Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162291125> ?p ?o ?g. }
- W2162291125 endingPage "366" @default.
- W2162291125 startingPage "360" @default.
- W2162291125 abstract "Neuropeptide S (NPS) is a neurotransmitter/neuromodulator that has been identified as the natural ligand of G protein-coupled receptors termed NPS receptors (NPSRs). The NPS-NPSR system is involved in the control of numerous centrally-mediated behaviours, including anxiety. As several classical transmitters play a role in fear/anxiety, we here investigated the regulation by NPS of the exocytotic release of 5-hydroxytryptamine (5-HT) and glycine in nerve terminals isolated from mouse frontal/prefrontal cortex and amygdala. Synaptosomes, prelabelled with the tritiated neurotransmitters, were depolarized in superfusion with 12-15 mM KCl and exposed to varying concentrations of NPS. The evoked release of [(3)H]5-HT in frontal/prefrontal cortex was potently inhibited by NPS (maximal effect about 25% at 0.1 nM). Differently, the neuropeptide exhibited higher efficacy but much lower potency in amygdala (maximal effect about 40% at 1 μM). NPS was an extremely potent inhibitor of the K(+)-evoked release of [(3)H]glycine in frontal/prefrontal nerve endings (maximal effect about 25% at 1 pM). All the inhibitory effects observed were counteracted by the NPSR antagonist SHA 68, indicating that the neuropeptide acted at NPSRs. In conclusion, NPS can inhibit the exocytosis of 5-HT and of glycine through the activation of presynaptic NPSRs situated on serotonergic and glycinergic terminals in areas involved in fear/anxiety behaviours. The possibility exists that the NPSRs in frontal/prefrontal cortex are high-affinity receptors involved in non-synaptic transmission, whereas the NPSRs on amygdala serotonergic terminals are low-affinity receptors involved in axo-axonic synaptic communication." @default.
- W2162291125 created "2016-06-24" @default.
- W2162291125 creator A5007320925 @default.
- W2162291125 creator A5019238642 @default.
- W2162291125 creator A5020043805 @default.
- W2162291125 creator A5037065292 @default.
- W2162291125 creator A5040887321 @default.
- W2162291125 creator A5090301094 @default.
- W2162291125 date "2013-03-01" @default.
- W2162291125 modified "2023-09-27" @default.
- W2162291125 title "Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor" @default.
- W2162291125 cites W1547568333 @default.
- W2162291125 cites W1554259536 @default.
- W2162291125 cites W1583921757 @default.
- W2162291125 cites W1603958335 @default.
- W2162291125 cites W1665550861 @default.
- W2162291125 cites W1675927101 @default.
- W2162291125 cites W1786092055 @default.
- W2162291125 cites W1974156538 @default.
- W2162291125 cites W1979367793 @default.
- W2162291125 cites W1979784733 @default.
- W2162291125 cites W1981111905 @default.
- W2162291125 cites W1982295297 @default.
- W2162291125 cites W1982807202 @default.
- W2162291125 cites W1982958438 @default.
- W2162291125 cites W1985993367 @default.
- W2162291125 cites W1986601294 @default.
- W2162291125 cites W1990189870 @default.
- W2162291125 cites W1997631508 @default.
- W2162291125 cites W2016336988 @default.
- W2162291125 cites W2019347876 @default.
- W2162291125 cites W2020763825 @default.
- W2162291125 cites W2023443471 @default.
- W2162291125 cites W2024531451 @default.
- W2162291125 cites W2024996846 @default.
- W2162291125 cites W2027067524 @default.
- W2162291125 cites W2028020939 @default.
- W2162291125 cites W2028884770 @default.
- W2162291125 cites W2031598294 @default.
- W2162291125 cites W2034200902 @default.
- W2162291125 cites W2038704879 @default.
- W2162291125 cites W2041721232 @default.
- W2162291125 cites W2042030103 @default.
- W2162291125 cites W2046058158 @default.
- W2162291125 cites W2046204510 @default.
- W2162291125 cites W2058838975 @default.
- W2162291125 cites W2060890290 @default.
- W2162291125 cites W2063641313 @default.
- W2162291125 cites W2068813862 @default.
- W2162291125 cites W2075370186 @default.
- W2162291125 cites W2076290487 @default.
- W2162291125 cites W2081678712 @default.
- W2162291125 cites W2082369948 @default.
- W2162291125 cites W2084873146 @default.
- W2162291125 cites W2085332671 @default.
- W2162291125 cites W2088157575 @default.
- W2162291125 cites W2089891490 @default.
- W2162291125 cites W2090951839 @default.
- W2162291125 cites W2091809123 @default.
- W2162291125 cites W2093270220 @default.
- W2162291125 cites W2103880802 @default.
- W2162291125 cites W2104239339 @default.
- W2162291125 cites W2110654827 @default.
- W2162291125 cites W2111178305 @default.
- W2162291125 cites W2116777802 @default.
- W2162291125 cites W2120251526 @default.
- W2162291125 cites W2121361277 @default.
- W2162291125 cites W2127549277 @default.
- W2162291125 cites W2129914802 @default.
- W2162291125 cites W2138522158 @default.
- W2162291125 cites W2138980669 @default.
- W2162291125 cites W2142324040 @default.
- W2162291125 cites W2145233873 @default.
- W2162291125 cites W2146437126 @default.
- W2162291125 cites W2156842294 @default.
- W2162291125 cites W2158137297 @default.
- W2162291125 cites W2158197796 @default.
- W2162291125 cites W2168792587 @default.
- W2162291125 cites W2189098641 @default.
- W2162291125 cites W3166732914 @default.
- W2162291125 cites W4362211302 @default.
- W2162291125 cites W69341822 @default.
- W2162291125 cites W2537693929 @default.
- W2162291125 doi "https://doi.org/10.1016/j.neuint.2013.02.003" @default.
- W2162291125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23411412" @default.
- W2162291125 hasPublicationYear "2013" @default.
- W2162291125 type Work @default.
- W2162291125 sameAs 2162291125 @default.
- W2162291125 citedByCount "6" @default.
- W2162291125 countsByYear W21622911252013 @default.
- W2162291125 countsByYear W21622911252015 @default.
- W2162291125 countsByYear W21622911252018 @default.
- W2162291125 countsByYear W21622911252021 @default.
- W2162291125 countsByYear W21622911252022 @default.
- W2162291125 crossrefType "journal-article" @default.
- W2162291125 hasAuthorship W2162291125A5007320925 @default.
- W2162291125 hasAuthorship W2162291125A5019238642 @default.
- W2162291125 hasAuthorship W2162291125A5020043805 @default.