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- W2162438863 abstract "Histone deacetylase (HDAC) inhibitors are a new class of targeted anticancer agents. Several HDAC inhibitors are in clinical trials and have shown significant activity against a spectrum of both haematological and solid tumours at doses that are well tolerated by patients. HDACs and histone acetyltransferases can, by reversible acetylation, modify the structure and function of histones and proteins in transcription factor complexes, which are involved in the regulation of gene expression, as well as many non-histone proteins that are involved in regulating cell proliferation and cell death. HDAC inhibitors are a structurally diverse group of molecules; these agents selectively alter the expression of genes. HDAC inhibitors can induce cancer cell death, whereas normal cells are relatively resistant to HDAC inhibitor-induced cell death." @default.
- W2162438863 created "2016-06-24" @default.
- W2162438863 creator A5062949690 @default.
- W2162438863 creator A5078159824 @default.
- W2162438863 date "2005-11-25" @default.
- W2162438863 modified "2023-10-18" @default.
- W2162438863 title "Histone deacetylase inhibitors: discovery and development as anticancer agents" @default.
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- W2162438863 doi "https://doi.org/10.1517/13543784.14.12.1497" @default.
- W2162438863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16307490" @default.
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