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- W2162479439 abstract "The tumor microenvironment is a complex milieu of tumor and host cells. Host cells can include tumor-reactive T cells capable of killing tumor cells. However, more frequently tumor and host components interact to generate a highly immune suppressive environment that frustrates T cell cytotoxicity and promotes tumor progression through a variety of immune and non-immune mechanisms. Myeloid-derived suppressor cells (MDSC) are a major host component contributing to the immune suppressive environment. MDSC accumulate in most patients and experimental mice with cancer. They inhibit both adaptive and innate immunity through a diverse array of suppressive mechanisms and therefore are a significant obstacle for natural immunity and for active cancer immunotherapies. Their accumulation and suppressive potency are driven by pro-inflammatory mediators. In addition to their inherent immune suppressive function, MDSC amplify the immune suppressive activity of macrophages and dendritic cells via cross-talk which results in the up-regulation of inflammatory mediators. Cross-talk between MDSC and other myeloid cells is itself enhanced by inflammation, resulting in an autocrine tumor microenvironment that sustains and amplifies immune suppression. This talk will describe the cell-cell interactions used by MDSC to inhibit anti-tumor immunity and promote tumor progression, and the role of inflammation in promoting cross-talk between MDSC and other cells in the tumor microenvironment." @default.
- W2162479439 created "2016-06-24" @default.
- W2162479439 creator A5022466116 @default.
- W2162479439 date "2013-04-01" @default.
- W2162479439 modified "2023-09-24" @default.
- W2162479439 title "Inflammation, immune suppression, and tumor progression" @default.
- W2162479439 doi "https://doi.org/10.1186/1753-6561-7-s2-k20" @default.
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