FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162287173> ?p ?o ?g. }

• W2162287173 endingPage "383" @default.
• W2162287173 startingPage "375" @default.
• W2162287173 abstract "Pneumococcal serine-rich repeat protein (PsrP) is a putative adhesin encoded in the Streptococcus pneumoniae pathogenicity island psrP-secY2A2. Challenge of mice with serotype 4, strain TIGR4, and the isogenic mutants T4ΔpsrP and T4ΔpsrP-secY2A2 determined that PsrP was required for bacterial persistence in the lungs but not for colonization in the nasopharynx or replication in the bloodstream during sepsis. In vitro experiments corroborated this anatomical site-specific role; psrP mutants failed to bind to A549 and LA-4 lung cells, yet adhered normally to human nasopharyngeal epithelial cells and to cells from human and rodent capillary endothelial cell lines. We determined that the amino terminus of PsrP mediated adhesion. Microspheres coated with recombinant PsrPSRR1-BR (rPsrPSRR1-BR) adhered to A549 cells, and moreover, preincubation of cells with rPsrPSRR1-BR inhibited TIGR4 adhesion in vitro. Antibodies against rPsrPSRR1-BR also neutralized PsrP function; antiserum against rPsrPSRR1-BR blocked TIGR4 adhesion in vitro and, following passive immunization, it protected mice against challenge. We conclude that PsrP is an adhesin required for bacterial persistence in the lungs and that rPsrPSRR1-BR is a protective antigen." @default.
• W2162287173 created "2016-06-24" @default.
• W2162287173 creator A5009841943 @default.
• W2162287173 creator A5032463863 @default.
• W2162287173 creator A5044057376 @default.
• W2162287173 creator A5048555409 @default.
• W2162287173 creator A5063035523 @default.
• W2162287173 creator A5063617875 @default.
• W2162287173 date "2008-08-01" @default.
• W2162287173 modified "2023-09-24" @default.
• W2162287173 title "Antibodies against PsrP, a Novel<i>Streptococcus pneumoniae</i>Adhesin, Block Adhesion and Protect Mice against Pneumococcal Challenge" @default.
• W2162287173 cites W1589675578 @default.
• W2162287173 cites W1907239588 @default.
• W2162287173 cites W1963268238 @default.
• W2162287173 cites W1969901275 @default.
• W2162287173 cites W1978465166 @default.
• W2162287173 cites W1988837048 @default.
• W2162287173 cites W1999375310 @default.
• W2162287173 cites W2015616512 @default.
• W2162287173 cites W2018975142 @default.
• W2162287173 cites W2024435379 @default.
• W2162287173 cites W2043214808 @default.
• W2162287173 cites W2101203381 @default.
• W2162287173 cites W2102275848 @default.
• W2162287173 cites W2108360478 @default.
• W2162287173 cites W2111281901 @default.
• W2162287173 cites W2112340752 @default.
• W2162287173 cites W2113326101 @default.
• W2162287173 cites W2114379764 @default.
• W2162287173 cites W2120151328 @default.
• W2162287173 cites W2120685671 @default.
• W2162287173 cites W2129816323 @default.
• W2162287173 cites W2135610044 @default.
• W2162287173 cites W2143304841 @default.
• W2162287173 cites W2144667661 @default.
• W2162287173 cites W2146544984 @default.
• W2162287173 cites W2152900186 @default.
• W2162287173 cites W2156770347 @default.
• W2162287173 cites W2161385708 @default.
• W2162287173 cites W2163290872 @default.
• W2162287173 cites W2167221249 @default.
• W2162287173 cites W2167866530 @default.
• W2162287173 cites W2168857380 @default.
• W2162287173 cites W4237880661 @default.
• W2162287173 doi "https://doi.org/10.1086/589775" @default.
• W2162287173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18507531" @default.
• W2162287173 hasPublicationYear "2008" @default.
• W2162287173 type Work @default.
• W2162287173 sameAs 2162287173 @default.
• W2162287173 citedByCount "88" @default.
• W2162287173 countsByYear W21622871732012 @default.
• W2162287173 countsByYear W21622871732013 @default.
• W2162287173 countsByYear W21622871732014 @default.
• W2162287173 countsByYear W21622871732015 @default.
• W2162287173 countsByYear W21622871732016 @default.
• W2162287173 countsByYear W21622871732017 @default.
• W2162287173 countsByYear W21622871732018 @default.
• W2162287173 countsByYear W21622871732019 @default.
• W2162287173 countsByYear W21622871732020 @default.
• W2162287173 countsByYear W21622871732021 @default.
• W2162287173 countsByYear W21622871732022 @default.
• W2162287173 countsByYear W21622871732023 @default.
• W2162287173 crossrefType "journal-article" @default.
• W2162287173 hasAuthorship W2162287173A5009841943 @default.
• W2162287173 hasAuthorship W2162287173A5032463863 @default.
• W2162287173 hasAuthorship W2162287173A5044057376 @default.
• W2162287173 hasAuthorship W2162287173A5048555409 @default.
• W2162287173 hasAuthorship W2162287173A5063035523 @default.
• W2162287173 hasAuthorship W2162287173A5063617875 @default.
• W2162287173 hasBestOaLocation W21622871731 @default.
• W2162287173 hasConcept C104317684 @default.
• W2162287173 hasConcept C159654299 @default.
• W2162287173 hasConcept C179470777 @default.
• W2162287173 hasConcept C202751555 @default.
• W2162287173 hasConcept C203014093 @default.
• W2162287173 hasConcept C2780868878 @default.
• W2162287173 hasConcept C2781253189 @default.
• W2162287173 hasConcept C501593827 @default.
• W2162287173 hasConcept C547475151 @default.
• W2162287173 hasConcept C55493867 @default.
• W2162287173 hasConcept C86803240 @default.
• W2162287173 hasConcept C89423630 @default.
• W2162287173 hasConceptScore W2162287173C104317684 @default.
• W2162287173 hasConceptScore W2162287173C159654299 @default.
• W2162287173 hasConceptScore W2162287173C179470777 @default.
• W2162287173 hasConceptScore W2162287173C202751555 @default.
• W2162287173 hasConceptScore W2162287173C203014093 @default.
• W2162287173 hasConceptScore W2162287173C2780868878 @default.
• W2162287173 hasConceptScore W2162287173C2781253189 @default.
• W2162287173 hasConceptScore W2162287173C501593827 @default.
• W2162287173 hasConceptScore W2162287173C547475151 @default.
• W2162287173 hasConceptScore W2162287173C55493867 @default.
• W2162287173 hasConceptScore W2162287173C86803240 @default.
• W2162287173 hasConceptScore W2162287173C89423630 @default.
• W2162287173 hasIssue "3" @default.
• W2162287173 hasLocation W21622871731 @default.
• W2162287173 hasLocation W21622871732 @default.
• W2162287173 hasOpenAccess W2162287173 @default.

• next