FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162489885> ?p ?o ?g. }

• W2162489885 endingPage "13898" @default.
• W2162489885 startingPage "13893" @default.
• W2162489885 abstract "Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially Gq, whose alpha subunit activates phospholipase Cbeta (PLCbeta). We now report that transient, modest expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the Gq alpha subunit (HAalpha*q) in hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after the initiating stimulus becomes undetectable. At 2 weeks, HAalpha*q protein is expressed at less than 50% of endogenous alphaq/11, and the transgenic hearts are essentially normal morphologically. Although HAalpha*q protein declines at 4 weeks and is undetectable by 10 weeks, the animals develop cardiac hypertrophy and dilatation and die between 8 and 30 weeks in heart failure. As the pathology develops, endogenous alphaq/11 rises (2.9-fold in atria; 1.8-fold in ventricles). At 2 weeks, basal PLC activity is increased 9- to 10-fold in atria but not ventricles. By 10 weeks, it is elevated in both, presumably because of the rise in endogenous alphaq/11. We conclude that the pathological changes initiated by early, transient HAalpha*q expression are maintained in part by compensatory changes in signal transduction and other pathways. Cyclosporin A (CsA) prevents hypertrophy caused by activation of calcineurin [Molkentin, J. D., Lu, J.-R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R. & Olson, E. N. (1998) Cell 93, 215-228]. Because HAalpha*q acts upstream of calcineurin, we hypothesized that HAalpha*q might initiate additional pathways leading to hypertrophy and dilatation. Treating HAalpha*q mice with CsA diminished some, but not all, aspects of the hypertrophic phenotype, suggesting that multiple pathways are involved." @default.
• W2162489885 created "2016-06-24" @default.
• W2162489885 creator A5010608509 @default.
• W2162489885 creator A5020486323 @default.
• W2162489885 creator A5050753554 @default.
• W2162489885 creator A5059764261 @default.
• W2162489885 creator A5065318834 @default.
• W2162489885 creator A5065951914 @default.
• W2162489885 date "1998-11-10" @default.
• W2162489885 modified "2023-10-17" @default.
• W2162489885 title "Transient cardiac expression of constitutively active Gα_qleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways" @default.
• W2162489885 cites W1483263363 @default.
• W2162489885 cites W1515692272 @default.
• W2162489885 cites W1525008978 @default.
• W2162489885 cites W1549603309 @default.
• W2162489885 cites W1585057157 @default.
• W2162489885 cites W1793242705 @default.
• W2162489885 cites W1973557736 @default.
• W2162489885 cites W1979547677 @default.
• W2162489885 cites W2000987425 @default.
• W2162489885 cites W2005339591 @default.
• W2162489885 cites W2010791119 @default.
• W2162489885 cites W2018289835 @default.
• W2162489885 cites W2030016364 @default.
• W2162489885 cites W2049401019 @default.
• W2162489885 cites W2056982291 @default.
• W2162489885 cites W2080268147 @default.
• W2162489885 cites W2082201094 @default.
• W2162489885 cites W2084510672 @default.
• W2162489885 cites W2085822013 @default.
• W2162489885 cites W2100837269 @default.
• W2162489885 cites W2101108802 @default.
• W2162489885 cites W2113934901 @default.
• W2162489885 cites W2128635872 @default.
• W2162489885 cites W2141986088 @default.
• W2162489885 cites W2150817394 @default.
• W2162489885 cites W2156433522 @default.
• W2162489885 cites W4293247451 @default.
• W2162489885 doi "https://doi.org/10.1073/pnas.95.23.13893" @default.
• W2162489885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24952" @default.
• W2162489885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9811897" @default.
• W2162489885 hasPublicationYear "1998" @default.
• W2162489885 type Work @default.
• W2162489885 sameAs 2162489885 @default.
• W2162489885 citedByCount "248" @default.
• W2162489885 countsByYear W21624898852012 @default.
• W2162489885 countsByYear W21624898852013 @default.
• W2162489885 countsByYear W21624898852014 @default.
• W2162489885 countsByYear W21624898852015 @default.
• W2162489885 countsByYear W21624898852016 @default.
• W2162489885 countsByYear W21624898852017 @default.
• W2162489885 countsByYear W21624898852018 @default.
• W2162489885 countsByYear W21624898852019 @default.
• W2162489885 countsByYear W21624898852020 @default.
• W2162489885 countsByYear W21624898852021 @default.
• W2162489885 countsByYear W21624898852022 @default.
• W2162489885 countsByYear W21624898852023 @default.
• W2162489885 crossrefType "journal-article" @default.
• W2162489885 hasAuthorship W2162489885A5010608509 @default.
• W2162489885 hasAuthorship W2162489885A5020486323 @default.
• W2162489885 hasAuthorship W2162489885A5050753554 @default.
• W2162489885 hasAuthorship W2162489885A5059764261 @default.
• W2162489885 hasAuthorship W2162489885A5065318834 @default.
• W2162489885 hasAuthorship W2162489885A5065951914 @default.
• W2162489885 hasBestOaLocation W21624898851 @default.
• W2162489885 hasConcept C126322002 @default.
• W2162489885 hasConcept C128057223 @default.
• W2162489885 hasConcept C134018914 @default.
• W2162489885 hasConcept C139407321 @default.
• W2162489885 hasConcept C16613235 @default.
• W2162489885 hasConcept C167414201 @default.
• W2162489885 hasConcept C2911091166 @default.
• W2162489885 hasConcept C62478195 @default.
• W2162489885 hasConcept C66135807 @default.
• W2162489885 hasConcept C71924100 @default.
• W2162489885 hasConcept C80631254 @default.
• W2162489885 hasConcept C86803240 @default.
• W2162489885 hasConcept C95444343 @default.
• W2162489885 hasConceptScore W2162489885C126322002 @default.
• W2162489885 hasConceptScore W2162489885C128057223 @default.
• W2162489885 hasConceptScore W2162489885C134018914 @default.
• W2162489885 hasConceptScore W2162489885C139407321 @default.
• W2162489885 hasConceptScore W2162489885C16613235 @default.
• W2162489885 hasConceptScore W2162489885C167414201 @default.
• W2162489885 hasConceptScore W2162489885C2911091166 @default.
• W2162489885 hasConceptScore W2162489885C62478195 @default.
• W2162489885 hasConceptScore W2162489885C66135807 @default.
• W2162489885 hasConceptScore W2162489885C71924100 @default.
• W2162489885 hasConceptScore W2162489885C80631254 @default.
• W2162489885 hasConceptScore W2162489885C86803240 @default.
• W2162489885 hasConceptScore W2162489885C95444343 @default.
• W2162489885 hasIssue "23" @default.
• W2162489885 hasLocation W21624898851 @default.
• W2162489885 hasLocation W21624898852 @default.
• W2162489885 hasLocation W21624898853 @default.
• W2162489885 hasLocation W21624898854 @default.
• W2162489885 hasOpenAccess W2162489885 @default.
• W2162489885 hasPrimaryLocation W21624898851 @default.

• next