Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162366162> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2162366162 endingPage "188" @default.
- W2162366162 startingPage "184" @default.
- W2162366162 abstract "Proliferative endosteal lesions were observed in metaphysis and diaphysis of femur and sternebra of Wistar (CRL:[WI]BR) rats administered 3 chemically-distinct anticancer compounds with dissimilar mechanisms of action: trimetrexate glucuronate, an antifolate; pentostatin, an adenosine deaminase inhibitor; and CI-980, a mitotic inhibitor. Islands of woven bone, often circumscribed by conspicuous myelostromal proliferation, were seen on Days 8-28 in rats given trimetrexate glucuronate daily by gavage, and on Day 4 but not Day 29 in rats given a single intravenous dose of pentostatin. Intravenous administration of CI-980 for 1 or 5 days resulted in marrow necrosis, marked centripetal new bone formation, and myelostromal proliferation on Days 4 and 8, respectively. These lesions were not present at the termination of these latter studies (Days 29 and 35, respectively). In conclusion, anticancer compounds induced local bone marrow injury and the release of local inflammatory mediators which may have provided the stimulus for bone formation and myelostromal proliferation." @default.
- W2162366162 created "2016-06-24" @default.
- W2162366162 creator A5009653842 @default.
- W2162366162 creator A5030994342 @default.
- W2162366162 creator A5040752825 @default.
- W2162366162 creator A5062022785 @default.
- W2162366162 creator A5086865127 @default.
- W2162366162 date "1991-02-01" @default.
- W2162366162 modified "2023-09-26" @default.
- W2162366162 title "Proliferative Bone Lesions in Rats Given Anticancer Compounds" @default.
- W2162366162 cites W2009877560 @default.
- W2162366162 cites W2021094579 @default.
- W2162366162 cites W2030951215 @default.
- W2162366162 cites W2049787159 @default.
- W2162366162 cites W2068537168 @default.
- W2162366162 cites W2086781664 @default.
- W2162366162 cites W2130971414 @default.
- W2162366162 cites W2162062204 @default.
- W2162366162 cites W4251818076 @default.
- W2162366162 doi "https://doi.org/10.1177/019262339101900214" @default.
- W2162366162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1837612" @default.
- W2162366162 hasPublicationYear "1991" @default.
- W2162366162 type Work @default.
- W2162366162 sameAs 2162366162 @default.
- W2162366162 citedByCount "13" @default.
- W2162366162 countsByYear W21623661622012 @default.
- W2162366162 countsByYear W21623661622016 @default.
- W2162366162 countsByYear W21623661622017 @default.
- W2162366162 countsByYear W21623661622018 @default.
- W2162366162 countsByYear W21623661622019 @default.
- W2162366162 countsByYear W21623661622022 @default.
- W2162366162 crossrefType "journal-article" @default.
- W2162366162 hasAuthorship W2162366162A5009653842 @default.
- W2162366162 hasAuthorship W2162366162A5030994342 @default.
- W2162366162 hasAuthorship W2162366162A5040752825 @default.
- W2162366162 hasAuthorship W2162366162A5062022785 @default.
- W2162366162 hasAuthorship W2162366162A5086865127 @default.
- W2162366162 hasConcept C126322002 @default.
- W2162366162 hasConcept C134018914 @default.
- W2162366162 hasConcept C142724271 @default.
- W2162366162 hasConcept C185592680 @default.
- W2162366162 hasConcept C2775952470 @default.
- W2162366162 hasConcept C2776991684 @default.
- W2162366162 hasConcept C2780007613 @default.
- W2162366162 hasConcept C2910678351 @default.
- W2162366162 hasConcept C34628245 @default.
- W2162366162 hasConcept C55493867 @default.
- W2162366162 hasConcept C71924100 @default.
- W2162366162 hasConcept C98274493 @default.
- W2162366162 hasConceptScore W2162366162C126322002 @default.
- W2162366162 hasConceptScore W2162366162C134018914 @default.
- W2162366162 hasConceptScore W2162366162C142724271 @default.
- W2162366162 hasConceptScore W2162366162C185592680 @default.
- W2162366162 hasConceptScore W2162366162C2775952470 @default.
- W2162366162 hasConceptScore W2162366162C2776991684 @default.
- W2162366162 hasConceptScore W2162366162C2780007613 @default.
- W2162366162 hasConceptScore W2162366162C2910678351 @default.
- W2162366162 hasConceptScore W2162366162C34628245 @default.
- W2162366162 hasConceptScore W2162366162C55493867 @default.
- W2162366162 hasConceptScore W2162366162C71924100 @default.
- W2162366162 hasConceptScore W2162366162C98274493 @default.
- W2162366162 hasIssue "2" @default.
- W2162366162 hasLocation W21623661621 @default.
- W2162366162 hasLocation W21623661622 @default.
- W2162366162 hasOpenAccess W2162366162 @default.
- W2162366162 hasPrimaryLocation W21623661621 @default.
- W2162366162 hasRelatedWork W1966504330 @default.
- W2162366162 hasRelatedWork W1966775726 @default.
- W2162366162 hasRelatedWork W1979139803 @default.
- W2162366162 hasRelatedWork W2030889776 @default.
- W2162366162 hasRelatedWork W2037631372 @default.
- W2162366162 hasRelatedWork W2040058909 @default.
- W2162366162 hasRelatedWork W2132898409 @default.
- W2162366162 hasRelatedWork W2748952813 @default.
- W2162366162 hasRelatedWork W2899084033 @default.
- W2162366162 hasRelatedWork W4249176446 @default.
- W2162366162 hasVolume "19" @default.
- W2162366162 isParatext "false" @default.
- W2162366162 isRetracted "false" @default.
- W2162366162 magId "2162366162" @default.
- W2162366162 workType "article" @default.