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• W2162452021 abstract "Abstract LFA-1 (CD18,CD11a) is a cell-adhesion molecule that mediates critical immunological processes. In this paper we report the discovery and characterization of (R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione (BIRT 377), an orally bioavailable small molecule that interacts specifically with LFA-1 via noncovalent binding to the CD11a chain and prevents LFA-1 from binding to its ligand, ICAM-1. BIRT 377 inhibits lymphocyte activity both in vitro and in vivo, in functional assays that require LFA-1-mediated cell adhesion. These results demonstrate that LFA-1-mediated leukocyte adhesion can be antagonized with noncharged, low m.w. molecules and suggest that the potential therapeutic value of adhesion inhibitors can be attained with a small, orally bioavailable compound." @default.
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• W2162452021 date "1999-11-15" @default.
• W2162452021 modified "2023-10-10" @default.
• W2162452021 title "Cutting Edge: A Small Molecule Antagonist of LFA-1-Mediated Cell Adhesion" @default.
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• W2162452021 doi "https://doi.org/10.4049/jimmunol.163.10.5173" @default.
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