Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162312089> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2162312089 abstract "We have previously shown that inhibition of the proinflammatory cytokine tumor necrosis factor- (TNF)-alpha exacerbates the inflammatory process of EIU. To further examine this paradoxic phenomenon, we investigated here the effect on EIU of VIP, a neuropeptide that inbibits TNF-alpha production.VIP was injected concurrently with endotoxin at doses that induce EIU or lethality in mice. Severity of EIU was measured by counting infiltrating cells in eye sections, at 1 or 5 days post endotoxin injection. Survival of mice was monitored periodically, while serum levels of TNF-alpha, interleukin-(IL)-1beta and IL-10 were determined by caputure ELISA.Treatment with VIP exacerbated EIU but provided partial protection from the lethal endotoxin effect. VIP treatment also reduced serum levels of TNF-alpha and IL-1beta, but increased levels of IL-10.This study further established the paradoxical observation that EIU is exacerbated by lowering the levels of circulating pro-inflammatory cytokines, in particular TNF-alpha." @default.
- W2162312089 created "2016-06-24" @default.
- W2162312089 creator A5036120450 @default.
- W2162312089 creator A5050309376 @default.
- W2162312089 creator A5056582438 @default.
- W2162312089 date "2000-01-01" @default.
- W2162312089 modified "2023-09-24" @default.
- W2162312089 title "Vasoactive Intestinal Peptide (VIP) exacerbates Endotoxin-induced Uveitis (EIU) in mice" @default.
- W2162312089 cites W1964065006 @default.
- W2162312089 cites W2029974988 @default.
- W2162312089 cites W2066671938 @default.
- W2162312089 cites W2095308349 @default.
- W2162312089 doi "https://doi.org/10.1076/ceyr.21.6.913.6986" @default.
- W2162312089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11262614" @default.
- W2162312089 hasPublicationYear "2000" @default.
- W2162312089 type Work @default.
- W2162312089 sameAs 2162312089 @default.
- W2162312089 citedByCount "9" @default.
- W2162312089 countsByYear W21623120892012 @default.
- W2162312089 countsByYear W21623120892017 @default.
- W2162312089 crossrefType "journal-article" @default.
- W2162312089 hasAuthorship W2162312089A5036120450 @default.
- W2162312089 hasAuthorship W2162312089A5050309376 @default.
- W2162312089 hasAuthorship W2162312089A5056582438 @default.
- W2162312089 hasConcept C118303440 @default.
- W2162312089 hasConcept C126322002 @default.
- W2162312089 hasConcept C134018914 @default.
- W2162312089 hasConcept C164027704 @default.
- W2162312089 hasConcept C170493617 @default.
- W2162312089 hasConcept C17991360 @default.
- W2162312089 hasConcept C203014093 @default.
- W2162312089 hasConcept C2776194053 @default.
- W2162312089 hasConcept C2776914184 @default.
- W2162312089 hasConcept C2778690821 @default.
- W2162312089 hasConcept C71924100 @default.
- W2162312089 hasConcept C74172505 @default.
- W2162312089 hasConcept C8330315 @default.
- W2162312089 hasConceptScore W2162312089C118303440 @default.
- W2162312089 hasConceptScore W2162312089C126322002 @default.
- W2162312089 hasConceptScore W2162312089C134018914 @default.
- W2162312089 hasConceptScore W2162312089C164027704 @default.
- W2162312089 hasConceptScore W2162312089C170493617 @default.
- W2162312089 hasConceptScore W2162312089C17991360 @default.
- W2162312089 hasConceptScore W2162312089C203014093 @default.
- W2162312089 hasConceptScore W2162312089C2776194053 @default.
- W2162312089 hasConceptScore W2162312089C2776914184 @default.
- W2162312089 hasConceptScore W2162312089C2778690821 @default.
- W2162312089 hasConceptScore W2162312089C71924100 @default.
- W2162312089 hasConceptScore W2162312089C74172505 @default.
- W2162312089 hasConceptScore W2162312089C8330315 @default.
- W2162312089 hasLocation W21623120891 @default.
- W2162312089 hasLocation W21623120892 @default.
- W2162312089 hasOpenAccess W2162312089 @default.
- W2162312089 hasPrimaryLocation W21623120891 @default.
- W2162312089 hasRelatedWork W129733656 @default.
- W2162312089 hasRelatedWork W155677955 @default.
- W2162312089 hasRelatedWork W1972752943 @default.
- W2162312089 hasRelatedWork W1983115674 @default.
- W2162312089 hasRelatedWork W1985231739 @default.
- W2162312089 hasRelatedWork W1999086132 @default.
- W2162312089 hasRelatedWork W2015723255 @default.
- W2162312089 hasRelatedWork W2031563447 @default.
- W2162312089 hasRelatedWork W2044718664 @default.
- W2162312089 hasRelatedWork W2069855822 @default.
- W2162312089 hasRelatedWork W2076066061 @default.
- W2162312089 hasRelatedWork W2078261443 @default.
- W2162312089 hasRelatedWork W2104541229 @default.
- W2162312089 hasRelatedWork W2105070448 @default.
- W2162312089 hasRelatedWork W2111970438 @default.
- W2162312089 hasRelatedWork W2319936132 @default.
- W2162312089 hasRelatedWork W2580540891 @default.
- W2162312089 hasRelatedWork W2806613511 @default.
- W2162312089 hasRelatedWork W3148016601 @default.
- W2162312089 hasRelatedWork W1975568677 @default.
- W2162312089 isParatext "false" @default.
- W2162312089 isRetracted "false" @default.
- W2162312089 magId "2162312089" @default.
- W2162312089 workType "article" @default.