Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162290916> ?p ?o ?g. }
- W2162290916 abstract "Monozygotic (MZ) twins share nearly all of their genetic variants and many similar environments before and after birth. However, they can also show phenotypic discordance for a wide range of traits. Differences at the epigenetic level may account for such discordances. It is well established that epigenetic states can contribute to phenotypic variation, including disease. Epigenetic states are dynamic and potentially reversible marks involved in gene regulation, which can be influenced by genetics, environment, and stochastic events. Here, we review advances in epigenetic studies of discordant MZ twins, focusing on disease. The study of epigenetics and disease using discordant MZ twins offers the opportunity to control for many potential confounders encountered in general population studies, such as differences in genetic background, early-life environmental exposure, age, gender, and cohort effects. Recently, analysis of disease-discordant MZ twins has been successfully used to study epigenetic mechanisms in aging, cancer, autoimmune disease, psychiatric, neurological, and multiple other traits. Epigenetic aberrations have been found in a range of phenotypes, and challenges have been identified, including sampling time, tissue specificity, validation, and replication. The results have relevance for personalized medicine approaches, including the identification of prognostic, diagnostic, and therapeutic targets. The findings also help to identify epigenetic markers of environmental risk and molecular mechanisms involved in disease and disease progression, which have implications both for understanding disease and for future medical research." @default.
- W2162290916 created "2016-06-24" @default.
- W2162290916 creator A5002163035 @default.
- W2162290916 creator A5050019095 @default.
- W2162290916 creator A5076106859 @default.
- W2162290916 date "2014-07-01" @default.
- W2162290916 modified "2023-10-16" @default.
- W2162290916 title "Epigenetics of discordant monozygotic twins: implications for disease" @default.
- W2162290916 cites W1519629411 @default.
- W2162290916 cites W1588083350 @default.
- W2162290916 cites W1963970354 @default.
- W2162290916 cites W1964013868 @default.
- W2162290916 cites W1967064280 @default.
- W2162290916 cites W1967965584 @default.
- W2162290916 cites W1969510021 @default.
- W2162290916 cites W1974473791 @default.
- W2162290916 cites W1974747095 @default.
- W2162290916 cites W1979873290 @default.
- W2162290916 cites W1982860329 @default.
- W2162290916 cites W1983213171 @default.
- W2162290916 cites W1986095118 @default.
- W2162290916 cites W1989795189 @default.
- W2162290916 cites W1990654003 @default.
- W2162290916 cites W1991965466 @default.
- W2162290916 cites W1992822589 @default.
- W2162290916 cites W1995470989 @default.
- W2162290916 cites W1997824331 @default.
- W2162290916 cites W1999551423 @default.
- W2162290916 cites W2002698073 @default.
- W2162290916 cites W2006345816 @default.
- W2162290916 cites W2014852291 @default.
- W2162290916 cites W2022331234 @default.
- W2162290916 cites W2022787343 @default.
- W2162290916 cites W2022841432 @default.
- W2162290916 cites W2024065153 @default.
- W2162290916 cites W2028612889 @default.
- W2162290916 cites W2029007473 @default.
- W2162290916 cites W2031073218 @default.
- W2162290916 cites W2031191277 @default.
- W2162290916 cites W2031597554 @default.
- W2162290916 cites W2033162367 @default.
- W2162290916 cites W2034403814 @default.
- W2162290916 cites W2036079113 @default.
- W2162290916 cites W2043033879 @default.
- W2162290916 cites W2049259093 @default.
- W2162290916 cites W2050105063 @default.
- W2162290916 cites W2051406511 @default.
- W2162290916 cites W2055237453 @default.
- W2162290916 cites W2055553707 @default.
- W2162290916 cites W2060155592 @default.
- W2162290916 cites W2064861163 @default.
- W2162290916 cites W2074029111 @default.
- W2162290916 cites W2074798818 @default.
- W2162290916 cites W2077252523 @default.
- W2162290916 cites W2078583788 @default.
- W2162290916 cites W2086799994 @default.
- W2162290916 cites W2089415609 @default.
- W2162290916 cites W2089481117 @default.
- W2162290916 cites W2091503140 @default.
- W2162290916 cites W2097743364 @default.
- W2162290916 cites W2099907183 @default.
- W2162290916 cites W2104496514 @default.
- W2162290916 cites W2110994467 @default.
- W2162290916 cites W2112444085 @default.
- W2162290916 cites W2112902699 @default.
- W2162290916 cites W2116835317 @default.
- W2162290916 cites W2117121254 @default.
- W2162290916 cites W2122230573 @default.
- W2162290916 cites W2125180026 @default.
- W2162290916 cites W2125700595 @default.
- W2162290916 cites W2126775400 @default.
- W2162290916 cites W2128609874 @default.
- W2162290916 cites W2130193649 @default.
- W2162290916 cites W2132582013 @default.
- W2162290916 cites W2134555277 @default.
- W2162290916 cites W2135832165 @default.
- W2162290916 cites W2136691282 @default.
- W2162290916 cites W2137815533 @default.
- W2162290916 cites W2143086385 @default.
- W2162290916 cites W2143091712 @default.
- W2162290916 cites W2144998962 @default.
- W2162290916 cites W2146152969 @default.
- W2162290916 cites W2147152088 @default.
- W2162290916 cites W2147530983 @default.
- W2162290916 cites W2148118486 @default.
- W2162290916 cites W2149213466 @default.
- W2162290916 cites W2149563447 @default.
- W2162290916 cites W2153782423 @default.
- W2162290916 cites W2155235554 @default.
- W2162290916 cites W2155236768 @default.
- W2162290916 cites W2155645460 @default.
- W2162290916 cites W2156874253 @default.
- W2162290916 cites W2158920055 @default.
- W2162290916 cites W2159615538 @default.
- W2162290916 cites W2161663274 @default.
- W2162290916 cites W2162117160 @default.
- W2162290916 cites W2163327652 @default.
- W2162290916 cites W2165836069 @default.
- W2162290916 cites W2167684047 @default.
- W2162290916 cites W2169556367 @default.