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- W2162429758 abstract "NK cell receptors (NKR) are expressed in subsets of NK and CD8+ T cells, lymphocytes involved in multiple sclerosis (MS) pathogenesis. Clinical implications of NKR expression in MS are unknown. Here, we show that the proportions of CD8+ T cells displaying LILRB1, an inhibitory NKR expressed at late stages of T cell differentiation, were directly related with age and MS duration, and inversely with the immunomodulatory therapy-dependent increase of CD56(bright) NK cells. Similar associations were found for KIR+ and CD56+ CD8+ T cells, whereas no age-related NKR distribution was perceived in controls. Moreover, active MS had lower LILRB1+ NK cells, and IFN-β-treated patients exhibited a phenotypic profile related to shorter disease evolution. Progressive accumulation of terminally differentiated T lymphocytes and experienced NK cells in MS, presumably stimulated in response to a persistent challenge and modulated by IFN-β therapy, may support the analysis of NKR distribution as new biomarkers." @default.
- W2162429758 created "2016-06-24" @default.
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- W2162429758 date "2010-10-01" @default.
- W2162429758 modified "2023-10-17" @default.
- W2162429758 title "Natural killer receptors distribution in multiple sclerosis: Relation to clinical course and interferon-beta therapy" @default.
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- W2162429758 doi "https://doi.org/10.1016/j.clim.2010.06.002" @default.
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