Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162377175> ?p ?o ?g. }
- W2162377175 endingPage "11" @default.
- W2162377175 startingPage "1" @default.
- W2162377175 abstract "Vascular endothelium plays a critical role in the control of blood flow by producing vasoactive factors to regulate vascular tone. Ion channels, in particular, K + channels and Ca 2+ -permeable channels in endothelial cells, are essential to the production and function of endothelium-derived vasoactive factors. Impairment of coronary endothelial function occurs in open heart surgery that may result in reduction of coronary blood flow and thus in an inadequate myocardial perfusion. Hyperkalemic exposure and concurrent ischemia-reperfusion during cardioplegic intervention compromise NO and EDHF-mediated function and the impairment involves alterations of K + channels, that is,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mtext>K</mml:mtext></mml:mrow><mml:mrow><mml:mtext>ATP</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mtext>K</mml:mtext></mml:mrow><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>, and Ca 2+ -permeable TRP channels in endothelial cells. Pharmacological modulation of these channels during ischemia-reperfusion and hyperkalemic exposure show promising results on the preservation of NO and EDHF-mediated endothelial function, which suggests the potential of targeting endothelial K + and TRP channels for myocardial protection during cardiac surgery." @default.
- W2162377175 created "2016-06-24" @default.
- W2162377175 creator A5005922314 @default.
- W2162377175 creator A5017713517 @default.
- W2162377175 creator A5036005135 @default.
- W2162377175 creator A5064231427 @default.
- W2162377175 date "2014-01-01" @default.
- W2162377175 modified "2023-10-14" @default.
- W2162377175 title "Protection of Coronary Endothelial Function during Cardiac Surgery: Potential of Targeting Endothelial Ion Channels in Cardioprotection" @default.
- W2162377175 cites W1507386113 @default.
- W2162377175 cites W1536615603 @default.
- W2162377175 cites W1546802604 @default.
- W2162377175 cites W1582230631 @default.
- W2162377175 cites W1834643162 @default.
- W2162377175 cites W1967122432 @default.
- W2162377175 cites W1967558670 @default.
- W2162377175 cites W1968135647 @default.
- W2162377175 cites W1970151737 @default.
- W2162377175 cites W1970957108 @default.
- W2162377175 cites W1974049663 @default.
- W2162377175 cites W1976461271 @default.
- W2162377175 cites W1976938093 @default.
- W2162377175 cites W1979414223 @default.
- W2162377175 cites W1982034657 @default.
- W2162377175 cites W1982363639 @default.
- W2162377175 cites W1982580263 @default.
- W2162377175 cites W1983188578 @default.
- W2162377175 cites W1986407102 @default.
- W2162377175 cites W1987713060 @default.
- W2162377175 cites W1987891633 @default.
- W2162377175 cites W1988160513 @default.
- W2162377175 cites W1993825065 @default.
- W2162377175 cites W1994400891 @default.
- W2162377175 cites W1995457549 @default.
- W2162377175 cites W1996050304 @default.
- W2162377175 cites W2000209683 @default.
- W2162377175 cites W2001079692 @default.
- W2162377175 cites W2002330139 @default.
- W2162377175 cites W2005285935 @default.
- W2162377175 cites W2009213735 @default.
- W2162377175 cites W2009442111 @default.
- W2162377175 cites W2009625374 @default.
- W2162377175 cites W2010897667 @default.
- W2162377175 cites W2012012271 @default.
- W2162377175 cites W2015095580 @default.
- W2162377175 cites W2020460437 @default.
- W2162377175 cites W2021739695 @default.
- W2162377175 cites W2031836453 @default.
- W2162377175 cites W2036385803 @default.
- W2162377175 cites W2036923000 @default.
- W2162377175 cites W2037000160 @default.
- W2162377175 cites W2037550336 @default.
- W2162377175 cites W2038237785 @default.
- W2162377175 cites W2040552632 @default.
- W2162377175 cites W2043072729 @default.
- W2162377175 cites W2043160737 @default.
- W2162377175 cites W2043453258 @default.
- W2162377175 cites W2045387175 @default.
- W2162377175 cites W2048492290 @default.
- W2162377175 cites W2053095154 @default.
- W2162377175 cites W2053627692 @default.
- W2162377175 cites W2053752992 @default.
- W2162377175 cites W2056904212 @default.
- W2162377175 cites W2062050978 @default.
- W2162377175 cites W2062165989 @default.
- W2162377175 cites W2065906335 @default.
- W2162377175 cites W2066190048 @default.
- W2162377175 cites W2069358667 @default.
- W2162377175 cites W2069544003 @default.
- W2162377175 cites W2073338904 @default.
- W2162377175 cites W2074117584 @default.
- W2162377175 cites W2074146312 @default.
- W2162377175 cites W2081958959 @default.
- W2162377175 cites W2086644874 @default.
- W2162377175 cites W2088825730 @default.
- W2162377175 cites W2092145002 @default.
- W2162377175 cites W2095921496 @default.
- W2162377175 cites W2096552728 @default.
- W2162377175 cites W2096697445 @default.
- W2162377175 cites W2097492311 @default.
- W2162377175 cites W2097541907 @default.
- W2162377175 cites W2099951056 @default.
- W2162377175 cites W2101200120 @default.
- W2162377175 cites W2103396287 @default.
- W2162377175 cites W2111366049 @default.
- W2162377175 cites W2114908816 @default.
- W2162377175 cites W2115563064 @default.
- W2162377175 cites W2118584840 @default.
- W2162377175 cites W2119355019 @default.
- W2162377175 cites W2126029591 @default.
- W2162377175 cites W2126681269 @default.
- W2162377175 cites W2127600708 @default.
- W2162377175 cites W2128960919 @default.
- W2162377175 cites W2129140197 @default.
- W2162377175 cites W2136781613 @default.
- W2162377175 cites W2139580508 @default.
- W2162377175 cites W2139886523 @default.
- W2162377175 cites W2141769819 @default.