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• W2162364181 abstract "Summary P seudomonas aeruginosa can sense and respond to a myriad of environmental signals and utilizes a system of small molecules to communicate through intercellular signaling. The small molecule 2‐heptyl‐3‐hydroxy‐4‐quinolone ( P seudomonas Q uinolone S ignal [ PQS ]) is one of these signals and its synthesis is important for virulence. Previously, we identified an R pi R ‐type transcriptional regulator, Q ap R , that positively affects PQS production by repressing the qap R operon. An in‐frame deletion of this regulator caused P . aeruginosa to produce a greatly reduced concentration of PQS . Here, we report that Q ap R translation is linked to the downstream gene PA 5507 . We found that introduction of a premature stop codon within qap R eliminates transcriptional autorepression of the qap R operon as expected but has no effect on PQS concentration. This was investigated with a series of lac Z reporter fusions which showed that translation of Q ap R must terminate at, or close to, the native qap R stop codon in order for translation of PA 5507 to occur. Also, it was shown that truncation of the 5′ end of the qap R transcript permitted PA 5507 translation without translation of Q ap R . Our findings led us to conclude that PA 5507 transcription and translation are both tightly controlled by Q ap R and this control is important for PQS homeostasis." @default.
• W2162364181 created "2016-06-24" @default.
• W2162364181 creator A5016727360 @default.
• W2162364181 creator A5047741781 @default.
• W2162364181 creator A5048393189 @default.
• W2162364181 date "2015-03-06" @default.
• W2162364181 modified "2023-10-03" @default.
• W2162364181 title "Post-transcriptional regulation of gene PA5507 controls<i>P</i><i>seudomonas</i>quinolone signal concentration in<i>P</i><i>. aeruginosa</i>" @default.
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• W2162364181 doi "https://doi.org/10.1111/mmi.12963" @default.
• W2162364181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4419738" @default.
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• W2162364181 hasPublicationYear "2015" @default.
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