FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162551372> ?p ?o ?g. }

• W2162551372 endingPage "2862" @default.
• W2162551372 startingPage "2857" @default.
• W2162551372 abstract "To clarify the role of estrogen on male pituitary function, the effects of different doses of transdermal E2 on pituitary secretion were evaluated in a man with aromatase deficiency. The study protocol was divided into the following three phases: no E2 treatment (phase 1); 25 microg transdermal E2 twice weekly for 9 months (phase 2);12.5 microg transdermal E2 twice weekly for 9 months (phase 3). Pituitary function was studied in detail during each phase of the study protocol by measuring hormone levels in basal conditions and after dynamic testing (GnRH, insulin tolerance test, GHRH plus arginine, TRH, and corticotropin-releasing factor; tests). Basal and GnRH-stimulated gonadotropin levels resulted inversely related to E2 serum levels, according to the dosage of estrogen administered. Basal and stimulated GH, PRL, and TSH serum levels did not change during the protocol study. The secretory pituitary reserve of GH was clearly impaired. Basal and stimulated ACTH and cortisol serum levels were not modified by estrogen administration. This study demonstrated that in the human male E2 is required at pituitary level for normal functioning of gonadotropin feedback both in basal and stimulated conditions. In this patient GH deficiency seems to be an adult-onset event since he reached a tall stature. However, the finding of a severe impairment in GH response to potent provocative stimuli together with the insensitivity of GH/IGF-I axis to circulating estrogens strongly suggest a possible involvement of estrogens on both the development and maturation of the somatotrophic axis. Finally, the congenital lack of estrogen activity seems to be associated with a slightly impaired secretion of PRL and TSH, suggesting a possible role of estrogens on the pituitary secretion of these hormones in the human male." @default.
• W2162551372 created "2016-06-24" @default.
• W2162551372 creator A5018138329 @default.
• W2162551372 creator A5019760526 @default.
• W2162551372 creator A5022257984 @default.
• W2162551372 creator A5037970500 @default.
• W2162551372 creator A5041064460 @default.
• W2162551372 creator A5091324311 @default.
• W2162551372 date "2002-06-01" @default.
• W2162551372 modified "2023-09-28" @default.
• W2162551372 title "Pituitary Function in a Man with Congenital Aromatase Deficiency: Effect of Different Doses of Transdermal E2 on Basal and Stimulated Pituitary Hormones" @default.
• W2162551372 cites W101215940 @default.
• W2162551372 cites W1521559908 @default.
• W2162551372 cites W1972415367 @default.
• W2162551372 cites W1973610322 @default.
• W2162551372 cites W1973830217 @default.
• W2162551372 cites W1986617642 @default.
• W2162551372 cites W2000202544 @default.
• W2162551372 cites W2002676453 @default.
• W2162551372 cites W2012733509 @default.
• W2162551372 cites W2013986549 @default.
• W2162551372 cites W2024591573 @default.
• W2162551372 cites W2024832428 @default.
• W2162551372 cites W2033395925 @default.
• W2162551372 cites W2043180744 @default.
• W2162551372 cites W2044589398 @default.
• W2162551372 cites W2048551070 @default.
• W2162551372 cites W2054035423 @default.
• W2162551372 cites W2054267961 @default.
• W2162551372 cites W2055672081 @default.
• W2162551372 cites W2061398909 @default.
• W2162551372 cites W2081095883 @default.
• W2162551372 cites W2081275095 @default.
• W2162551372 cites W2082166418 @default.
• W2162551372 cites W2090835089 @default.
• W2162551372 cites W2096571842 @default.
• W2162551372 cites W2102385712 @default.
• W2162551372 cites W2102433335 @default.
• W2162551372 cites W2118065476 @default.
• W2162551372 cites W2125705063 @default.
• W2162551372 cites W2131241813 @default.
• W2162551372 cites W2134674714 @default.
• W2162551372 cites W2135564135 @default.
• W2162551372 cites W2136672074 @default.
• W2162551372 cites W2142402641 @default.
• W2162551372 cites W2146408916 @default.
• W2162551372 cites W2152925090 @default.
• W2162551372 cites W2157613085 @default.
• W2162551372 cites W2166527098 @default.
• W2162551372 cites W2168070229 @default.
• W2162551372 cites W2321613759 @default.
• W2162551372 cites W2324075496 @default.
• W2162551372 cites W2518891029 @default.
• W2162551372 doi "https://doi.org/10.1210/jcem.87.6.8556" @default.
• W2162551372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12050263" @default.
• W2162551372 hasPublicationYear "2002" @default.
• W2162551372 type Work @default.
• W2162551372 sameAs 2162551372 @default.
• W2162551372 citedByCount "26" @default.
• W2162551372 countsByYear W21625513722012 @default.
• W2162551372 countsByYear W21625513722014 @default.
• W2162551372 countsByYear W21625513722015 @default.
• W2162551372 countsByYear W21625513722016 @default.
• W2162551372 countsByYear W21625513722017 @default.
• W2162551372 countsByYear W21625513722018 @default.
• W2162551372 countsByYear W21625513722020 @default.
• W2162551372 countsByYear W21625513722023 @default.
• W2162551372 crossrefType "journal-article" @default.
• W2162551372 hasAuthorship W2162551372A5018138329 @default.
• W2162551372 hasAuthorship W2162551372A5019760526 @default.
• W2162551372 hasAuthorship W2162551372A5022257984 @default.
• W2162551372 hasAuthorship W2162551372A5037970500 @default.
• W2162551372 hasAuthorship W2162551372A5041064460 @default.
• W2162551372 hasAuthorship W2162551372A5091324311 @default.
• W2162551372 hasBestOaLocation W21625513721 @default.
• W2162551372 hasConcept C121608353 @default.
• W2162551372 hasConcept C126322002 @default.
• W2162551372 hasConcept C134018914 @default.
• W2162551372 hasConcept C2776166826 @default.
• W2162551372 hasConcept C2776583789 @default.
• W2162551372 hasConcept C2777164284 @default.
• W2162551372 hasConcept C2778024521 @default.
• W2162551372 hasConcept C2778782382 @default.
• W2162551372 hasConcept C2779029589 @default.
• W2162551372 hasConcept C2779064019 @default.
• W2162551372 hasConcept C2779306644 @default.
• W2162551372 hasConcept C530470458 @default.
• W2162551372 hasConcept C71315377 @default.
• W2162551372 hasConcept C71924100 @default.
• W2162551372 hasConceptScore W2162551372C121608353 @default.
• W2162551372 hasConceptScore W2162551372C126322002 @default.
• W2162551372 hasConceptScore W2162551372C134018914 @default.
• W2162551372 hasConceptScore W2162551372C2776166826 @default.
• W2162551372 hasConceptScore W2162551372C2776583789 @default.
• W2162551372 hasConceptScore W2162551372C2777164284 @default.
• W2162551372 hasConceptScore W2162551372C2778024521 @default.
• W2162551372 hasConceptScore W2162551372C2778782382 @default.
• W2162551372 hasConceptScore W2162551372C2779029589 @default.

• next