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• W2162540908 abstract "OBJECTIVE: The MS is critical to chromosome segregation and embryo competence. Today, polarized light microscopy (PM) affords non-invasive MS evaluation (MSE). We perform PM 2 h post-harvest and 1 h post-thaw. Here, we appraise its value. DESIGN: Retrospective. MATERIALS AND METHODS: 28 OC cycles with thaw were assessed; ½ eggs were slow frozen and ½ vitrified (vit); pt's eggs were split between methods. MSE was done in the last 23 cycles. Outcome measures included 2PN fertilization (2PN-F), embryo quality suitable for ET, blast formation rate (BFR), and embryo usability (transferred or refrozen). RESULTS: All eggs were from women <38 (mean 31) yo with normal D3 FSH/E2. Of 28 cycles, 57% had pregnancy; 12 delivered 17 liveborns, 3 are ongoing and 1 aborted. In the last 25 cycles, 286 MII eggs were thawed after cryo for a mean of 3 mos; pre-cryo, 83% were MS positive (SP+). 255 (89%) survived; 89% were SP+ post-thaw, a 94% pre-cryo and post-thaw MSE correlation. 211 (83%) ICSI'd eggs achieved 2PN-F. 2.3 embryos were transferred/cycle (30 slow & 22 vit). Pre-cryo MSE: no difference was noted in egg survival or 2PN-F. 65% of SP+ vs. 44% of MS negative (SP-) zygotes became embryos suitable for ET D3 post-thaw (p=.02). No difference was noted in the BFR or % of embryos suitable for D5 ET, but 86% of embryos transferred or refrozen were from SP+ eggs. Post-thaw MSE: no difference was noted in the % of embryos suitable for ET D3 post-thaw or BFR. A significantly higher % of embryos were suitable for ET D5 post-thaw in the SP+ (57%) vs. SP- (29%) groups (p=.03) and 95% of transferred or refrozen embryos were from SP+ oocytes. When comparing MSE data for slow vs. vit eggs, no differences were noted. CONCLUSIONS: Most retrieved oocytes (slow and vit) exhibited a MS pre & post-thaw and most transferred or refrozen embryos were from SP+ oocytes. OC does not appear to damage the MS and viewing it may correlate with oocyte competence. Because MSE may improve efficiency of gamete selection, it should be considered to advance the field of OC." @default.
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• W2162540908 date "2009-09-01" @default.
• W2162540908 modified "2023-10-07" @default.
• W2162540908 title "Non-invasive pre-cryo and post-thaw meiotic spindle (MS) evaluation of human oocytes cyropreserved (OC) by either slow freezing or vitrification: a value or time wasted?" @default.
• W2162540908 doi "https://doi.org/10.1016/j.fertnstert.2009.07.1423" @default.
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