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• W2162524600 abstract "The T-cell hypothesis of asthma, particularly chronic asthma, is based around the concept that the disease is 'driven' and maintained by the persistence of a specialized subset of chronically activated T-memory cells, sensitized against an array of allergenic, occupational or viral antigens that 'home' to the lung after appropriate antigen exposure or viral infection. Allergens induce a CD4 T-helper (Th) cell response, whereas viruses recognize CD8+ cytotoxic (Tc) cells. In the asthmatic airways there appears to be both CD4+ and CD8+ cells with a type 2 cytokine phenotype (i.e. Th2-and Tc2-types). These cells produce interleukin (IL)-5, IL-3 and granulocyte/macrophage-colony stimulating factor, which recruit, mobilize and activate eosinophils for subsequent mucosal tissue damage, and IL-4, an essential co-factor for local or generalized immunoglobulin (Ig) E production. This in turn leads to 'eosinophilic desquamative bronchitis' with epithelial shedding, mucus hypersecretion and bronchial smooth muscle contraction. Thus, although the eosinophil is believed to produce airway damage, function appears to be under T cell control. Support for this hypothesis includes the observations that activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, nonatopic ('intrinsic') and occupational asthma), the colocalization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma, the presence of chronically activated cytokine-producing T cells in corticosteroid-resistant asthma, the association of disease severity with type 2 cytokines, particularly IL-5, and the efficacy of cyclosporine A in chronic steroid-dependent disease. Inhibitors and/or antagonists directed against more precise t cell-associated molecular targets hold promise for the future treatment of chronic asthma." @default.
• W2162524600 created "2016-06-24" @default.
• W2162524600 creator A5022388448 @default.
• W2162524600 date "1997-01-01" @default.
• W2162524600 modified "2023-09-23" @default.
• W2162524600 title "Role of T cells in asthma" @default.
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• W2162524600 doi "https://doi.org/10.2332/allergolint.46.73" @default.
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