FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162564035> ?p ?o ?g. }

• W2162564035 endingPage "25" @default.
• W2162564035 startingPage "4319" @default.
• W2162564035 abstract "The aim of this study was to evaluate the predictive utility of Insulin-like growth factor-1 receptor (IGF1R), IGF1, IGF2, Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and of hemoglobin levels for tumor response to exclusive radiotherapy, in patients with locally advanced Human papillomavirus (HPV) 16-positive cervical cancer.From 102 patients treated at our institutes, 38 patients with histologically-proven HPV16-positive cervical cancer were included in this prospective case-controlled study. All patients underwent exclusive radiotherapy-only. Complete response was defined as an absence of residual disease at clinical examination and radiological imaging, three months after the completion of treatment. Gene expression levels, assessed before radiotherapy, were compared between responders and non-responders. Controls consisted of normal cervical tissue samples from 30 patients with non-oncological indications.Twenty patients (52.6%) showed a complete response. Gene expressions of IGF1R (34%), IGF2 (24%), and GAPDH (median=3.26 versus 2.12) were increased in cancer patients, in comparison with the control group. Higher levels of expression of GAPDH were observed in patients co-expressing IGF2 and IGF1R, who had a hemoglobin level ≤ 11 g/dl (p=0.05). Clinical characteristics in the responder and in the non-responder groups were similar. In bi-variate and multi-variate analyses, IGF1R expression was the only factor predictive of response to radiotherapy (p=0.018). Accordingly, patients with IGF1R expression had a 28.6-fold greater risk of treatment failure.In our study, IGF1R was a strong predictive marker of lack of response to radiotherapy. Larger prospective trials are needed to validate IGF1R as a biomarker of radiation response for patients with HPV16-positive cervical cancer." @default.
• W2162564035 created "2016-06-24" @default.
• W2162564035 creator A5001628805 @default.
• W2162564035 creator A5013942703 @default.
• W2162564035 creator A5022853051 @default.
• W2162564035 creator A5032768666 @default.
• W2162564035 creator A5032972500 @default.
• W2162564035 creator A5036026276 @default.
• W2162564035 creator A5039689469 @default.
• W2162564035 creator A5057115225 @default.
• W2162564035 creator A5070297120 @default.
• W2162564035 creator A5073239916 @default.
• W2162564035 creator A5050254519 @default.
• W2162564035 date "2012-10-01" @default.
• W2162564035 modified "2023-10-06" @default.
• W2162564035 title "IGF1R gene expression as a predictive marker of response to ionizing radiation for patients with locally advanced HPV16-positive cervical cancer." @default.
• W2162564035 cites W1848388033 @default.
• W2162564035 cites W1970285990 @default.
• W2162564035 cites W1970633843 @default.
• W2162564035 cites W1976054107 @default.
• W2162564035 cites W1978393771 @default.
• W2162564035 cites W1997699669 @default.
• W2162564035 cites W2022797427 @default.
• W2162564035 cites W2040099337 @default.
• W2162564035 cites W2051839343 @default.
• W2162564035 cites W2060965633 @default.
• W2162564035 cites W2068484236 @default.
• W2162564035 cites W2078761044 @default.
• W2162564035 cites W2079690704 @default.
• W2162564035 cites W2093280226 @default.
• W2162564035 cites W2095769813 @default.
• W2162564035 cites W2101989193 @default.
• W2162564035 cites W2116150717 @default.
• W2162564035 cites W2134812217 @default.
• W2162564035 cites W2135165764 @default.
• W2162564035 cites W2138748709 @default.
• W2162564035 cites W2140575551 @default.
• W2162564035 cites W2141365513 @default.
• W2162564035 cites W2143146123 @default.
• W2162564035 cites W2146736665 @default.
• W2162564035 cites W2155142215 @default.
• W2162564035 cites W2165948908 @default.
• W2162564035 cites W2187704365 @default.
• W2162564035 cites W2187858368 @default.
• W2162564035 cites W2396591449 @default.
• W2162564035 cites W2435260598 @default.
• W2162564035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23060553" @default.
• W2162564035 hasPublicationYear "2012" @default.
• W2162564035 type Work @default.
• W2162564035 sameAs 2162564035 @default.
• W2162564035 citedByCount "12" @default.
• W2162564035 countsByYear W21625640352013 @default.
• W2162564035 countsByYear W21625640352015 @default.
• W2162564035 countsByYear W21625640352016 @default.
• W2162564035 countsByYear W21625640352017 @default.
• W2162564035 countsByYear W21625640352018 @default.
• W2162564035 countsByYear W21625640352019 @default.
• W2162564035 countsByYear W21625640352020 @default.
• W2162564035 countsByYear W21625640352022 @default.
• W2162564035 crossrefType "journal-article" @default.
• W2162564035 hasAuthorship W2162564035A5001628805 @default.
• W2162564035 hasAuthorship W2162564035A5013942703 @default.
• W2162564035 hasAuthorship W2162564035A5022853051 @default.
• W2162564035 hasAuthorship W2162564035A5032768666 @default.
• W2162564035 hasAuthorship W2162564035A5032972500 @default.
• W2162564035 hasAuthorship W2162564035A5036026276 @default.
• W2162564035 hasAuthorship W2162564035A5039689469 @default.
• W2162564035 hasAuthorship W2162564035A5050254519 @default.
• W2162564035 hasAuthorship W2162564035A5057115225 @default.
• W2162564035 hasAuthorship W2162564035A5070297120 @default.
• W2162564035 hasAuthorship W2162564035A5073239916 @default.
• W2162564035 hasConcept C121608353 @default.
• W2162564035 hasConcept C126322002 @default.
• W2162564035 hasConcept C142724271 @default.
• W2162564035 hasConcept C143998085 @default.
• W2162564035 hasConcept C144174609 @default.
• W2162564035 hasConcept C170493617 @default.
• W2162564035 hasConcept C188816634 @default.
• W2162564035 hasConcept C2775960820 @default.
• W2162564035 hasConcept C2778220009 @default.
• W2162564035 hasConcept C2780521871 @default.
• W2162564035 hasConcept C509974204 @default.
• W2162564035 hasConcept C71924100 @default.
• W2162564035 hasConcept C90924648 @default.
• W2162564035 hasConceptScore W2162564035C121608353 @default.
• W2162564035 hasConceptScore W2162564035C126322002 @default.
• W2162564035 hasConceptScore W2162564035C142724271 @default.
• W2162564035 hasConceptScore W2162564035C143998085 @default.
• W2162564035 hasConceptScore W2162564035C144174609 @default.
• W2162564035 hasConceptScore W2162564035C170493617 @default.
• W2162564035 hasConceptScore W2162564035C188816634 @default.
• W2162564035 hasConceptScore W2162564035C2775960820 @default.
• W2162564035 hasConceptScore W2162564035C2778220009 @default.
• W2162564035 hasConceptScore W2162564035C2780521871 @default.
• W2162564035 hasConceptScore W2162564035C509974204 @default.
• W2162564035 hasConceptScore W2162564035C71924100 @default.
• W2162564035 hasConceptScore W2162564035C90924648 @default.
• W2162564035 hasIssue "10" @default.

• next