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- W2162362541 abstract "The influence of short term, high dose glucocorticoids on pancreatic polypeptide (PP), GH, and PRL responses to insulin-induced hypoglycemia was studied in normal young men. Subjects underwent insulin tolerance tests before (ITTb) and on the fifth day (ITT5) of treatment with prednisone (25 mg orally twice daily) and again 2 (ITT7) and 5 (ITT10) days after termination of prednisone therapy. Eleven subjects completed ITTh, ITT7) and ITT10. Five of these underwent ITT5. Despite the more pronounced hypoglycemia associated with the higher insulin dose used during prednisone treatment, PP responses were significantly diminished. Basal PP was reduced from 92.7 ± 13 to 38.6 ± 5.7 pg/ml (P < 0.05) at the time of ITT5 and returned to pretreatment values at the time of ITT7. The peak pretreatment PP concentration of 1328 ± 203 pg/ml was reduced to 584 ± 118 (P < 0.05) during ITT5, and after discontinuation of prednisone returned progressively to pretreatment values. A more marked suppression was evident from compar..." @default.
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- W2162362541 date "1980-02-01" @default.
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- W2162362541 title "Glucocorticoid Suppression of Pancreatic and Pituitary Hormones: Pancreatic Polypeptide, Growth Hormone, and Prolactin*" @default.
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- W2162362541 doi "https://doi.org/10.1210/jcem-50-2-298" @default.
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