FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162400295> ?p ?o ?g. }

• W2162400295 abstract "To differentiate between the contribution of mammary epithelial cells (MEC) and infiltrating immune cells to gene expression profiles of mammary tissue during early stage mastitis, we investigated in goats the in vivo transcriptional response of MEC to an experimental intra mammary infection (IMI) with Staphylococcus aureus, using a non-invasive RNA sampling method from milk fat globules (MFG). Microarrays were used to record gene expression patterns during the first 24 hours post-infection (hpi). This approach was combined with laser capture microdissection of MEC from frozen slides of mammary tissue to analyze some relevant genes at 30 hpi. During the early stages post-inoculation, MEC play an important role in the recruitment and activation of inflammatory cells through the IL-8 signalling pathway and initiate a sharp induction of innate immune genes predominantly associated with the pro-inflammatory response. At 30 hpi, MEC express genes encoding different acute phase proteins, including SAA3, SERPINA1 and PTX3 and factors, such as S100A12, that contribute directly to fighting the infection. No significant change in the expression of genes encoding caseins was observed until 24 hpi, thus validating our experimental model to study early stages of infection before the occurrence of tissue damage, since the milk synthesis function is still operative. This is to our knowledge the first report showing in vivo, in goats, how MEC orchestrate the innate immune response to an IMI challenge with S. aureus. Moreover, the non-invasive sampling method of mammary representative RNA from MFG provides a valuable tool to easily follow the dynamics of gene expression in MEC to search for sensitive biomarkers in milk for early detection of mastitis and therefore, to successfully improve the treatment and thus animal welfare." @default.
• W2162400295 created "2016-06-24" @default.
• W2162400295 creator A5013609834 @default.
• W2162400295 creator A5014679436 @default.
• W2162400295 creator A5016868874 @default.
• W2162400295 creator A5021612274 @default.
• W2162400295 creator A5045203888 @default.
• W2162400295 creator A5068640821 @default.
• W2162400295 creator A5070900693 @default.
• W2162400295 creator A5073709696 @default.
• W2162400295 date "2014-02-12" @default.
• W2162400295 modified "2023-10-14" @default.
• W2162400295 title "Contribution of mammary epithelial cells to the immune response during early stages of a bacterial infection to Staphylococcus aureus" @default.
• W2162400295 cites W1529698986 @default.
• W2162400295 cites W1546519436 @default.
• W2162400295 cites W1696199194 @default.
• W2162400295 cites W1857206577 @default.
• W2162400295 cites W1977414573 @default.
• W2162400295 cites W1987414738 @default.
• W2162400295 cites W1988543098 @default.
• W2162400295 cites W1989155338 @default.
• W2162400295 cites W1989321397 @default.
• W2162400295 cites W1995615243 @default.
• W2162400295 cites W1998872042 @default.
• W2162400295 cites W2001822779 @default.
• W2162400295 cites W2008081537 @default.
• W2162400295 cites W2008474737 @default.
• W2162400295 cites W2010888304 @default.
• W2162400295 cites W2014900583 @default.
• W2162400295 cites W2016438136 @default.
• W2162400295 cites W2021763936 @default.
• W2162400295 cites W2026700800 @default.
• W2162400295 cites W2027620167 @default.
• W2162400295 cites W2029120605 @default.
• W2162400295 cites W2032591111 @default.
• W2162400295 cites W2037252842 @default.
• W2162400295 cites W2040551905 @default.
• W2162400295 cites W2040836173 @default.
• W2162400295 cites W2043332292 @default.
• W2162400295 cites W2044881041 @default.
• W2162400295 cites W2045690370 @default.
• W2162400295 cites W2053314848 @default.
• W2162400295 cites W2055403920 @default.
• W2162400295 cites W2056345127 @default.
• W2162400295 cites W2057757909 @default.
• W2162400295 cites W2061016132 @default.
• W2162400295 cites W2064955349 @default.
• W2162400295 cites W2065683366 @default.
• W2162400295 cites W2067328369 @default.
• W2162400295 cites W2070677639 @default.
• W2162400295 cites W2082426484 @default.
• W2162400295 cites W2082620866 @default.
• W2162400295 cites W2089844307 @default.
• W2162400295 cites W2097515194 @default.
• W2162400295 cites W2105488052 @default.
• W2162400295 cites W2107140020 @default.
• W2162400295 cites W2107195564 @default.
• W2162400295 cites W2114378552 @default.
• W2162400295 cites W2114426583 @default.
• W2162400295 cites W2117457279 @default.
• W2162400295 cites W2118507136 @default.
• W2162400295 cites W2119293827 @default.
• W2162400295 cites W2120738511 @default.
• W2162400295 cites W2125057273 @default.
• W2162400295 cites W2125703545 @default.
• W2162400295 cites W2127507330 @default.
• W2162400295 cites W2132681751 @default.
• W2162400295 cites W2132970698 @default.
• W2162400295 cites W2133912398 @default.
• W2162400295 cites W2138581811 @default.
• W2162400295 cites W2143516276 @default.
• W2162400295 cites W2144159138 @default.
• W2162400295 cites W2146438991 @default.
• W2162400295 cites W2154811349 @default.
• W2162400295 cites W2155430529 @default.
• W2162400295 cites W2157339124 @default.
• W2162400295 cites W2159195608 @default.
• W2162400295 cites W2167335693 @default.
• W2162400295 cites W2168420558 @default.
• W2162400295 cites W2171994438 @default.
• W2162400295 cites W2242142163 @default.
• W2162400295 cites W27333232 @default.
• W2162400295 doi "https://doi.org/10.1186/1297-9716-45-16" @default.
• W2162400295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3937043" @default.
• W2162400295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521038" @default.
• W2162400295 hasPublicationYear "2014" @default.
• W2162400295 type Work @default.
• W2162400295 sameAs 2162400295 @default.
• W2162400295 citedByCount "66" @default.
• W2162400295 countsByYear W21624002952014 @default.
• W2162400295 countsByYear W21624002952015 @default.
• W2162400295 countsByYear W21624002952016 @default.
• W2162400295 countsByYear W21624002952017 @default.
• W2162400295 countsByYear W21624002952018 @default.
• W2162400295 countsByYear W21624002952019 @default.
• W2162400295 countsByYear W21624002952020 @default.
• W2162400295 countsByYear W21624002952021 @default.
• W2162400295 countsByYear W21624002952022 @default.
• W2162400295 countsByYear W21624002952023 @default.
• W2162400295 crossrefType "journal-article" @default.

• next