FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162424559> ?p ?o ?g. }

• W2162424559 endingPage "723" @default.
• W2162424559 startingPage "714" @default.
• W2162424559 abstract "The plasma concentrations of orally administered anti-human immunodeficiency virus protease inhibitors are significantly reduced during human and mouse pregnancy. We have shown that in the mouse, at gestational day 19, this reduction is due to increased hepatic cytochrome P450 3a (Cyp3a) protein expression and activity. In the current study, we investigated the mechanisms by which Cyp3a activity is increased by pregnancy and the time course of change in expression of Cyp3a and P-glycoprotein (P-gp) in various tissues. We found that hepatic transcripts of Cyp3a16, Cyp3a41, and Cyp3a44 were significantly increased during pregnancy, whereas those of Cyp3a11 and Cyp3a25 were significantly decreased. This resulted in a net increase in Cyp3a protein expression and activity in the liver during pregnancy. The increase in Cyp3a41 and Cyp3a44 transcripts was positively correlated (<i>p</i> < 0.05) with hepatocyte nuclear factor 6 and estrogen receptor-α transcripts. The pregnancy-related factors that transcriptionally activated mouse Cyp3a isoforms also activated the human CYP3A4 promoter in pregnant CYP3A4-promoter-luciferase transgenic (CYP3A4-tg) mice. In contrast, intestinal Cyp3a protein expression was not significantly affected by pregnancy. No change in P-gp protein expression was observed in the liver or kidney during pregnancy, although a significant decrease was observed in the placenta. Because hepatic CYP3A activity also seems to be induced during human pregnancy, the mouse (including CYP3A4-tg mouse) seems to be an excellent animal model to determine the molecular mechanisms for such an induction." @default.
• W2162424559 created "2016-06-24" @default.
• W2162424559 creator A5012272600 @default.
• W2162424559 creator A5019762142 @default.
• W2162424559 creator A5020600016 @default.
• W2162424559 creator A5046720938 @default.
• W2162424559 creator A5051060799 @default.
• W2162424559 creator A5091165765 @default.
• W2162424559 date "2008-05-28" @default.
• W2162424559 modified "2023-10-11" @default.
• W2162424559 title "Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course" @default.
• W2162424559 cites W1787868867 @default.
• W2162424559 cites W1829170701 @default.
• W2162424559 cites W1848709375 @default.
• W2162424559 cites W1966378611 @default.
• W2162424559 cites W1969866963 @default.
• W2162424559 cites W1970111900 @default.
• W2162424559 cites W1982557234 @default.
• W2162424559 cites W1995544748 @default.
• W2162424559 cites W1996141972 @default.
• W2162424559 cites W1997157738 @default.
• W2162424559 cites W1998622278 @default.
• W2162424559 cites W2006134717 @default.
• W2162424559 cites W2013294210 @default.
• W2162424559 cites W2036909895 @default.
• W2162424559 cites W2038025308 @default.
• W2162424559 cites W2044139531 @default.
• W2162424559 cites W2049626093 @default.
• W2162424559 cites W2052229830 @default.
• W2162424559 cites W2067184672 @default.
• W2162424559 cites W2074576600 @default.
• W2162424559 cites W2078567720 @default.
• W2162424559 cites W2079396863 @default.
• W2162424559 cites W2103977313 @default.
• W2162424559 cites W2110222367 @default.
• W2162424559 cites W2111014207 @default.
• W2162424559 cites W2113283528 @default.
• W2162424559 cites W2116910113 @default.
• W2162424559 cites W2118132259 @default.
• W2162424559 cites W2123052686 @default.
• W2162424559 cites W2148032486 @default.
• W2162424559 cites W2150649807 @default.
• W2162424559 cites W2157902463 @default.
• W2162424559 cites W2161658343 @default.
• W2162424559 cites W4236156914 @default.
• W2162424559 cites W4237985641 @default.
• W2162424559 cites W4249707422 @default.
• W2162424559 cites W4300011144 @default.
• W2162424559 doi "https://doi.org/10.1124/mol.107.043851" @default.
• W2162424559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574889" @default.
• W2162424559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18509067" @default.
• W2162424559 hasPublicationYear "2008" @default.
• W2162424559 type Work @default.
• W2162424559 sameAs 2162424559 @default.
• W2162424559 citedByCount "82" @default.
• W2162424559 countsByYear W21624245592012 @default.
• W2162424559 countsByYear W21624245592013 @default.
• W2162424559 countsByYear W21624245592014 @default.
• W2162424559 countsByYear W21624245592015 @default.
• W2162424559 countsByYear W21624245592016 @default.
• W2162424559 countsByYear W21624245592017 @default.
• W2162424559 countsByYear W21624245592018 @default.
• W2162424559 countsByYear W21624245592019 @default.
• W2162424559 countsByYear W21624245592020 @default.
• W2162424559 countsByYear W21624245592021 @default.
• W2162424559 countsByYear W21624245592022 @default.
• W2162424559 countsByYear W21624245592023 @default.
• W2162424559 crossrefType "journal-article" @default.
• W2162424559 hasAuthorship W2162424559A5012272600 @default.
• W2162424559 hasAuthorship W2162424559A5019762142 @default.
• W2162424559 hasAuthorship W2162424559A5020600016 @default.
• W2162424559 hasAuthorship W2162424559A5046720938 @default.
• W2162424559 hasAuthorship W2162424559A5051060799 @default.
• W2162424559 hasAuthorship W2162424559A5091165765 @default.
• W2162424559 hasBestOaLocation W21624245592 @default.
• W2162424559 hasConcept C104317684 @default.
• W2162424559 hasConcept C109650736 @default.
• W2162424559 hasConcept C11824378 @default.
• W2162424559 hasConcept C126322002 @default.
• W2162424559 hasConcept C134018914 @default.
• W2162424559 hasConcept C150194340 @default.
• W2162424559 hasConcept C153911025 @default.
• W2162424559 hasConcept C172680121 @default.
• W2162424559 hasConcept C2776953305 @default.
• W2162424559 hasConcept C2779234561 @default.
• W2162424559 hasConcept C526171541 @default.
• W2162424559 hasConcept C53345823 @default.
• W2162424559 hasConcept C54355233 @default.
• W2162424559 hasConcept C55493867 @default.
• W2162424559 hasConcept C62231903 @default.
• W2162424559 hasConcept C71924100 @default.
• W2162424559 hasConcept C86803240 @default.
• W2162424559 hasConceptScore W2162424559C104317684 @default.
• W2162424559 hasConceptScore W2162424559C109650736 @default.
• W2162424559 hasConceptScore W2162424559C11824378 @default.
• W2162424559 hasConceptScore W2162424559C126322002 @default.
• W2162424559 hasConceptScore W2162424559C134018914 @default.
• W2162424559 hasConceptScore W2162424559C150194340 @default.

• next