Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162396909> ?p ?o ?g. }
- W2162396909 endingPage "2859" @default.
- W2162396909 startingPage "2849" @default.
- W2162396909 abstract "Liposomes are phospholipid vesicles that have been used as carriers of antigens and adjuvants. Lipid A, the endotoxic moiety of Gram-negative bacterial lipopolysaccharide is a potent adjuvant and incorporation into liposomes essentially reduces the endotoxic activity of lipid A. In this study, we analyzed the effect of liposomal lipid A [L(LA)] on the MHC class I antigen processing machinery in murine antigen presenting cells (APCs). L(LA) enhanced the surface expression of MHC class I, class II, CD80, and CD86 molecules, induced the secretion of IFN-γ, IL-12p40, TNF-α and IL-10, and caused a shift in the proteasome profile from constitutive to immunoproteasomes as observed by the induction of β2i, β5i, PA28α, and PA28β subunits. L(LA) acts through the production of IFN-γ as demonstrated with APCs generated from IFN-γ knockout mice. L(LA) therefore appears to act as an intracellular adjuvant by upregulating the antigen processing machinery, which could result in efficient antigen presentation." @default.
- W2162396909 created "2016-06-24" @default.
- W2162396909 creator A5005601710 @default.
- W2162396909 creator A5007536314 @default.
- W2162396909 creator A5020862678 @default.
- W2162396909 date "2008-06-01" @default.
- W2162396909 modified "2023-10-16" @default.
- W2162396909 title "Modulation of immunoproteasome subunits by liposomal lipid A" @default.
- W2162396909 cites W1608231811 @default.
- W2162396909 cites W1638308529 @default.
- W2162396909 cites W1755125321 @default.
- W2162396909 cites W1872937334 @default.
- W2162396909 cites W1892909481 @default.
- W2162396909 cites W1976775926 @default.
- W2162396909 cites W1978228010 @default.
- W2162396909 cites W1981942683 @default.
- W2162396909 cites W1998405063 @default.
- W2162396909 cites W1999119754 @default.
- W2162396909 cites W2005426040 @default.
- W2162396909 cites W2011325535 @default.
- W2162396909 cites W2014349397 @default.
- W2162396909 cites W2021917303 @default.
- W2162396909 cites W2027328624 @default.
- W2162396909 cites W2028682232 @default.
- W2162396909 cites W2028699526 @default.
- W2162396909 cites W2029698647 @default.
- W2162396909 cites W2030335228 @default.
- W2162396909 cites W2030520158 @default.
- W2162396909 cites W2040498891 @default.
- W2162396909 cites W2051179452 @default.
- W2162396909 cites W2054461329 @default.
- W2162396909 cites W2055017188 @default.
- W2162396909 cites W2073883965 @default.
- W2162396909 cites W2078791944 @default.
- W2162396909 cites W2084234200 @default.
- W2162396909 cites W2084409666 @default.
- W2162396909 cites W2098795075 @default.
- W2162396909 cites W2103980159 @default.
- W2162396909 cites W2107198699 @default.
- W2162396909 cites W2107426217 @default.
- W2162396909 cites W2108906905 @default.
- W2162396909 cites W2109044345 @default.
- W2162396909 cites W2113029463 @default.
- W2162396909 cites W2123781000 @default.
- W2162396909 cites W2126789189 @default.
- W2162396909 cites W2128728706 @default.
- W2162396909 cites W2128897591 @default.
- W2162396909 cites W2134992605 @default.
- W2162396909 cites W2143746835 @default.
- W2162396909 cites W2144318866 @default.
- W2162396909 cites W2144513657 @default.
- W2162396909 cites W2146488386 @default.
- W2162396909 cites W2151925533 @default.
- W2162396909 cites W2154903686 @default.
- W2162396909 cites W2156277550 @default.
- W2162396909 cites W2158614517 @default.
- W2162396909 cites W2163595408 @default.
- W2162396909 cites W2166174984 @default.
- W2162396909 doi "https://doi.org/10.1016/j.vaccine.2008.03.065" @default.
- W2162396909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18455279" @default.
- W2162396909 hasPublicationYear "2008" @default.
- W2162396909 type Work @default.
- W2162396909 sameAs 2162396909 @default.
- W2162396909 citedByCount "14" @default.
- W2162396909 countsByYear W21623969092012 @default.
- W2162396909 countsByYear W21623969092014 @default.
- W2162396909 countsByYear W21623969092015 @default.
- W2162396909 countsByYear W21623969092017 @default.
- W2162396909 countsByYear W21623969092020 @default.
- W2162396909 countsByYear W21623969092021 @default.
- W2162396909 countsByYear W21623969092022 @default.
- W2162396909 crossrefType "journal-article" @default.
- W2162396909 hasAuthorship W2162396909A5005601710 @default.
- W2162396909 hasAuthorship W2162396909A5007536314 @default.
- W2162396909 hasAuthorship W2162396909A5020862678 @default.
- W2162396909 hasConcept C108249834 @default.
- W2162396909 hasConcept C144464004 @default.
- W2162396909 hasConcept C147483822 @default.
- W2162396909 hasConcept C154317977 @default.
- W2162396909 hasConcept C170627219 @default.
- W2162396909 hasConcept C185154212 @default.
- W2162396909 hasConcept C185592680 @default.
- W2162396909 hasConcept C202751555 @default.
- W2162396909 hasConcept C203014093 @default.
- W2162396909 hasConcept C207936829 @default.
- W2162396909 hasConcept C2776090121 @default.
- W2162396909 hasConcept C2777425210 @default.
- W2162396909 hasConcept C2777863537 @default.
- W2162396909 hasConcept C2778297628 @default.
- W2162396909 hasConcept C2778754761 @default.
- W2162396909 hasConcept C2778814158 @default.
- W2162396909 hasConcept C2781101188 @default.
- W2162396909 hasConcept C39347974 @default.
- W2162396909 hasConcept C523546767 @default.
- W2162396909 hasConcept C54355233 @default.
- W2162396909 hasConcept C55493867 @default.
- W2162396909 hasConcept C83464605 @default.
- W2162396909 hasConcept C86803240 @default.