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• W2162507320 endingPage "i76" @default.
• W2162507320 startingPage "i71" @default.
• W2162507320 abstract "Evaluation of the preclinical phases of the classic autoimmune diseases including rheumatoid arthritis has been facilitated by the availability of autoantibody and genetic markers that point firmly towards the early dysregulation of the adaptive immune responses. The association of psoriatic disease with the human leucocyte antigen-Cw0602 (HLA-Cw0602) gene has likewise led to the perception that autoimmunity has a pivotal role in early psoriatic arthritis (PsA). However, this HLA-Cw0602 genetic association does not appear to hold for PsA or associated nail, scalp and intergluteal skin involvement. Of note, these three sites of psoriasis are predictive of PsA evolution. For initiation of both skin and nail disease there is a link with Koebnerisation, or site-specific trauma. Nail disease is most common in the dominant hand thumbnail, pointing towards local tissue factors as disease initiators Likewise, for PsA, there is also good evidence for a history of previous joint trauma and histological studies showing microdamage in normal entheses which are typical locations where PsA frequently occurs. Furthermore, subclinical enthesopathy including osteitis is common in subjects with psoriasis but without arthritis. Collectively, these findings indicate that the classic model of adaptive immune dysregulation does not generally hold for the early stages of PsA. The way in which knowledge pertaining to tissue-specific factors in PsA, combined with the emerging data relating to monogenic disorders and animal models, points towards perturbation in the healing response and dysregulation of innate immune responses in early PsA is discussed. The way in which this model explains the clinical disconnect between skin and joint disease and the emerging human data that support it are demonstrated." @default.
• W2162507320 created "2016-06-24" @default.
• W2162507320 creator A5028241466 @default.
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• W2162507320 creator A5067816670 @default.
• W2162507320 creator A5070110978 @default.
• W2162507320 creator A5071307383 @default.
• W2162507320 date "2011-02-21" @default.
• W2162507320 modified "2023-10-01" @default.
• W2162507320 title "The early phase of psoriatic arthritis" @default.
• W2162507320 cites W1531782982 @default.
• W2162507320 cites W1536738721 @default.
• W2162507320 cites W1770660935 @default.
• W2162507320 cites W177448983 @default.
• W2162507320 cites W1963753552 @default.
• W2162507320 cites W1964344423 @default.
• W2162507320 cites W1966731757 @default.
• W2162507320 cites W1974197489 @default.
• W2162507320 cites W1974388623 @default.
• W2162507320 cites W1979134782 @default.
• W2162507320 cites W1981118183 @default.
• W2162507320 cites W1981143087 @default.
• W2162507320 cites W1988657504 @default.
• W2162507320 cites W1998531275 @default.
• W2162507320 cites W2003511807 @default.
• W2162507320 cites W2004570403 @default.
• W2162507320 cites W2005687682 @default.
• W2162507320 cites W2007386671 @default.
• W2162507320 cites W2008286701 @default.
• W2162507320 cites W2011757107 @default.
• W2162507320 cites W2014459971 @default.
• W2162507320 cites W2015805011 @default.
• W2162507320 cites W2016276268 @default.
• W2162507320 cites W2016475067 @default.
• W2162507320 cites W2019872773 @default.
• W2162507320 cites W2020581629 @default.
• W2162507320 cites W2020906240 @default.
• W2162507320 cites W2025549014 @default.
• W2162507320 cites W2033342396 @default.
• W2162507320 cites W2034666462 @default.
• W2162507320 cites W2041084308 @default.
• W2162507320 cites W2044464177 @default.
• W2162507320 cites W2045113343 @default.
• W2162507320 cites W2047961787 @default.
• W2162507320 cites W2056818487 @default.
• W2162507320 cites W2056840860 @default.
• W2162507320 cites W2057835792 @default.
• W2162507320 cites W2060529824 @default.
• W2162507320 cites W2061147684 @default.
• W2162507320 cites W2062734170 @default.
• W2162507320 cites W2069091961 @default.
• W2162507320 cites W2071089553 @default.
• W2162507320 cites W2082681418 @default.
• W2162507320 cites W2083062923 @default.
• W2162507320 cites W2083816377 @default.
• W2162507320 cites W2086334974 @default.
• W2162507320 cites W2088119058 @default.
• W2162507320 cites W2092311269 @default.
• W2162507320 cites W2093859816 @default.
• W2162507320 cites W2098689226 @default.
• W2162507320 cites W2103089222 @default.
• W2162507320 cites W2105738742 @default.
• W2162507320 cites W2105842551 @default.
• W2162507320 cites W2107242220 @default.
• W2162507320 cites W2109481129 @default.
• W2162507320 cites W2109824852 @default.
• W2162507320 cites W2110270819 @default.
• W2162507320 cites W2115055244 @default.
• W2162507320 cites W2115361796 @default.
• W2162507320 cites W2116232969 @default.
• W2162507320 cites W2123114243 @default.
• W2162507320 cites W2123467985 @default.
• W2162507320 cites W2123998087 @default.
• W2162507320 cites W2124465016 @default.
• W2162507320 cites W2128598518 @default.
• W2162507320 cites W2128847448 @default.
• W2162507320 cites W2130849049 @default.
• W2162507320 cites W2132378789 @default.
• W2162507320 cites W2134880592 @default.
• W2162507320 cites W2137906392 @default.
• W2162507320 cites W2141564385 @default.
• W2162507320 cites W2141609479 @default.
• W2162507320 cites W2144614378 @default.
• W2162507320 cites W2146739989 @default.
• W2162507320 cites W2149713883 @default.
• W2162507320 cites W2152653766 @default.
• W2162507320 cites W2155111110 @default.
• W2162507320 cites W2158620918 @default.
• W2162507320 cites W2159052144 @default.
• W2162507320 cites W2162089651 @default.
• W2162507320 cites W2167905575 @default.
• W2162507320 cites W2168927567 @default.
• W2162507320 cites W2169001554 @default.
• W2162507320 cites W2169022817 @default.
• W2162507320 cites W2321571214 @default.
• W2162507320 cites W2333925426 @default.
• W2162507320 cites W2396280519 @default.
• W2162507320 cites W2412104479 @default.

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