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• W2162275942 abstract "The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA from 718 individuals, aged 25-92 years (mean = 55). We sequenced the methyl-CpG-enriched genomic DNA fraction, averaging 67.3 million reads per subject, to obtain methylation measurements for the ∼27 million autosomal CpGs in the human genome. Following extensive quality control, we adaptively combined methylation measures for neighboring, highly-correlated CpGs into 4 344 016 CpG blocks with which we performed association testing. Eleven age-associated differentially methylated regions (DMRs) passed Bonferroni correction (P-value < 1.15 × 10(-8)). Top findings replicated in an independent sample set of 558 subjects using pyrosequencing of bisulfite-converted DNA (min P-value < 10(-30)). To examine biological themes, we selected 70 DMRs with false discovery rate of <0.1. Of these, 42 showed hypomethylation and 28 showed hypermethylation with age. Hypermethylated DMRs were more likely to overlap with CpG islands and shores. Hypomethylated DMRs were more likely to be in regions associated with polycomb/regulatory proteins (e.g. EZH2) or histone modifications H3K27ac, H3K4m1, H3K4m2, H3K4m3 and H3K9ac. Among genes implicated by the top DMRs were protocadherins, homeobox genes, MAPKs and ryanodine receptors. Several of our DMRs are at genes with potential relevance for age-related disease. This study successfully demonstrates the application of next-generation sequencing to MWAS, by interrogating a large proportion of the methylome and returning potentially novel age DMRs, in addition to replicating several loci implicated in previous studies using microarrays." @default.
• W2162275942 created "2016-06-24" @default.
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• W2162275942 date "2013-10-16" @default.
• W2162275942 modified "2023-10-04" @default.
• W2162275942 title "A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects" @default.
• W2162275942 cites W1600472471 @default.
• W2162275942 cites W1964895626 @default.
• W2162275942 cites W1968018974 @default.
• W2162275942 cites W1974355024 @default.
• W2162275942 cites W1977887774 @default.
• W2162275942 cites W1979273476 @default.
• W2162275942 cites W1979360991 @default.
• W2162275942 cites W1986224715 @default.
• W2162275942 cites W1988354925 @default.
• W2162275942 cites W1990916340 @default.
• W2162275942 cites W2014327040 @default.
• W2162275942 cites W2014945558 @default.
• W2162275942 cites W2017138237 @default.
• W2162275942 cites W2026570544 @default.
• W2162275942 cites W2028418054 @default.
• W2162275942 cites W2028934624 @default.
• W2162275942 cites W2029033394 @default.
• W2162275942 cites W2029088468 @default.
• W2162275942 cites W2029309391 @default.
• W2162275942 cites W2030523067 @default.
• W2162275942 cites W2035280647 @default.
• W2162275942 cites W2039669402 @default.
• W2162275942 cites W2048945658 @default.
• W2162275942 cites W2050880607 @default.
• W2162275942 cites W2058414967 @default.
• W2162275942 cites W2065355024 @default.
• W2162275942 cites W2072472548 @default.
• W2162275942 cites W2073393965 @default.
• W2162275942 cites W2074746593 @default.
• W2162275942 cites W2080644309 @default.
• W2162275942 cites W2092975210 @default.
• W2162275942 cites W2093463665 @default.
• W2162275942 cites W2094038521 @default.
• W2162275942 cites W2095427541 @default.
• W2162275942 cites W2096107919 @default.
• W2162275942 cites W2098597355 @default.
• W2162275942 cites W2100212335 @default.
• W2162275942 cites W2109117027 @default.
• W2162275942 cites W2109715726 @default.
• W2162275942 cites W2110837219 @default.
• W2162275942 cites W2111465765 @default.
• W2162275942 cites W2115993158 @default.
• W2162275942 cites W2117792884 @default.
• W2162275942 cites W2118526609 @default.
• W2162275942 cites W2121091193 @default.
• W2162275942 cites W2125013655 @default.
• W2162275942 cites W2125700595 @default.
• W2162275942 cites W2125905177 @default.
• W2162275942 cites W2127835459 @default.
• W2162275942 cites W2130318163 @default.
• W2162275942 cites W2131187320 @default.
• W2162275942 cites W2132083557 @default.
• W2162275942 cites W2132261436 @default.
• W2162275942 cites W2132708409 @default.
• W2162275942 cites W2136434805 @default.
• W2162275942 cites W2136493937 @default.
• W2162275942 cites W2136691282 @default.
• W2162275942 cites W2136970997 @default.
• W2162275942 cites W2138134399 @default.
• W2162275942 cites W2138603354 @default.
• W2162275942 cites W2138708553 @default.
• W2162275942 cites W2144777717 @default.
• W2162275942 cites W2148521032 @default.
• W2162275942 cites W2155605783 @default.
• W2162275942 cites W2156165856 @default.
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• W2162275942 cites W2163125553 @default.
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• W2162275942 doi "https://doi.org/10.1093/hmg/ddt511" @default.
• W2162275942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919012" @default.
• W2162275942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24135035" @default.
• W2162275942 hasPublicationYear "2013" @default.
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