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- W2162570341 abstract "Fifteen renal allografts and 5 autografts were placed into the necks of bilaterally nephrectomized sheep. Ten of the sheep with allografts were also treated with azathioprine (5 mg/kg) and prednisone (1.5 mg/kg) daily. There were no changes in the distribution of immunoglobulins or of βIC globulin which could be associated with the rapid decline in glomerular filtration rate observed in untreated allografts after 2 d and in ¡mmunosuppressed allografts after 6 d. However, this functional decline was associated with the development of interstitial oedema, lymphocyte infiltration, swelling of tubular and glomerular cells, and necrosis of the outer two-thirds of the renal cortex. Thus the onset of progressive cortical ischaemia appears to be an important event leading to renal allograft failure in sheep. Fifteen renal allografts and 5 autografts were placed into the necks of bilaterally nephrectomized sheep. Ten of the sheep with allografts were also treated with azathioprine (5 mg/kg) and prednisone (1.5 mg/kg) daily. There were no changes in the distribution of immunoglobulins or of βIC globulin which could be associated with the rapid decline in glomerular filtration rate observed in untreated allografts after 2 d and in ¡mmunosuppressed allografts after 6 d. However, this functional decline was associated with the development of interstitial oedema, lymphocyte infiltration, swelling of tubular and glomerular cells, and necrosis of the outer two-thirds of the renal cortex. Thus the onset of progressive cortical ischaemia appears to be an important event leading to renal allograft failure in sheep." @default.
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- W2162570341 date "1980-01-01" @default.
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- W2162570341 title "The pathogenesis of renal allograft rejection: An experimental investigation in sheep" @default.
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- W2162570341 doi "https://doi.org/10.3109/00313028009077097" @default.
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