FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162602240> ?p ?o ?g. }

• W2162602240 endingPage "209" @default.
• W2162602240 startingPage "209" @default.
• W2162602240 abstract "PURPOSE: amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective properties. riluzole and minocycline were given to an animal model of ALS and had beneficial effect on the disease. The combination was then tested in humans in phase II and phase III studies with less beneficial effects and a faster decline of the disease in the group treated with minocycline. In a previous study, we showed that riluzole is transported out of the brain by the P-glycoprotein at the blood-brain barrier level. METHODS: in this work, we studied in CF1 mice, the plasmatic and cerebral pharmacokinetics of riluzole combined or not with minocycline. RESULTS: our results showed that the kinetics of riluzole are not linear with dose, but that cerebral AUC0-∞ increase proportionally with plasmatic AUC0-∞. At the dose of 10 mg/kg, the cerebral AUC0-∞ /plasmatic AUC0-∞ ratio was 4.6 in mdr1a (-/-) mice and 2.4 in mdr1a (+/+) mice. The combination of minocycline (170 mg/kg) and riluzole (10 mg/kg) induced a 2 fold increase in the cerebral AUC0-∞ of riluzole and induced a neuromuscular toxicity in mice. This effect of minocycline was not found at low concentration (10 mg/kg of minocycline). CONCLUSIONS: if our results are confirmed in humans, riluzole cerebral concentrations could be predicted by plasmatic concentrations. Furthermore, the combination of high doses of minocycline with riluzole could induce neurological toxicity that lead to deceiving results in ALS clinical studies." @default.
• W2162602240 created "2016-06-24" @default.
• W2162602240 creator A5019319877 @default.
• W2162602240 creator A5029754351 @default.
• W2162602240 creator A5049637018 @default.
• W2162602240 creator A5057953137 @default.
• W2162602240 creator A5069426053 @default.
• W2162602240 creator A5071030872 @default.
• W2162602240 date "2009-08-10" @default.
• W2162602240 modified "2023-10-16" @default.
• W2162602240 title "Brain and Plasma Riluzole Pharmacokinetics: Effect of Minocycline Combination" @default.
• W2162602240 cites W1485896673 @default.
• W2162602240 cites W1980067683 @default.
• W2162602240 cites W2001097099 @default.
• W2162602240 cites W2011927655 @default.
• W2162602240 cites W2021374516 @default.
• W2162602240 cites W2039184260 @default.
• W2162602240 cites W2040088974 @default.
• W2162602240 cites W2047695690 @default.
• W2162602240 cites W2073864172 @default.
• W2162602240 cites W2074455856 @default.
• W2162602240 cites W2081232907 @default.
• W2162602240 cites W2081374761 @default.
• W2162602240 cites W2085165928 @default.
• W2162602240 cites W2087315895 @default.
• W2162602240 cites W2092108048 @default.
• W2162602240 cites W2120681040 @default.
• W2162602240 cites W2144536780 @default.
• W2162602240 cites W2170125790 @default.
• W2162602240 cites W2314689571 @default.
• W2162602240 cites W2332156741 @default.
• W2162602240 cites W2408150743 @default.
• W2162602240 doi "https://doi.org/10.18433/j36c78" @default.
• W2162602240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19732498" @default.
• W2162602240 hasPublicationYear "2009" @default.
• W2162602240 type Work @default.
• W2162602240 sameAs 2162602240 @default.
• W2162602240 citedByCount "34" @default.
• W2162602240 countsByYear W21626022402012 @default.
• W2162602240 countsByYear W21626022402013 @default.
• W2162602240 countsByYear W21626022402014 @default.
• W2162602240 countsByYear W21626022402016 @default.
• W2162602240 countsByYear W21626022402017 @default.
• W2162602240 countsByYear W21626022402018 @default.
• W2162602240 countsByYear W21626022402020 @default.
• W2162602240 countsByYear W21626022402021 @default.
• W2162602240 countsByYear W21626022402022 @default.
• W2162602240 countsByYear W21626022402023 @default.
• W2162602240 crossrefType "journal-article" @default.
• W2162602240 hasAuthorship W2162602240A5019319877 @default.
• W2162602240 hasAuthorship W2162602240A5029754351 @default.
• W2162602240 hasAuthorship W2162602240A5049637018 @default.
• W2162602240 hasAuthorship W2162602240A5057953137 @default.
• W2162602240 hasAuthorship W2162602240A5069426053 @default.
• W2162602240 hasAuthorship W2162602240A5071030872 @default.
• W2162602240 hasBestOaLocation W21626022401 @default.
• W2162602240 hasConcept C112705442 @default.
• W2162602240 hasConcept C126322002 @default.
• W2162602240 hasConcept C185592680 @default.
• W2162602240 hasConcept C25498285 @default.
• W2162602240 hasConcept C2778275353 @default.
• W2162602240 hasConcept C2779134260 @default.
• W2162602240 hasConcept C2779319286 @default.
• W2162602240 hasConcept C2780596555 @default.
• W2162602240 hasConcept C29730261 @default.
• W2162602240 hasConcept C42219234 @default.
• W2162602240 hasConcept C501593827 @default.
• W2162602240 hasConcept C55493867 @default.
• W2162602240 hasConcept C71924100 @default.
• W2162602240 hasConcept C98274493 @default.
• W2162602240 hasConceptScore W2162602240C112705442 @default.
• W2162602240 hasConceptScore W2162602240C126322002 @default.
• W2162602240 hasConceptScore W2162602240C185592680 @default.
• W2162602240 hasConceptScore W2162602240C25498285 @default.
• W2162602240 hasConceptScore W2162602240C2778275353 @default.
• W2162602240 hasConceptScore W2162602240C2779134260 @default.
• W2162602240 hasConceptScore W2162602240C2779319286 @default.
• W2162602240 hasConceptScore W2162602240C2780596555 @default.
• W2162602240 hasConceptScore W2162602240C29730261 @default.
• W2162602240 hasConceptScore W2162602240C42219234 @default.
• W2162602240 hasConceptScore W2162602240C501593827 @default.
• W2162602240 hasConceptScore W2162602240C55493867 @default.
• W2162602240 hasConceptScore W2162602240C71924100 @default.
• W2162602240 hasConceptScore W2162602240C98274493 @default.
• W2162602240 hasIssue "2" @default.
• W2162602240 hasLocation W21626022401 @default.
• W2162602240 hasLocation W21626022402 @default.
• W2162602240 hasLocation W21626022403 @default.
• W2162602240 hasOpenAccess W2162602240 @default.
• W2162602240 hasPrimaryLocation W21626022401 @default.
• W2162602240 hasRelatedWork W2076153179 @default.
• W2162602240 hasRelatedWork W2113542630 @default.
• W2162602240 hasRelatedWork W2166455544 @default.
• W2162602240 hasRelatedWork W2314689571 @default.
• W2162602240 hasRelatedWork W2340610284 @default.
• W2162602240 hasRelatedWork W2772668409 @default.
• W2162602240 hasRelatedWork W4205595123 @default.
• W2162602240 hasRelatedWork W4213128270 @default.

• next