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• W2162594518 endingPage "L105" @default.
• W2162594518 startingPage "L97" @default.
• W2162594518 abstract "Surfactant protein (SP) D is a pulmonary surfactant-associated protein that may function in lung host defense. SP-D is produced by alveolar type II cells and nonciliated bronchiolar epithelial (Clara) cells of the airway and is secreted into the air space. Here we investigated whether alveolar macrophages degraded SP-D in vitro. We also examined the effects of SP-A and lipids on SP-D metabolism. The results showed that alveolar macrophages bound and degraded SP-D in a time- and temperature-dependent fashion. After 100 min of incubation, the formation of trichloroacetic acid-soluble degradation products increased 4-fold in the medium and 30-fold in the cells. The degradation of SP-D was via a cell-associated process because SP-D was not degraded when incubated in medium previously conditioned by alveolar macrophages. Gel autoradiography of cell lysate samples after incubation with 125 I-labeled SP-D demonstrated an increase in degradation products, further confirming the degradation of SP-D by alveolar macrophages. In addition, the degradation of SP-D was not affected by coincubation with SP-A or surfactant-like liposomes containing either phosphatidylglycerol or phosphatidylinositol. In conclusion, alveolar macrophages rapidly degrade SP-D and may play an important role in SP-D turnover and clearance." @default.
• W2162594518 created "2016-06-24" @default.
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• W2162594518 creator A5058518142 @default.
• W2162594518 date "1998-01-01" @default.
• W2162594518 modified "2023-09-27" @default.
• W2162594518 title "Degradation of surfactant protein D by alveolar macrophages" @default.
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• W2162594518 doi "https://doi.org/10.1152/ajplung.1998.274.1.l97" @default.
• W2162594518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9458806" @default.
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