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• W2162588804 abstract "Striated muscle represents one of the best models for studies on Ca2+ signalling. However, although much is known on the localisation and molecular interactions of the ryanodine receptors (RyRs), far less is known on the localisation and on the molecular interactions of the inositol trisphosphate receptors (InsP3Rs) in striated muscle cells. Recently, members of the Homer protein family have been shown to cluster type 1 metabotropic glutamate receptors (mGluR1) in the plasma membrane and to interact with InsP3R in the endoplasmic reticulum of neurons. Thus, these scaffolding proteins are good candidates for organising plasma membrane receptors and intracellular effector proteins in signalosomes involved in intracellular Ca2+ signalling. Homer proteins are also expressed in skeletal muscle, and the type 1 ryanodine receptor (RyR1) contains a specific Homer-binding motif. We report here on the relative sub-cellular localisation of InsP3Rs and Homer proteins in skeletal muscle cells with respect to the localisation of RyRs. Immunofluorescence analysis showed that both Homer and InsP3R proteins present a staining pattern indicative of a localisation at the Z-line, clearly distinct from that of RyR1. Consistent herewith, in sub-cellular fractionation experiments, Homer proteins and InsP3R were both found in the fractions enriched in longitudinal sarcoplasmic reticulum (LSR) but not in fractions of terminal cisternae that are enriched in RyRs. Thus, in skeletal muscle, Homer proteins may play a role in the organisation of a second Ca2+ signalling compartment containing the InsP3R, but are apparently not involved in the organisation of RyRs at triads." @default.
• W2162588804 created "2016-06-24" @default.
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• W2162588804 date "2002-10-01" @default.
• W2162588804 modified "2023-10-07" @default.
• W2162588804 title "Homer proteins and InsP3 receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibres" @default.
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• W2162588804 doi "https://doi.org/10.1016/s0143416002001549" @default.
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