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• W2162289736 abstract "No AccessJournal of UrologyAdult Urology1 Mar 2014Prevalence and Management of Lower Urinary Tract Symptoms in Methamphetamine Abusers: An Under-Recognized Clinical Identity Kyo Chul Koo, Dong Hoon Lee, Jang Hwan Kim, Koon Ho Rha, Byung Ha Chung, Sung Joon Hong, and Sang Yol Mah Kyo Chul KooKyo Chul Koo Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea Drug and Substance Abuse Treatment and Rehabilitation Center, National Forensic Hospital, Banpo-meun, Gongju, Republic of Korea More articles by this author , Dong Hoon LeeDong Hoon Lee Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author , Jang Hwan KimJang Hwan Kim Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author , Koon Ho RhaKoon Ho Rha Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author , Byung Ha ChungByung Ha Chung Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author , Sung Joon HongSung Joon Hong Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author , and Sang Yol MahSang Yol Mah Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.08.020AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigate the prevalence of lower urinary tract symptoms in a cohort of methamphetamine abusers, and assess the therapeutic efficacy of α-blockers and anticholinergics. Materials and Methods: From May 2011 to March 2013, 78 male methamphetamine abusers diagnosed with methamphetamine addiction were identified at the National Forensic Hospital, Korea. The I-PSS (International Prostate Symptom Score) with consultation was used to investigate the prevalence of lower urinary tract symptoms, defined as total I-PSS 8 or greater and quality of life index score of 2 or greater. These values for methamphetamine abusers were compared to those of 71 age matched controls. α-Blockers and anticholinergics were administered to methamphetamine abusers with lower urinary tract symptoms according to predominant voiding and storage symptoms based on voiding-to-storage subscore ratios. For methamphetamine abusers with no response, defined as a reduction of 4 or less in total I-PSS, an alternative drug or combination was administered. Efficacy was assessed based on a 4-week interval. Results: The median periods of methamphetamine abuse and abstinence were 18.1 years and 5.7 months, respectively. Methamphetamine abusers showed a higher prevalence of lower urinary tract symptoms compared to controls (77% vs 15%, p <0.001), with higher I-PSS and quality of life index score (13.3 vs 5.6 and 2.9 vs 0.9, respectively; p <0.001). Anticholinergics showed the greatest effect on I-PSS reduction with overall response rates for α-blockers, anticholinergics and combinations of 13%, 61% and 14%, respectively. Seven (12%) methamphetamine abusers did not respond to any therapy. Conclusions: Lower urinary tract symptoms were highly prevalent among methamphetamine abusers. Our results imply that pathological dopaminergic mechanisms have a role in methamphetamine associated lower urinary tract symptoms. Moreover, first line anticholinergics and prompt combination with α-blockers conferred the most therapeutic benefit to nonresponders. 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Google Scholar © 2014 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 191Issue 3March 2014Page: 722-726 Advertisement Copyright & Permissions© 2014 by American Urological Association Education and Research, Inc.Keywordslower urinary tract symptomstreatment outcomemethamphetamineprevalenceMetricsAuthor Information Kyo Chul Koo Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea Drug and Substance Abuse Treatment and Rehabilitation Center, National Forensic Hospital, Banpo-meun, Gongju, Republic of Korea More articles by this author Dong Hoon Lee Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Jang Hwan Kim Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Koon Ho Rha Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Byung Ha Chung Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Sung Joon Hong Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Sang Yol Mah Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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