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- W2162584080 abstract "Objective: The functional neurotrophic effects of systemic tacrolimus in a sub-immunosuppressiveregimen in the minipig model of laryngeal reinnervation were investigated.Methods: Right recurrent laryngeal nerve transection and phrenic-abductor branch of recurrent laryngeal nerve anastomosis were performed in two minipigs that were administered low-dose oral tacrolimus (0.125 mg/kg) for one month. Vocal cord abduction at four months was rated by two blindedexpert assessors on a four-point Likert scale from poor (1) to complete (4), and compared with fivefully matched historical control animals that received the same surgery but no other interventions.Results: Right vocal cord abduction was more complete in tacrolimus-treated animals than controls(mean abduction score 2.3 vs. 1.5, p=0.019).Conclusion: Tacrolimus may have an important role in laryngeal reinnervation following allograft transplantation, and low-dose regimens may have applications in cranial and peripheral nerve injuries or in the reinnervation of tissue-engineered laryngeal constructs, but further studies are required." @default.
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- W2162584080 date "2014-01-01" @default.
- W2162584080 modified "2023-09-24" @default.
- W2162584080 title "The Effect of Low-Dose Tacrolimus on Recurrent Laryngeal Nerve Regeneration in Pigs: A Pilot Study" @default.
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- W2162584080 doi "https://doi.org/10.5455/aces.20130427050406" @default.
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