275477 startingPage "8980" @default.
• W2162275477 abstract "Using expression microarray, we have previously shown that human cyclin G2 (hCG2) is significantly down-regulated in laser capture microdissected oral cancer epithelia. Western analysis showed detectable hCG2 protein in normal (2 of 2) but not in malignant (4 of 4) oral keratinocyte cell lines. Immunohistochemistry analysis done on oral cancers showed that normal oral mucosa (100%, 12 of 12) and 69.1% (47 of 68) of dysplastic oral epithelia expressed readily detectable hCG2 in the nuclei. However, only 11.1% of oral cancer epithelia (14 of 126) showed mild hCG2 nuclear staining. Interestingly, of the oral cancers devoid of nuclear hCG2 (112 cases), 58 cases (52%) showed cytoplasmic hCG2 immunostaining, whereas the other 54 cases (48%) exhibited neither nuclear nor cytoplasmic hCG2 staining. In vitro functional study by ectopic restoration of hCG2 expression in the human malignant squamous cell carcinoma (SCC) line SCC15 resulted in a significant inhibition of cellular proliferation (P < 0.001) and colony formation (P < 2 x 10(-5)) with increased population of G(1) phase and decreased in S phase (P < 0.01). Furthermore, stable down-regulation of hCG2 by short interference RNA-based gene silencing in immortalized normal oral keratinocytes resulted in enhanced cell growth with increase in S and prominently in G(2) phase. Because hCG2 has been implicated as a negative regulator in cell cycle progression, our results support that hCG2 dysregulation may play an important role in epithelial transformation and the early stages of human oral cancer development." @default.
• W2162275477 created "2016-06-24" @default.
• W2162275477 creator A5007779785 @default.
• W2162275477 creator A5010339155 @default.
• W2162275477 creator A5049579503 @default.
• W2162275477 creator A5083967189 @default.
• W2162275477 creator A5087543035 @default.
• W2162275477 date "2004-12-15" @default.
• W2162275477 modified "2023-10-17" @default.
• W2162275477 title "Cyclin G2 Dysregulation in Human Oral Cancer" @default.
• W2162275477 cites W1496835012 @default.
• W2162275477 cites W1823168351 @default.
• W2162275477 cites W1974582859 @default.
• W2162275477 cites W1981798385 @default.
• W2162275477 cites W2000555456 @default.
• W2162275477 cites W2008590315 @default.
• W2162275477 cites W2025666038 @default.
• W2162275477 cites W2027558915 @default.
• W2162275477 cites W2043343878 @default.
• W2162275477 cites W2046009688 @default.
• W2162275477 cites W2053656109 @default.
• W2162275477 cites W2077902938 @default.
• W2162275477 cites W2087691380 @default.
• W2162275477 cites W2121071871 @default.
• W2162275477 cites W2125169413 @default.
• W2162275477 cites W2156105051 @default.
• W2162275477 cites W2161659436 @default.
• W2162275477 doi "https://doi.org/10.1158/0008-5472.can-04-1926" @default.
• W2162275477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15604262" @default.
• W2162275477 hasPublicationYear "2004" @default.
• W2162275477 type Work @default.
• W2162275477 sameAs 2162275477 @default.
• W2162275477 citedByCount "62" @default.
• W2162275477 countsByYear W21622754772012 @default.
• W2162275477 countsByYear W21622754772013 @default.
• W2162275477 countsByYear W21622754772014 @default.
• W2162275477 countsByYear W21622754772015 @default.
• W2162275477 countsByYear W21622754772016 @default.
• W2162275477 countsByYear W21622754772017 @default.
• W2162275477 countsByYear W21622754772018 @default.
• W2162275477 countsByYear W21622754772019 @default.
• W2162275477 countsByYear W21622754772020 @default.
• W2162275477 countsByYear W21622754772021 @default.
• W2162275477 crossrefType "journal-article" @default.
• W2162275477 hasAuthorship W2162275477A5007779785 @default.
• W2162275477 hasAuthorship W2162275477A5010339155 @default.
• W2162275477 hasAuthorship W2162275477A5049579503 @default.
• W2162275477 hasAuthorship W2162275477A5083967189 @default.
• W2162275477 hasAuthorship W2162275477A5087543035 @default.
• W2162275477 hasConcept C120504264 @default.
• W2162275477 hasConcept C121608353 @default.
• W2162275477 hasConcept C142724271 @default.
• W2162275477 hasConcept C153911025 @default.
• W2162275477 hasConcept C199835354 @default.
• W2162275477 hasConcept C203014093 @default.
• W2162275477 hasConcept C204232928 @default.
• W2162275477 hasConcept C2777074287 @default.
• W2162275477 hasConcept C2778437423 @default.
• W2162275477 hasConcept C2779409057 @default.
• W2162275477 hasConcept C29537977 @default.
• W2162275477 hasConcept C4224716 @default.
• W2162275477 hasConcept C502942594 @default.
• W2162275477 hasConcept C54355233 @default.
• W2162275477 hasConcept C62112901 @default.
• W2162275477 hasConcept C71924100 @default.
• W2162275477 hasConcept C81885089 @default.
• W2162275477 hasConcept C86803240 @default.
• W2162275477 hasConceptScore W2162275477C120504264 @default.
• W2162275477 hasConceptScore W2162275477C121608353 @default.
• W2162275477 hasConceptScore W2162275477C142724271 @default.
• W2162275477 hasConceptScore W2162275477C153911025 @default.
• W2162275477 hasConceptScore W2162275477C199835354 @default.
• W2162275477 hasConceptScore W2162275477C203014093 @default.
• W2162275477 hasConceptScore W2162275477C204232928 @default.
• W2162275477 hasConceptScore W2162275477C2777074287 @default.
• W2162275477 hasConceptScore W2162275477C2778437423 @default.
• W2162275477 hasConceptScore W2162275477C2779409057 @default.
• W2162275477 hasConceptScore W2162275477C29537977 @default.
• W2162275477 hasConceptScore W2162275477C4224716 @default.
• W2162275477 hasConceptScore W2162275477C502942594 @default.
• W2162275477 hasConceptScore W2162275477C54355233 @default.
• W2162275477 hasConceptScore W2162275477C62112901 @default.
• W2162275477 hasConceptScore W2162275477C71924100 @default.
• W2162275477 hasConceptScore W2162275477C81885089 @default.
• W2162275477 hasConceptScore W2162275477C86803240 @default.
• W2162275477 hasIssue "24" @default.
• W2162275477 hasLocation W21622754771 @default.
• W2162275477 hasLocation W21622754772 @default.
• W2162275477 hasOpenAccess W2162275477 @default.
• W2162275477 hasPrimaryLocation W21622754771 @default.
• W2162275477 hasRelatedWork W2113035533 @default.
• W2162275477 hasRelatedWork W2139803439 @default.
• W2162275477 hasRelatedWork W2225522708 @default.
• W2162275477 hasRelatedWork W2349862336 @default.
• W2162275477 hasRelatedWork W2369847242 @default.
• W2162275477 hasRelatedWork W2383820488 @default.
• W2162275477 hasRelatedWork W2783802064 @default.
• W2162275477 hasRelatedWork W3010117194 @default.

• next