FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162321373> ?p ?o ?g. }

• W2162321373 endingPage "341" @default.
• W2162321373 startingPage "334" @default.
• W2162321373 abstract "Self-renewing tissues have a differentiation hierarchy such that the stem cells are the only permanent residents of the tissue, and it is in these cells that most cancerous mutations arise. The progeny of the stem cells either remain stem cells or enter a transient proliferating cell population that differentiates to produce the functional cells of the tissue. The reason that this differentiation hierarchy exists has not been established. We show here that alternative hierarchies, in which there would be no stem cells, are feasible and biologically plausible. We show that current evidence from somatic mutation frequencies at both transgenic and endogenous loci implicates cell division in the origin of most somatic mutations. We suggest, therefore, that the existence of stem cells is an evolutionary consequence of a selective pressure to avoid cancer by reducing the number of somatic mutations. The stem cell hierarchy reduces the number of cell divisions of those cells that reside permanently in the tissue, which reduces the number of somatic mutations and thus minimizes the cancer rate. In the small intestine, the existence of stem cells reduces the mutant frequency in the stem cells by about one order of magnitude. Since two or more mutations are required to transform a cell, the protective effect may be 100-fold or more. Similar factors may be expected in other tissues." @default.
• W2162321373 created "2016-06-24" @default.
• W2162321373 creator A5013008257 @default.
• W2162321373 creator A5021862504 @default.
• W2162321373 creator A5041207316 @default.
• W2162321373 creator A5066463619 @default.
• W2162321373 creator A5086021560 @default.
• W2162321373 date "1996-01-01" @default.
• W2162321373 modified "2023-09-27" @default.
• W2162321373 title "System issues: Why do stem cells exist?" @default.
• W2162321373 cites W1578610977 @default.
• W2162321373 cites W1845735905 @default.
• W2162321373 cites W1894632965 @default.
• W2162321373 cites W1931753277 @default.
• W2162321373 cites W1969589951 @default.
• W2162321373 cites W1976856900 @default.
• W2162321373 cites W1981490989 @default.
• W2162321373 cites W1983465251 @default.
• W2162321373 cites W1984834801 @default.
• W2162321373 cites W1989229428 @default.
• W2162321373 cites W2000023996 @default.
• W2162321373 cites W2001258296 @default.
• W2162321373 cites W2002547558 @default.
• W2162321373 cites W2021207588 @default.
• W2162321373 cites W2023183006 @default.
• W2162321373 cites W2023309034 @default.
• W2162321373 cites W2024716938 @default.
• W2162321373 cites W2052283525 @default.
• W2162321373 cites W2057278856 @default.
• W2162321373 cites W2062090889 @default.
• W2162321373 cites W2067951632 @default.
• W2162321373 cites W2090608877 @default.
• W2162321373 cites W2094536764 @default.
• W2162321373 cites W2131856161 @default.
• W2162321373 cites W2148459495 @default.
• W2162321373 cites W2163927458 @default.
• W2162321373 doi "https://doi.org/10.1002/(sici)1098-2280(1996)28:4<334::aid-em6>3.0.co;2-b" @default.
• W2162321373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8991061" @default.
• W2162321373 hasPublicationYear "1996" @default.
• W2162321373 type Work @default.
• W2162321373 sameAs 2162321373 @default.
• W2162321373 citedByCount "22" @default.
• W2162321373 crossrefType "journal-article" @default.
• W2162321373 hasAuthorship W2162321373A5013008257 @default.
• W2162321373 hasAuthorship W2162321373A5021862504 @default.
• W2162321373 hasAuthorship W2162321373A5041207316 @default.
• W2162321373 hasAuthorship W2162321373A5066463619 @default.
• W2162321373 hasAuthorship W2162321373A5086021560 @default.
• W2162321373 hasConcept C104317684 @default.
• W2162321373 hasConcept C134305767 @default.
• W2162321373 hasConcept C14218858 @default.
• W2162321373 hasConcept C144024400 @default.
• W2162321373 hasConcept C148738053 @default.
• W2162321373 hasConcept C1491633281 @default.
• W2162321373 hasConcept C149923435 @default.
• W2162321373 hasConcept C201750760 @default.
• W2162321373 hasConcept C2022786 @default.
• W2162321373 hasConcept C20875687 @default.
• W2162321373 hasConcept C28328180 @default.
• W2162321373 hasConcept C2908647359 @default.
• W2162321373 hasConcept C501734568 @default.
• W2162321373 hasConcept C54355233 @default.
• W2162321373 hasConcept C55427017 @default.
• W2162321373 hasConcept C85813293 @default.
• W2162321373 hasConcept C86803240 @default.
• W2162321373 hasConcept C95444343 @default.
• W2162321373 hasConceptScore W2162321373C104317684 @default.
• W2162321373 hasConceptScore W2162321373C134305767 @default.
• W2162321373 hasConceptScore W2162321373C14218858 @default.
• W2162321373 hasConceptScore W2162321373C144024400 @default.
• W2162321373 hasConceptScore W2162321373C148738053 @default.
• W2162321373 hasConceptScore W2162321373C1491633281 @default.
• W2162321373 hasConceptScore W2162321373C149923435 @default.
• W2162321373 hasConceptScore W2162321373C201750760 @default.
• W2162321373 hasConceptScore W2162321373C2022786 @default.
• W2162321373 hasConceptScore W2162321373C20875687 @default.
• W2162321373 hasConceptScore W2162321373C28328180 @default.
• W2162321373 hasConceptScore W2162321373C2908647359 @default.
• W2162321373 hasConceptScore W2162321373C501734568 @default.
• W2162321373 hasConceptScore W2162321373C54355233 @default.
• W2162321373 hasConceptScore W2162321373C55427017 @default.
• W2162321373 hasConceptScore W2162321373C85813293 @default.
• W2162321373 hasConceptScore W2162321373C86803240 @default.
• W2162321373 hasConceptScore W2162321373C95444343 @default.
• W2162321373 hasIssue "4" @default.
• W2162321373 hasLocation W21623213731 @default.
• W2162321373 hasLocation W21623213732 @default.
• W2162321373 hasOpenAccess W2162321373 @default.
• W2162321373 hasPrimaryLocation W21623213731 @default.
• W2162321373 hasRelatedWork W1645378787 @default.
• W2162321373 hasRelatedWork W2060738125 @default.
• W2162321373 hasRelatedWork W2162321373 @default.
• W2162321373 hasRelatedWork W2308062253 @default.
• W2162321373 hasRelatedWork W2412306067 @default.
• W2162321373 hasRelatedWork W2942732239 @default.
• W2162321373 hasRelatedWork W3009968739 @default.
• W2162321373 hasRelatedWork W3036674976 @default.
• W2162321373 hasRelatedWork W4242129305 @default.

• next