Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162361792> ?p ?o ?g. }
- W2162361792 endingPage "307" @default.
- W2162361792 startingPage "277" @default.
- W2162361792 abstract "A selective kappa-opioid receptor (KOR) agonist might act as a powerful analgesic without the side effects of micro-opioid receptor-selective drugs such as morphine. The eight classes of known KOR agonists have different chemical structures, making it difficult to construct a pharmacophore model that takes them all into account. Here, we summarize previous efforts to identify the pharmacophore for kappa-opioid agonists and propose a new three-dimensional pharmacophore model that encompasses the kappa-activities of all classes. This utilizes conformational sampling of agonists by high-temperature molecular dynamics and pharmacophore extraction through a series of molecular superpositions." @default.
- W2162361792 created "2016-06-24" @default.
- W2162361792 creator A5004389476 @default.
- W2162361792 creator A5033231414 @default.
- W2162361792 date "2010-01-01" @default.
- W2162361792 modified "2023-10-02" @default.
- W2162361792 title "3D-Pharmacophore Identification for κ-Opioid Agonists Using Ligand-Based Drug-Design Techniques" @default.
- W2162361792 cites W1498679715 @default.
- W2162361792 cites W1574404959 @default.
- W2162361792 cites W1966556269 @default.
- W2162361792 cites W1977487524 @default.
- W2162361792 cites W1988767853 @default.
- W2162361792 cites W1989193865 @default.
- W2162361792 cites W1990469598 @default.
- W2162361792 cites W1993136139 @default.
- W2162361792 cites W1993659014 @default.
- W2162361792 cites W1999307382 @default.
- W2162361792 cites W1999919337 @default.
- W2162361792 cites W2005643237 @default.
- W2162361792 cites W2019294007 @default.
- W2162361792 cites W2021750784 @default.
- W2162361792 cites W2022478977 @default.
- W2162361792 cites W2025268117 @default.
- W2162361792 cites W2026169600 @default.
- W2162361792 cites W2027694520 @default.
- W2162361792 cites W2028176567 @default.
- W2162361792 cites W2031581690 @default.
- W2162361792 cites W2032681246 @default.
- W2162361792 cites W2033640369 @default.
- W2162361792 cites W2034700992 @default.
- W2162361792 cites W2034934367 @default.
- W2162361792 cites W2035379299 @default.
- W2162361792 cites W2040043777 @default.
- W2162361792 cites W2040054958 @default.
- W2162361792 cites W2042185302 @default.
- W2162361792 cites W2044742590 @default.
- W2162361792 cites W2053629407 @default.
- W2162361792 cites W2054244091 @default.
- W2162361792 cites W2055698172 @default.
- W2162361792 cites W2057491831 @default.
- W2162361792 cites W2058107171 @default.
- W2162361792 cites W2059512977 @default.
- W2162361792 cites W2060620819 @default.
- W2162361792 cites W2060985440 @default.
- W2162361792 cites W2061604677 @default.
- W2162361792 cites W2063287670 @default.
- W2162361792 cites W2064284932 @default.
- W2162361792 cites W2065331570 @default.
- W2162361792 cites W2068220609 @default.
- W2162361792 cites W2071253111 @default.
- W2162361792 cites W2071579644 @default.
- W2162361792 cites W2073548424 @default.
- W2162361792 cites W2074599713 @default.
- W2162361792 cites W2074912730 @default.
- W2162361792 cites W2077491137 @default.
- W2162361792 cites W2081340712 @default.
- W2162361792 cites W2082487625 @default.
- W2162361792 cites W2085536605 @default.
- W2162361792 cites W2087132242 @default.
- W2162361792 cites W2087848507 @default.
- W2162361792 cites W2090425390 @default.
- W2162361792 cites W2107998520 @default.
- W2162361792 cites W2111738864 @default.
- W2162361792 cites W2121887620 @default.
- W2162361792 cites W2122480275 @default.
- W2162361792 cites W2131302772 @default.
- W2162361792 cites W2158513208 @default.
- W2162361792 cites W2166153441 @default.
- W2162361792 cites W2168293844 @default.
- W2162361792 cites W2170826276 @default.
- W2162361792 cites W2170868211 @default.
- W2162361792 cites W2331919111 @default.
- W2162361792 cites W2949427142 @default.
- W2162361792 cites W2950070511 @default.
- W2162361792 cites W2952272667 @default.
- W2162361792 doi "https://doi.org/10.1007/128_2010_84" @default.
- W2162361792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21630511" @default.
- W2162361792 hasPublicationYear "2010" @default.
- W2162361792 type Work @default.
- W2162361792 sameAs 2162361792 @default.
- W2162361792 citedByCount "20" @default.
- W2162361792 countsByYear W21623617922012 @default.
- W2162361792 countsByYear W21623617922014 @default.
- W2162361792 countsByYear W21623617922015 @default.
- W2162361792 countsByYear W21623617922017 @default.
- W2162361792 countsByYear W21623617922020 @default.
- W2162361792 countsByYear W21623617922022 @default.
- W2162361792 countsByYear W21623617922023 @default.
- W2162361792 crossrefType "book-chapter" @default.
- W2162361792 hasAuthorship W2162361792A5004389476 @default.
- W2162361792 hasAuthorship W2162361792A5033231414 @default.
- W2162361792 hasConcept C170493617 @default.
- W2162361792 hasConcept C184389661 @default.
- W2162361792 hasConcept C185592680 @default.
- W2162361792 hasConcept C21951064 @default.
- W2162361792 hasConcept C2778938600 @default.
- W2162361792 hasConcept C2779886867 @default.
- W2162361792 hasConcept C2781063702 @default.